Kindling alters neurosteroid-induced modulation of phasic and tonic GABAA receptor-mediated currents: role of phosphorylation

J. Neurochem. (2011) 116, 1043-1056. ABSTRACT: We have previously shown that after kindling (a model of temporal lobe epilepsy), the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) was unable to augment GABA type A receptor (GABAA)-mediated synaptic currents occurring on pyramidal cells of...

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Veröffentlicht in:	Journal of neurochemistry 2011-03, Vol.116 (6), p.1043-1056
Hauptverfasser:	Kia, Arash, Ribeiro, Fabiola, Nelson, Renee, Gavrilovici, Cezar, Ferguson, Stephen S.G, Poulter, Michael O
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacid receptors (glycine, glutamate, gaba) Animals Biological and medical sciences bisindolylmaleimide I Brain Brain slice preparation Cell receptors Cell structures and functions Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cortex (piriform) Cortex (temporal) Data processing Desoxycorticosterone - analogs & derivatives Desoxycorticosterone - pharmacology Enzyme Inhibitors - pharmacology Epilepsy Fundamental and applied biological sciences. Psychology GABAA receptor gamma -Aminobutyric acid A receptors Gene Expression Regulation - drug effects Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy In Vitro Techniques Indoles - pharmacology Inhibitory Postsynaptic Potentials - drug effects Kindling Kindling, Neurologic - pathology Male Maleimides - pharmacology Medical sciences Molecular and cellular biology Nervous system (semeiology, syndromes) Neurochemistry Neurology Neuromodulation Neurons Neurosteroids Neurotransmitter Agents - pharmacology Patch-Clamp Techniques - methods phorbol 12-myristate 13-acetate Phorbol esters Phorbol Esters - pharmacology Phosphorylation Phosphorylation - drug effects Phosphorylation - physiology Protein kinase C Pyramidal cells Pyramidal Cells - drug effects Rats Rats, Sprague-Dawley Receptors, GABA - genetics Receptors, GABA - metabolism Staurosporine Steroids Temporal lobe
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