Phosphoinositide 3 kinase mediates toll-like receptor 4-induced activation of NF-KB in endothelial cells

Many of the proinflammatory effects of gram-negative bacteria are elicited by the interaction of bacterial lipopolysaccharide (LPS) with Toll-like receptor 4 (TLR4) expressed on host cells. TLR4 signaling leads to activation of NF-kB and transcription of many genes involved in the inflammatory respo...

Ausführliche Beschreibung