Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis
Proinflammatory cytokines interleukin-6 (IL-6), interferon-γ (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(−308)A of TNF, A(+874)T of IFNG, and G(−174)C of IL-6 on the producti...
Gespeichert in:
| Veröffentlicht in: | Molecular biology (New York) 2010-10, Vol.44 (5), p.728-733 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 733 |
|---|---|
| container_issue | 5 |
| container_start_page | 728 |
| container_title | Molecular biology (New York) |
| container_volume | 44 |
| creator | Makarycheva, O. Yu Tsareva, E. Yu Sudomoina, M. A Kulakova, O. G Bykova, O. V Gol'tsova, N. V Kuzenkova, L. M Boiko, A. N Favorova, O. O |
| description | Proinflammatory cytokines interleukin-6 (IL-6), interferon-γ (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(−308)A of TNF, A(+874)T of IFNG, and G(−174)C of IL-6 on the production of these cytokines, we investigated the relation of these polymorphisms with multiple sclerosis. Linkage and association of alleles of these genes with multiple sclerosis were analyzed by transmission disequilibrium test. In a group of 104 nuclear families of Russian ethnicity, the TNF*(−308)A allele was more frequently transmitted from healthy heterozygous parents to affected children (p = 0.01). Linkage/association of IFNG and IL-6 alleles with multiple sclerosis was not detected. Thus, the data obtained indicate that TNF is involved in susceptibility to multiple sclerosis in Russians. |
| doi_str_mv | 10.1134/S0026893310050079 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_860391088</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2189196851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-df204f26774be87174842aab60c219af2e028d8bb98967197a6470889f47f0cc3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWD9-gCeDFy-uTpJtPo4ithaKHtRzSNOkRnc3Ndki_femVhAUvMwc5nmGmRehEwKXhLD66hGAcqkYIwBDAKF20IBwkBWj9XAXDTbjajPfRwc5vwIUjtABctPQvZmFw6abY5NztMH0IXY4erxMMXS-MW1r-pjW2K77-BY6l_HCbepkWvELPBndj7_sp_sR_gj9C25XTR-WjcPZNi7FHPIR2vOmye74ux-i59Ht081dNX0YT26up5VlgvTV3FOoPeVC1DMnBRG1rKkxMw6WEmU8dUDlXM5mSiouiBKG1wKkVL4WHqxlh-h8u7ec_r5yuddtyNY1jelcXGUtOTBFilHIs1_ka1ylrhynheBDoRRnBSJbyJYvcnJeL1NoTVprAnoTu_4Te3Ho1smF7RYu_Sz-TzrdSt5EbRYpZP38SIEwIFIpqoB9AvZRi5I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>776579963</pqid></control><display><type>article</type><title>Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis</title><source>SpringerNature Journals</source><creator>Makarycheva, O. Yu ; Tsareva, E. Yu ; Sudomoina, M. A ; Kulakova, O. G ; Bykova, O. V ; Gol'tsova, N. V ; Kuzenkova, L. M ; Boiko, A. N ; Favorova, O. O</creator><creatorcontrib>Makarycheva, O. Yu ; Tsareva, E. Yu ; Sudomoina, M. A ; Kulakova, O. G ; Bykova, O. V ; Gol'tsova, N. V ; Kuzenkova, L. M ; Boiko, A. N ; Favorova, O. O</creatorcontrib><description>Proinflammatory cytokines interleukin-6 (IL-6), interferon-γ (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(−308)A of TNF, A(+874)T of IFNG, and G(−174)C of IL-6 on the production of these cytokines, we investigated the relation of these polymorphisms with multiple sclerosis. Linkage and association of alleles of these genes with multiple sclerosis were analyzed by transmission disequilibrium test. In a group of 104 nuclear families of Russian ethnicity, the TNF*(−308)A allele was more frequently transmitted from healthy heterozygous parents to affected children (p = 0.01). Linkage/association of IFNG and IL-6 alleles with multiple sclerosis was not detected. Thus, the data obtained indicate that TNF is involved in susceptibility to multiple sclerosis in Russians.</description><identifier>ISSN: 0026-8933</identifier><identifier>EISSN: 1608-3245</identifier><identifier>DOI: 10.1134/S0026893310050079</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : SP MAIK Nauka/Interperiodica</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biosynthesis ; Children ; Cytokines ; Families & family life ; Genomics and Transcriptomics ; Human Genetics ; Life Sciences ; Multiple sclerosis ; Population genetics</subject><ispartof>Molecular biology (New York), 2010-10, Vol.44 (5), p.728-733</ispartof><rights>Pleiades Publishing, Ltd. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-df204f26774be87174842aab60c219af2e028d8bb98967197a6470889f47f0cc3</citedby><cites>FETCH-LOGICAL-c371t-df204f26774be87174842aab60c219af2e028d8bb98967197a6470889f47f0cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0026893310050079$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0026893310050079$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Makarycheva, O. Yu</creatorcontrib><creatorcontrib>Tsareva, E. Yu</creatorcontrib><creatorcontrib>Sudomoina, M. A</creatorcontrib><creatorcontrib>Kulakova, O. G</creatorcontrib><creatorcontrib>Bykova, O. V</creatorcontrib><creatorcontrib>Gol'tsova, N. V</creatorcontrib><creatorcontrib>Kuzenkova, L. M</creatorcontrib><creatorcontrib>Boiko, A. N</creatorcontrib><creatorcontrib>Favorova, O. O</creatorcontrib><title>Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis</title><title>Molecular biology (New York)</title><addtitle>Mol Biol</addtitle><description>Proinflammatory cytokines interleukin-6 (IL-6), interferon-γ (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(−308)A of TNF, A(+874)T of IFNG, and G(−174)C of IL-6 on the production of these cytokines, we investigated the relation of these polymorphisms with multiple sclerosis. Linkage and association of alleles of these genes with multiple sclerosis were analyzed by transmission disequilibrium test. In a group of 104 nuclear families of Russian ethnicity, the TNF*(−308)A allele was more frequently transmitted from healthy heterozygous parents to affected children (p = 0.01). Linkage/association of IFNG and IL-6 alleles with multiple sclerosis was not detected. Thus, the data obtained indicate that TNF is involved in susceptibility to multiple sclerosis in Russians.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Children</subject><subject>Cytokines</subject><subject>Families & family life</subject><subject>Genomics and Transcriptomics</subject><subject>Human Genetics</subject><subject>Life Sciences</subject><subject>Multiple sclerosis</subject><subject>Population genetics</subject><issn>0026-8933</issn><issn>1608-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LAzEQhoMoWD9-gCeDFy-uTpJtPo4ithaKHtRzSNOkRnc3Ndki_femVhAUvMwc5nmGmRehEwKXhLD66hGAcqkYIwBDAKF20IBwkBWj9XAXDTbjajPfRwc5vwIUjtABctPQvZmFw6abY5NztMH0IXY4erxMMXS-MW1r-pjW2K77-BY6l_HCbepkWvELPBndj7_sp_sR_gj9C25XTR-WjcPZNi7FHPIR2vOmye74ux-i59Ht081dNX0YT26up5VlgvTV3FOoPeVC1DMnBRG1rKkxMw6WEmU8dUDlXM5mSiouiBKG1wKkVL4WHqxlh-h8u7ec_r5yuddtyNY1jelcXGUtOTBFilHIs1_ka1ylrhynheBDoRRnBSJbyJYvcnJeL1NoTVprAnoTu_4Te3Ho1smF7RYu_Sz-TzrdSt5EbRYpZP38SIEwIFIpqoB9AvZRi5I</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Makarycheva, O. Yu</creator><creator>Tsareva, E. Yu</creator><creator>Sudomoina, M. A</creator><creator>Kulakova, O. G</creator><creator>Bykova, O. V</creator><creator>Gol'tsova, N. V</creator><creator>Kuzenkova, L. M</creator><creator>Boiko, A. N</creator><creator>Favorova, O. O</creator><general>Dordrecht : SP MAIK Nauka/Interperiodica</general><general>SP MAIK Nauka/Interperiodica</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20101001</creationdate><title>Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis</title><author>Makarycheva, O. Yu ; Tsareva, E. Yu ; Sudomoina, M. A ; Kulakova, O. G ; Bykova, O. V ; Gol'tsova, N. V ; Kuzenkova, L. M ; Boiko, A. N ; Favorova, O. O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-df204f26774be87174842aab60c219af2e028d8bb98967197a6470889f47f0cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Children</topic><topic>Cytokines</topic><topic>Families & family life</topic><topic>Genomics and Transcriptomics</topic><topic>Human Genetics</topic><topic>Life Sciences</topic><topic>Multiple sclerosis</topic><topic>Population genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Makarycheva, O. Yu</creatorcontrib><creatorcontrib>Tsareva, E. Yu</creatorcontrib><creatorcontrib>Sudomoina, M. A</creatorcontrib><creatorcontrib>Kulakova, O. G</creatorcontrib><creatorcontrib>Bykova, O. V</creatorcontrib><creatorcontrib>Gol'tsova, N. V</creatorcontrib><creatorcontrib>Kuzenkova, L. M</creatorcontrib><creatorcontrib>Boiko, A. N</creatorcontrib><creatorcontrib>Favorova, O. O</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular biology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Makarycheva, O. Yu</au><au>Tsareva, E. Yu</au><au>Sudomoina, M. A</au><au>Kulakova, O. G</au><au>Bykova, O. V</au><au>Gol'tsova, N. V</au><au>Kuzenkova, L. M</au><au>Boiko, A. N</au><au>Favorova, O. O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis</atitle><jtitle>Molecular biology (New York)</jtitle><stitle>Mol Biol</stitle><date>2010-10-01</date><risdate>2010</risdate><volume>44</volume><issue>5</issue><spage>728</spage><epage>733</epage><pages>728-733</pages><issn>0026-8933</issn><eissn>1608-3245</eissn><abstract>Proinflammatory cytokines interleukin-6 (IL-6), interferon-γ (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(−308)A of TNF, A(+874)T of IFNG, and G(−174)C of IL-6 on the production of these cytokines, we investigated the relation of these polymorphisms with multiple sclerosis. Linkage and association of alleles of these genes with multiple sclerosis were analyzed by transmission disequilibrium test. In a group of 104 nuclear families of Russian ethnicity, the TNF*(−308)A allele was more frequently transmitted from healthy heterozygous parents to affected children (p = 0.01). Linkage/association of IFNG and IL-6 alleles with multiple sclerosis was not detected. Thus, the data obtained indicate that TNF is involved in susceptibility to multiple sclerosis in Russians.</abstract><cop>Dordrecht</cop><pub>Dordrecht : SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S0026893310050079</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-8933 |
| ispartof | Molecular biology (New York), 2010-10, Vol.44 (5), p.728-733 |
| issn | 0026-8933 1608-3245 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_860391088 |
| source | SpringerNature Journals |
| subjects | Biochemistry Biomedical and Life Sciences Biosynthesis Children Cytokines Families & family life Genomics and Transcriptomics Human Genetics Life Sciences Multiple sclerosis Population genetics |
| title | Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A36%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Linkage%20and%20association%20of%20proinflammatory%20cytokines%20genes%20IL-6,%20IFNG%20and%20TNF%20with%20multiple%20sclerosis&rft.jtitle=Molecular%20biology%20(New%20York)&rft.au=Makarycheva,%20O.%20Yu&rft.date=2010-10-01&rft.volume=44&rft.issue=5&rft.spage=728&rft.epage=733&rft.pages=728-733&rft.issn=0026-8933&rft.eissn=1608-3245&rft_id=info:doi/10.1134/S0026893310050079&rft_dat=%3Cproquest_cross%3E2189196851%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=776579963&rft_id=info:pmid/&rfr_iscdi=true |