Brachyury expression predicts poor prognosis at early stages of colorectal cancer
Abstract Although survival rates of colon cancer patients diagnosed at an early stage (T1-2N0M0; Dukes A) vary considerably according to the studies cited, several studies indicate development of distant metastases already occurring in a considerable percentage of these patients leading to the death...
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| Veröffentlicht in: | European journal of cancer (1990) 2011-05, Vol.47 (7), p.1080-1085 |
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| container_title | European journal of cancer (1990) |
| container_volume | 47 |
| creator | Kilic, Nerbil Feldhaus, Susanne Kilic, Ergin Tennstedt, Pierre Wicklein, Daniel Wasielewski, Reinhard von Viebahn, Christoph Kreipe, Hans Schumacher, Udo |
| description | Abstract Although survival rates of colon cancer patients diagnosed at an early stage (T1-2N0M0; Dukes A) vary considerably according to the studies cited, several studies indicate development of distant metastases already occurring in a considerable percentage of these patients leading to the death of the patients. This particular high risk group cannot be identified properly as no marker exists to identify these patients. As the Wnt/Win pathway plays a crucial role in metastasis formation in colorectal carcinoma, we analysed whether the transcription factor brachyury critically involved in this pathway may predict metastasis formation in these patients. The expression of brachyury-homologous (T) was immunohistochemically analysed in 748 patients and the data were correlated with classical and newer prognostic markers in colorectal cancer. Early stages colorectal cancer patients (T1-2N0M0, Dukes A) showed a significantly decreased survival when brachyury was expressed in the tumour tissue while no correlation was observed in later tumour stages. Hence a subset of colorectal cancers exists in which the ability to metastasise is already present at early stages of tumour growth and this high risk group can now be detected by immunohistochemistry. |
| doi_str_mv | 10.1016/j.ejca.2010.11.015 |
| format | Article |
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This particular high risk group cannot be identified properly as no marker exists to identify these patients. As the Wnt/Win pathway plays a crucial role in metastasis formation in colorectal carcinoma, we analysed whether the transcription factor brachyury critically involved in this pathway may predict metastasis formation in these patients. The expression of brachyury-homologous (T) was immunohistochemically analysed in 748 patients and the data were correlated with classical and newer prognostic markers in colorectal cancer. Early stages colorectal cancer patients (T1-2N0M0, Dukes A) showed a significantly decreased survival when brachyury was expressed in the tumour tissue while no correlation was observed in later tumour stages. Hence a subset of colorectal cancers exists in which the ability to metastasise is already present at early stages of tumour growth and this high risk group can now be detected by immunohistochemistry.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2010.11.015</identifier><identifier>PMID: 21220197</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Brachyury transcription factor ; Cell Separation ; Colorectal adenocarcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - genetics ; Female ; Fetal Proteins - genetics ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry - methods ; Male ; Medical sciences ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Pharmacology. Drug treatments ; Prognosis ; Prognostic marker ; Survival analysis ; T gene-box ; T-Box Domain Proteins - genetics ; Tissue micro array ; Transcription Factors - metabolism ; Treatment Outcome ; Tumors</subject><ispartof>European journal of cancer (1990), 2011-05, Vol.47 (7), p.1080-1085</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-2a88bfd0812cc6e90875823952dd750f35916df279cffd70ed6694bf1412fc183</citedby><cites>FETCH-LOGICAL-c506t-2a88bfd0812cc6e90875823952dd750f35916df279cffd70ed6694bf1412fc183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejca.2010.11.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24098760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21220197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kilic, Nerbil</creatorcontrib><creatorcontrib>Feldhaus, Susanne</creatorcontrib><creatorcontrib>Kilic, Ergin</creatorcontrib><creatorcontrib>Tennstedt, Pierre</creatorcontrib><creatorcontrib>Wicklein, Daniel</creatorcontrib><creatorcontrib>Wasielewski, Reinhard von</creatorcontrib><creatorcontrib>Viebahn, Christoph</creatorcontrib><creatorcontrib>Kreipe, Hans</creatorcontrib><creatorcontrib>Schumacher, Udo</creatorcontrib><title>Brachyury expression predicts poor prognosis at early stages of colorectal cancer</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Abstract Although survival rates of colon cancer patients diagnosed at an early stage (T1-2N0M0; Dukes A) vary considerably according to the studies cited, several studies indicate development of distant metastases already occurring in a considerable percentage of these patients leading to the death of the patients. This particular high risk group cannot be identified properly as no marker exists to identify these patients. As the Wnt/Win pathway plays a crucial role in metastasis formation in colorectal carcinoma, we analysed whether the transcription factor brachyury critically involved in this pathway may predict metastasis formation in these patients. The expression of brachyury-homologous (T) was immunohistochemically analysed in 748 patients and the data were correlated with classical and newer prognostic markers in colorectal cancer. Early stages colorectal cancer patients (T1-2N0M0, Dukes A) showed a significantly decreased survival when brachyury was expressed in the tumour tissue while no correlation was observed in later tumour stages. Hence a subset of colorectal cancers exists in which the ability to metastasise is already present at early stages of tumour growth and this high risk group can now be detected by immunohistochemistry.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brachyury transcription factor</subject><subject>Cell Separation</subject><subject>Colorectal adenocarcinoma</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Female</subject><subject>Fetal Proteins - genetics</subject><subject>Flow Cytometry</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Prognostic marker</subject><subject>Survival analysis</subject><subject>T gene-box</subject><subject>T-Box Domain Proteins - genetics</subject><subject>Tissue micro array</subject><subject>Transcription Factors - metabolism</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuLFDEQh4Mo7uzoP-BB-iKeeqxKvxIQYV3WByyIqOeQyWNN29MZU91i__emmVHBg6c8-H6VyleMPUHYIWD7ot-53ugdh_UCd4DNPbZB0ckSRMPvsw3IRpYCannBLol6AOhEDQ_ZBUeeU7LbsI-vkzZflzkthft5TI4oxLHIGxvMRMUxxpRP8W6MFKjQU-F0GpaCJn3nqIi-MHGIyZlJD4XRo3HpEXvg9UDu8Xndsi9vbj5fvytvP7x9f311W5oG2qnkWoi9tyCQG9M6CaJrBK9kw63tGvBVI7G1nnfSeG87cLZtZb33WCP3BkW1Zc9PdXN732dHkzoEMm4Y9OjiTEq0UMm2abpM8hNpUiRKzqtjCgedFoWgVpOqV6tJtZpUiCqbzKGn5_Lz_uDsn8hvdRl4dgY0GT34lH8f6C9XgxRd7mHLXp44l2X8CC4pMsFlUzas3pSN4f99vPonboYwhvziN7c46uOcxqxZoSKuQH1aZ76OHAEQUbbVLwp0poI</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Kilic, Nerbil</creator><creator>Feldhaus, Susanne</creator><creator>Kilic, Ergin</creator><creator>Tennstedt, Pierre</creator><creator>Wicklein, Daniel</creator><creator>Wasielewski, Reinhard von</creator><creator>Viebahn, Christoph</creator><creator>Kreipe, Hans</creator><creator>Schumacher, Udo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Brachyury expression predicts poor prognosis at early stages of colorectal cancer</title><author>Kilic, Nerbil ; Feldhaus, Susanne ; Kilic, Ergin ; Tennstedt, Pierre ; Wicklein, Daniel ; Wasielewski, Reinhard von ; Viebahn, Christoph ; Kreipe, Hans ; Schumacher, Udo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-2a88bfd0812cc6e90875823952dd750f35916df279cffd70ed6694bf1412fc183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brachyury transcription factor</topic><topic>Cell Separation</topic><topic>Colorectal adenocarcinoma</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Female</topic><topic>Fetal Proteins - genetics</topic><topic>Flow Cytometry</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Prognostic marker</topic><topic>Survival analysis</topic><topic>T gene-box</topic><topic>T-Box Domain Proteins - genetics</topic><topic>Tissue micro array</topic><topic>Transcription Factors - metabolism</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kilic, Nerbil</creatorcontrib><creatorcontrib>Feldhaus, Susanne</creatorcontrib><creatorcontrib>Kilic, Ergin</creatorcontrib><creatorcontrib>Tennstedt, Pierre</creatorcontrib><creatorcontrib>Wicklein, Daniel</creatorcontrib><creatorcontrib>Wasielewski, Reinhard von</creatorcontrib><creatorcontrib>Viebahn, Christoph</creatorcontrib><creatorcontrib>Kreipe, Hans</creatorcontrib><creatorcontrib>Schumacher, Udo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kilic, Nerbil</au><au>Feldhaus, Susanne</au><au>Kilic, Ergin</au><au>Tennstedt, Pierre</au><au>Wicklein, Daniel</au><au>Wasielewski, Reinhard von</au><au>Viebahn, Christoph</au><au>Kreipe, Hans</au><au>Schumacher, Udo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brachyury expression predicts poor prognosis at early stages of colorectal cancer</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>47</volume><issue>7</issue><spage>1080</spage><epage>1085</epage><pages>1080-1085</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Abstract Although survival rates of colon cancer patients diagnosed at an early stage (T1-2N0M0; Dukes A) vary considerably according to the studies cited, several studies indicate development of distant metastases already occurring in a considerable percentage of these patients leading to the death of the patients. This particular high risk group cannot be identified properly as no marker exists to identify these patients. As the Wnt/Win pathway plays a crucial role in metastasis formation in colorectal carcinoma, we analysed whether the transcription factor brachyury critically involved in this pathway may predict metastasis formation in these patients. The expression of brachyury-homologous (T) was immunohistochemically analysed in 748 patients and the data were correlated with classical and newer prognostic markers in colorectal cancer. Early stages colorectal cancer patients (T1-2N0M0, Dukes A) showed a significantly decreased survival when brachyury was expressed in the tumour tissue while no correlation was observed in later tumour stages. 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| ispartof | European journal of cancer (1990), 2011-05, Vol.47 (7), p.1080-1085 |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Brachyury transcription factor Cell Separation Colorectal adenocarcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Female Fetal Proteins - genetics Flow Cytometry Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry - methods Male Medical sciences Middle Aged Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Prognosis Prognostic marker Survival analysis T gene-box T-Box Domain Proteins - genetics Tissue micro array Transcription Factors - metabolism Treatment Outcome Tumors |
| title | Brachyury expression predicts poor prognosis at early stages of colorectal cancer |
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