Epigallocatechin‐3‐gallate protects kidneys from ischemia reperfusion injury by HO‐1 upregulation and inhibition of macrophage infiltration

Summary Epigallocatechin‐3‐gallate (EGCG) shows diverse chemical and biological activities. We investigated the effects of EGCG in a rat renal ischemia reperfusion (I/R) injury model. Sprague–Dawley rats received intraperitoneal injection of 50 mg/kg EGCG 48 h, 24 h, and 30 min prior to I/R injury....

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Veröffentlicht in:	Transplant international 2011-05, Vol.24 (5), p.514-522
Hauptverfasser:	Kakuta, Yoichi, Okumi, Masayoshi, Isaka, Yoshitaka, Tsutahara, Koichi, Abe, Toyofumi, Yazawa, Koji, Ichimaru, Naotsugu, Matsumura, Kazuaki, Hyon, Suong‐Hyu, Takahara, Shiro, Nonomura, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Apoptosis Catechin - analogs & derivatives Catechin - pharmacology EGCG Heme Oxygenase (Decyclizing) - metabolism Ischemia ischemia reperfusion injury kidney Kidney - drug effects Kidney - embryology Lipid Peroxidation macrophage Macrophages - metabolism Malondialdehyde - metabolism Muscle, Smooth - metabolism Organic Chemicals - pharmacology Rats Rats, Sprague-Dawley Reperfusion Injury - prevention & control Reverse Transcriptase Polymerase Chain Reaction Rodents Up-Regulation
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