EEG‐fMRI reveals activation of brainstem and thalamus in patients with Lennox‐Gastaut syndrome
Summary Purpose: Even if etiologies of Lennox‐Gastaut syndrome (LGS) are diverse, the multiple causes converge into a final common pathway that results in this specific epilepsy phenotype. There is little knowledge, however, about neuronal networks that may be a part of this pathway. Methods: To i...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2011-04, Vol.52 (4), p.766-774 |
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| container_title | Epilepsia (Copenhagen) |
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| creator | Siniatchkin, Michael Coropceanu, Diana Moeller, Friederike Boor, Rainer Stephani, Ulrich |
| description | Summary
Purpose: Even if etiologies of Lennox‐Gastaut syndrome (LGS) are diverse, the multiple causes converge into a final common pathway that results in this specific epilepsy phenotype. There is little knowledge, however, about neuronal networks that may be a part of this pathway.
Methods: To investigate these networks, 11 children with LGS and 9 control children with multifocal epileptic activity were investigated using simultaneous recordings of EEG and functional MRI (EEG‐fMRI) in a 3 Tesla scanner.
Key Findings: Individual and group analyses revealed significant activation of brainstem and thalamus (especially centromedian and anterior thalamus) associated with epileptiform discharges in patients with LGS. None of the patients with multifocal epileptic activity presented with the same hemodynamic activation pattern.
Significance: Because brainstem activation has been associated with infantile spasms, which often evolve into LGS, and thalamus activation has been observed in patients with primary (idiopathic generalized syndromes) and secondary (focal epilepsies) bilateral synchrony, the described network in LGS may represent the common pathogenetic pathway of these different conditions. |
| doi_str_mv | 10.1111/j.1528-1167.2010.02948.x |
| format | Article |
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Purpose: Even if etiologies of Lennox‐Gastaut syndrome (LGS) are diverse, the multiple causes converge into a final common pathway that results in this specific epilepsy phenotype. There is little knowledge, however, about neuronal networks that may be a part of this pathway.
Methods: To investigate these networks, 11 children with LGS and 9 control children with multifocal epileptic activity were investigated using simultaneous recordings of EEG and functional MRI (EEG‐fMRI) in a 3 Tesla scanner.
Key Findings: Individual and group analyses revealed significant activation of brainstem and thalamus (especially centromedian and anterior thalamus) associated with epileptiform discharges in patients with LGS. None of the patients with multifocal epileptic activity presented with the same hemodynamic activation pattern.
Significance: Because brainstem activation has been associated with infantile spasms, which often evolve into LGS, and thalamus activation has been observed in patients with primary (idiopathic generalized syndromes) and secondary (focal epilepsies) bilateral synchrony, the described network in LGS may represent the common pathogenetic pathway of these different conditions.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2010.02948.x</identifier><identifier>PMID: 21275978</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Brain ; Brain Stem - blood supply ; Brain Stem - physiopathology ; Brainstem ; Child ; Child, Preschool ; Children ; Complex syndromes ; EEG‐fMRI ; Electroencephalography - methods ; Epilepsy ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Intellectual Disability - diagnosis ; Intellectual Disability - physiopathology ; Lennox Gastaut Syndrome ; Magnetic Resonance Imaging - methods ; Male ; Medical genetics ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Spasms, Infantile - diagnosis ; Spasms, Infantile - physiopathology ; Thalamus ; Thalamus - blood supply ; Thalamus - physiopathology</subject><ispartof>Epilepsia (Copenhagen), 2011-04, Vol.52 (4), p.766-774</ispartof><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy</rights><rights>2015 INIST-CNRS</rights><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4268-c535f5898e0714ac2c8a374893eae8bc0fde3c071c26a0e8885f04ccdbe13e533</citedby><cites>FETCH-LOGICAL-c4268-c535f5898e0714ac2c8a374893eae8bc0fde3c071c26a0e8885f04ccdbe13e533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2010.02948.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2010.02948.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24104017$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21275978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siniatchkin, Michael</creatorcontrib><creatorcontrib>Coropceanu, Diana</creatorcontrib><creatorcontrib>Moeller, Friederike</creatorcontrib><creatorcontrib>Boor, Rainer</creatorcontrib><creatorcontrib>Stephani, Ulrich</creatorcontrib><title>EEG‐fMRI reveals activation of brainstem and thalamus in patients with Lennox‐Gastaut syndrome</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Purpose: Even if etiologies of Lennox‐Gastaut syndrome (LGS) are diverse, the multiple causes converge into a final common pathway that results in this specific epilepsy phenotype. There is little knowledge, however, about neuronal networks that may be a part of this pathway.
Methods: To investigate these networks, 11 children with LGS and 9 control children with multifocal epileptic activity were investigated using simultaneous recordings of EEG and functional MRI (EEG‐fMRI) in a 3 Tesla scanner.
Key Findings: Individual and group analyses revealed significant activation of brainstem and thalamus (especially centromedian and anterior thalamus) associated with epileptiform discharges in patients with LGS. None of the patients with multifocal epileptic activity presented with the same hemodynamic activation pattern.
Significance: Because brainstem activation has been associated with infantile spasms, which often evolve into LGS, and thalamus activation has been observed in patients with primary (idiopathic generalized syndromes) and secondary (focal epilepsies) bilateral synchrony, the described network in LGS may represent the common pathogenetic pathway of these different conditions.</description><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Stem - blood supply</subject><subject>Brain Stem - physiopathology</subject><subject>Brainstem</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complex syndromes</subject><subject>EEG‐fMRI</subject><subject>Electroencephalography - methods</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Intellectual Disability - diagnosis</subject><subject>Intellectual Disability - physiopathology</subject><subject>Lennox Gastaut Syndrome</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Spasms, Infantile - diagnosis</subject><subject>Spasms, Infantile - physiopathology</subject><subject>Thalamus</subject><subject>Thalamus - blood supply</subject><subject>Thalamus - physiopathology</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhS0EYsrAKyBLCM0qxT9x7CxYoFEplYpACNaW49xoXCVOsZ2Zdscj8Iw8Cc60DBIrvLHl-91zr85BCFOypPm82S2pYKqgtJJLRvIvYXWplodHaPFQeIwWhFBe1EKRC_Qsxh0hRFaSP0UXjDIpaqkWqFmt1r9-_Ow-ftngALdg-oiNTe7WJDd6PHa4Ccb5mGDAxrc43ZjeDFPEzuN9ZsCniO9cusFb8H48ZK21iclMCcejb8M4wHP0pMuy8OJ8X6Jv71dfrz8U20_rzfW7bWFLVqnCCi46oWoFRNLSWGaV4bJUNQcDqrGka4HbXLOsMgSUUqIjpbVtA5SD4PwSXZ1092H8PkFMenDRQt8bD-MUtaoIryWVVSZf_UPuxin4vJymgkrGZX2vp06UDWOMATq9D24w4agp0XMMeqdnt_Xstp5j0Pcx6ENufXkeMDUDtA-Nf3zPwOszYKI1fReMty7-5UpKSkJl5t6euDvXw_G_F9Crz5v5xX8DPvKkzQ</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Siniatchkin, Michael</creator><creator>Coropceanu, Diana</creator><creator>Moeller, Friederike</creator><creator>Boor, Rainer</creator><creator>Stephani, Ulrich</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>EEG‐fMRI reveals activation of brainstem and thalamus in patients with Lennox‐Gastaut syndrome</title><author>Siniatchkin, Michael ; Coropceanu, Diana ; Moeller, Friederike ; Boor, Rainer ; Stephani, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4268-c535f5898e0714ac2c8a374893eae8bc0fde3c071c26a0e8885f04ccdbe13e533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Stem - blood supply</topic><topic>Brain Stem - physiopathology</topic><topic>Brainstem</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Complex syndromes</topic><topic>EEG‐fMRI</topic><topic>Electroencephalography - methods</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Intellectual Disability - diagnosis</topic><topic>Intellectual Disability - physiopathology</topic><topic>Lennox Gastaut Syndrome</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Spasms, Infantile - diagnosis</topic><topic>Spasms, Infantile - physiopathology</topic><topic>Thalamus</topic><topic>Thalamus - blood supply</topic><topic>Thalamus - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siniatchkin, Michael</creatorcontrib><creatorcontrib>Coropceanu, Diana</creatorcontrib><creatorcontrib>Moeller, Friederike</creatorcontrib><creatorcontrib>Boor, Rainer</creatorcontrib><creatorcontrib>Stephani, Ulrich</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siniatchkin, Michael</au><au>Coropceanu, Diana</au><au>Moeller, Friederike</au><au>Boor, Rainer</au><au>Stephani, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EEG‐fMRI reveals activation of brainstem and thalamus in patients with Lennox‐Gastaut syndrome</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2011-04</date><risdate>2011</risdate><volume>52</volume><issue>4</issue><spage>766</spage><epage>774</epage><pages>766-774</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Purpose: Even if etiologies of Lennox‐Gastaut syndrome (LGS) are diverse, the multiple causes converge into a final common pathway that results in this specific epilepsy phenotype. There is little knowledge, however, about neuronal networks that may be a part of this pathway.
Methods: To investigate these networks, 11 children with LGS and 9 control children with multifocal epileptic activity were investigated using simultaneous recordings of EEG and functional MRI (EEG‐fMRI) in a 3 Tesla scanner.
Key Findings: Individual and group analyses revealed significant activation of brainstem and thalamus (especially centromedian and anterior thalamus) associated with epileptiform discharges in patients with LGS. None of the patients with multifocal epileptic activity presented with the same hemodynamic activation pattern.
Significance: Because brainstem activation has been associated with infantile spasms, which often evolve into LGS, and thalamus activation has been observed in patients with primary (idiopathic generalized syndromes) and secondary (focal epilepsies) bilateral synchrony, the described network in LGS may represent the common pathogenetic pathway of these different conditions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21275978</pmid><doi>10.1111/j.1528-1167.2010.02948.x</doi><tpages>9</tpages></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE; Wiley Free Archive; IngentaConnect Open Access; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Biological and medical sciences Brain Brain Stem - blood supply Brain Stem - physiopathology Brainstem Child Child, Preschool Children Complex syndromes EEG‐fMRI Electroencephalography - methods Epilepsy Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Intellectual Disability - diagnosis Intellectual Disability - physiopathology Lennox Gastaut Syndrome Magnetic Resonance Imaging - methods Male Medical genetics Medical sciences Nervous system (semeiology, syndromes) Neurology Spasms, Infantile - diagnosis Spasms, Infantile - physiopathology Thalamus Thalamus - blood supply Thalamus - physiopathology |
| title | EEG‐fMRI reveals activation of brainstem and thalamus in patients with Lennox‐Gastaut syndrome |
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