association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia

The aim of this study was to evaluate the association of polymorphisms in genes encoding three key proteins of DNA base excision repair (BER): the OGG1 Ser326Cys, the MUTYH Tyr165Cys and the XRCC1 Arg399Gln with the risk of childhood acute lymphoblastic leukemia (ALL). Our study included 97 children...

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Veröffentlicht in:	Molecular biology reports 2011, Vol.38 (1), p.445-451
Hauptverfasser:	Stanczyk, M, Sliwinski, T, Cuchra, M, Zubowska, M, Bielecka-Kowalska, A, Kowalski, M, Szemraj, J, Mlynarski, W, Majsterek, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphatic leukemia Age Animal Anatomy Animal Biochemistry Base excision repair Biomedical and Life Sciences Cancer Child Childhood acute lymphoblastic leukemia Children Deoxyribonucleic acid DNA DNA Glycosylases - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Female Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Histology Humans Leukemia Life Sciences Male Morphology MUTYH OGG1 OGG1 protein Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Restriction fragment length polymorphism Risk Factors Single-nucleotide polymorphism X-ray Repair Cross Complementing Protein 1 XRCC1 XRCC1 protein
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