Novel Benzimidazo[2,1-c][1,4]thiazinone Derivatives with Potent Activity Against HSV-1

The synthesis of new 2‐carboxymethylsulfanylmethyl‐1H‐benzimidazole and 1,3‐dihydro‐4H‐benzo[4′,5′]imidazo[2,1‐c][1,4]thiazine‐4‐one‐8‐carboxylic acid derivatives was investigated. The antiviral activity of compounds 1–14 was tested against the herpes simplex virus 1. Compounds 5 and 14 showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50 µg, respectively. Compounds 5 and 14 showed higher potency than Acyclovir at doses of 20 µg and 50 µg. Novel benzimidazo[2,1‐c][1,4]thiazinone derivatives were synthesized and tested against the herpes simplex virus 1. Two compounds showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50µg, respectively.