Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism
The present study investigated whether the antioxidant activity of p,p'‐methoxyl‐diphenyl diselenide [(MeOPhSe)2] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were tr...
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| Veröffentlicht in: | Cell biochemistry and function 2011-04, Vol.29 (3), p.235-243 |
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| creator | Pinton, Simone da Rocha, Juliana Trevisan Gai, Bibiana Mozzaquatro Prigol, Marina da Rosa, Luiz Vinícius Nogueira, Cristina Wayne |
| description | The present study investigated whether the antioxidant activity of p,p'‐methoxyl‐diphenyl diselenide [(MeOPhSe)2] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml−1 solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)2 (25 mg kg−1) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)2 on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y‐maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)2 protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)2 protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S‐transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)2 on SDAT induced by STZ in mice. Copyright © 2011 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/cbf.1741 |
| format | Article |
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Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml−1 solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)2 (25 mg kg−1) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)2 on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y‐maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)2 protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)2 protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S‐transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)2 on SDAT induced by STZ in mice. Copyright © 2011 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0263-6484</identifier><identifier>ISSN: 1099-0844</identifier><identifier>EISSN: 1099-0844</identifier><identifier>DOI: 10.1002/cbf.1741</identifier><identifier>PMID: 21465495</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Alzheimer Disease - chemically induced ; Alzheimer Disease - metabolism ; Alzheimer Disease - psychology ; Animals ; antioxidant ; Antioxidants - chemical synthesis ; Antioxidants - pharmacology ; Avoidance Learning - drug effects ; Benzene Derivatives - chemical synthesis ; Benzene Derivatives - pharmacology ; Brain - drug effects ; Brain - metabolism ; Catalase - metabolism ; Dementia - chemically induced ; Dementia - metabolism ; Dementia - psychology ; dementia of Alzheimer's type ; Disease Models, Animal ; Glutathione - metabolism ; Glutathione Transferase - metabolism ; Infusions, Intraventricular ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Memory - drug effects ; Memory - physiology ; Mice ; Neuroprotective Agents - pharmacology ; Organoselenium Compounds - chemical synthesis ; Organoselenium Compounds - pharmacology ; oxidative stress ; Oxidative Stress - drug effects ; Reactive Oxygen Species - metabolism ; selenium ; Streptozocin - administration & dosage ; Streptozocin - adverse effects ; streptozotocin ; Superoxide Dismutase - metabolism</subject><ispartof>Cell biochemistry and function, 2011-04, Vol.29 (3), p.235-243</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4241-7bccdca2e5809c194d495c1c6c3d3e21015e94ce16703f1f3f382dfa48e4643a3</citedby><cites>FETCH-LOGICAL-c4241-7bccdca2e5809c194d495c1c6c3d3e21015e94ce16703f1f3f382dfa48e4643a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbf.1741$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbf.1741$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21465495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinton, Simone</creatorcontrib><creatorcontrib>da Rocha, Juliana Trevisan</creatorcontrib><creatorcontrib>Gai, Bibiana Mozzaquatro</creatorcontrib><creatorcontrib>Prigol, Marina</creatorcontrib><creatorcontrib>da Rosa, Luiz Vinícius</creatorcontrib><creatorcontrib>Nogueira, Cristina Wayne</creatorcontrib><title>Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism</title><title>Cell biochemistry and function</title><addtitle>Cell Biochem. Funct</addtitle><description>The present study investigated whether the antioxidant activity of p,p'‐methoxyl‐diphenyl diselenide [(MeOPhSe)2] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml−1 solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)2 (25 mg kg−1) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)2 on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y‐maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)2 protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)2 protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S‐transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)2 on SDAT induced by STZ in mice. Copyright © 2011 John Wiley & Sons, Ltd.</description><subject>Alzheimer Disease - chemically induced</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - psychology</subject><subject>Animals</subject><subject>antioxidant</subject><subject>Antioxidants - chemical synthesis</subject><subject>Antioxidants - pharmacology</subject><subject>Avoidance Learning - drug effects</subject><subject>Benzene Derivatives - chemical synthesis</subject><subject>Benzene Derivatives - pharmacology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Catalase - metabolism</subject><subject>Dementia - chemically induced</subject><subject>Dementia - metabolism</subject><subject>Dementia - psychology</subject><subject>dementia of Alzheimer's type</subject><subject>Disease Models, Animal</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>Infusions, Intraventricular</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Mice</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Organoselenium Compounds - chemical synthesis</subject><subject>Organoselenium Compounds - pharmacology</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>selenium</subject><subject>Streptozocin - administration & dosage</subject><subject>Streptozocin - adverse effects</subject><subject>streptozotocin</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0263-6484</issn><issn>1099-0844</issn><issn>1099-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1u1DAUBeAIgehQkHgC5N2waIr_4tjsyqhTkErZFLG0PPaNxhDHwU7EhHfhXUnoUFbA6lrWd49kn6J4TvA5wZi-srvmnNScPChWBCtVYsn5w2KFqWCl4JKfFE9y_owxVoLhx8UJJVxUXFWr4scNjCn2KQ5gh5gQNM18QLFB_Vm_LgMM-3iY2tL5fg_d1CLnM7TQeQfId8igEB20i899TMZ5ixwE6AZvlsuL9vsefIC0zmiY-l87wVt4jWzshuR34-Bjt0gzr8SDd_NEAezedD6Hp8WjxrQZnh3nafFxe3m7eVtef7h6t7m4Li2nnJT1zlpnDYVKYmWJ4m5-myVWWOYYUIJJBYpbIKLGrCENa5ikrjFcAhecGXZarO9y54_4OkIedPDZQtuaDuKYtRSYKaEInuXLf0pSV5IyxSv-f8pEzSWlUvyhNsWcEzS6Tz6YNGmC9dKwnhvWS8MzfXFMHXcB3D38XekMyjvwzbcw_TVIb95sj4FH7_MAh3tv0hctalZX-tPNlb4l21rS90xv2U89tb_l</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Pinton, Simone</creator><creator>da Rocha, Juliana Trevisan</creator><creator>Gai, Bibiana Mozzaquatro</creator><creator>Prigol, Marina</creator><creator>da Rosa, Luiz Vinícius</creator><creator>Nogueira, Cristina Wayne</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism</title><author>Pinton, Simone ; da Rocha, Juliana Trevisan ; Gai, Bibiana Mozzaquatro ; Prigol, Marina ; da Rosa, Luiz Vinícius ; Nogueira, Cristina Wayne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4241-7bccdca2e5809c194d495c1c6c3d3e21015e94ce16703f1f3f382dfa48e4643a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alzheimer Disease - chemically induced</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - psychology</topic><topic>Animals</topic><topic>antioxidant</topic><topic>Antioxidants - chemical synthesis</topic><topic>Antioxidants - pharmacology</topic><topic>Avoidance Learning - drug effects</topic><topic>Benzene Derivatives - chemical synthesis</topic><topic>Benzene Derivatives - pharmacology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Catalase - metabolism</topic><topic>Dementia - chemically induced</topic><topic>Dementia - metabolism</topic><topic>Dementia - psychology</topic><topic>dementia of Alzheimer's type</topic><topic>Disease Models, Animal</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>Infusions, Intraventricular</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Maze Learning - physiology</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Mice</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Organoselenium Compounds - chemical synthesis</topic><topic>Organoselenium Compounds - pharmacology</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>selenium</topic><topic>Streptozocin - administration & dosage</topic><topic>Streptozocin - adverse effects</topic><topic>streptozotocin</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinton, Simone</creatorcontrib><creatorcontrib>da Rocha, Juliana Trevisan</creatorcontrib><creatorcontrib>Gai, Bibiana Mozzaquatro</creatorcontrib><creatorcontrib>Prigol, Marina</creatorcontrib><creatorcontrib>da Rosa, Luiz Vinícius</creatorcontrib><creatorcontrib>Nogueira, Cristina Wayne</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biochemistry and function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinton, Simone</au><au>da Rocha, Juliana Trevisan</au><au>Gai, Bibiana Mozzaquatro</au><au>Prigol, Marina</au><au>da Rosa, Luiz Vinícius</au><au>Nogueira, Cristina Wayne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism</atitle><jtitle>Cell biochemistry and function</jtitle><addtitle>Cell Biochem. Funct</addtitle><date>2011-04</date><risdate>2011</risdate><volume>29</volume><issue>3</issue><spage>235</spage><epage>243</epage><pages>235-243</pages><issn>0263-6484</issn><issn>1099-0844</issn><eissn>1099-0844</eissn><abstract>The present study investigated whether the antioxidant activity of p,p'‐methoxyl‐diphenyl diselenide [(MeOPhSe)2] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml−1 solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)2 (25 mg kg−1) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)2 on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y‐maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)2 protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)2 protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S‐transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)2 on SDAT induced by STZ in mice. Copyright © 2011 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21465495</pmid><doi>10.1002/cbf.1741</doi><tpages>9</tpages></addata></record> |
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| subjects | Alzheimer Disease - chemically induced Alzheimer Disease - metabolism Alzheimer Disease - psychology Animals antioxidant Antioxidants - chemical synthesis Antioxidants - pharmacology Avoidance Learning - drug effects Benzene Derivatives - chemical synthesis Benzene Derivatives - pharmacology Brain - drug effects Brain - metabolism Catalase - metabolism Dementia - chemically induced Dementia - metabolism Dementia - psychology dementia of Alzheimer's type Disease Models, Animal Glutathione - metabolism Glutathione Transferase - metabolism Infusions, Intraventricular Male Maze Learning - drug effects Maze Learning - physiology Memory - drug effects Memory - physiology Mice Neuroprotective Agents - pharmacology Organoselenium Compounds - chemical synthesis Organoselenium Compounds - pharmacology oxidative stress Oxidative Stress - drug effects Reactive Oxygen Species - metabolism selenium Streptozocin - administration & dosage Streptozocin - adverse effects streptozotocin Superoxide Dismutase - metabolism |
| title | Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism |
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