Influence of operating conditions and vessel size on oxygen transfer during cellulase production
The production of low-cost cellulase enzyme is a key step in the development of an enzymatic-based process for conversion of lignocellulosic biomass to ethanol. Although abundant information is available on cellulase production, little of this work has examined oxygen transfer. We investigated oxyge...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2001, Vol.91-93 (1-9), p.627-642 |
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| container_title | Applied biochemistry and biotechnology |
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| creator | SCHELL, Daniel J FARMER, Jody HAMILTON, Jenny LYONS, Bob MCMILLAN, James D SAEZ, Juan C THOLUDUR, Arun |
| description | The production of low-cost cellulase enzyme is a key step in the development of an enzymatic-based process for conversion of lignocellulosic biomass to ethanol. Although abundant information is available on cellulase production, little of this work has examined oxygen transfer. We investigated oxygen transfer during the growth of Trichoderma reesei, a cellulase-producing microorganism, on soluble and insoluble substrates in vessel sizes from 7 to 9000 L. Oxygen uptake rates and volumetric mass transfer coefficients (kLa) were determined using mass spectroscopy to measure off gas composition. Experimentally measured kLa values were found to compare favorably with a kLa correlation available in the literature for a non-Newtonian fermentation broth during the period of heavy cell growth. |
| doi_str_mv | 10.1385/abab:91-93:1-9:627 |
| format | Article |
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Although abundant information is available on cellulase production, little of this work has examined oxygen transfer. We investigated oxygen transfer during the growth of Trichoderma reesei, a cellulase-producing microorganism, on soluble and insoluble substrates in vessel sizes from 7 to 9000 L. Oxygen uptake rates and volumetric mass transfer coefficients (kLa) were determined using mass spectroscopy to measure off gas composition. Experimentally measured kLa values were found to compare favorably with a kLa correlation available in the literature for a non-Newtonian fermentation broth during the period of heavy cell growth.</description><identifier>ISSN: 0273-2289</identifier><identifier>EISSN: 1559-0291</identifier><identifier>EISSN: 0273-2289</identifier><identifier>DOI: 10.1385/abab:91-93:1-9:627</identifier><identifier>PMID: 11963891</identifier><identifier>CODEN: ABIBDL</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Biomass ; Bioreactors ; Biotechnology ; Cellulase - biosynthesis ; Cellulose - metabolism ; Enzyme engineering ; Ethanol ; Ethanol - metabolism ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Gases ; Hypocrea jecorina ; Influence ; Lignin - metabolism ; Mass spectroscopy ; Mass transfer ; Methods. Procedures. Technologies ; Oxygen ; Oxygen - metabolism ; Oxygen transfer ; Oxygen uptake ; Pilot Projects ; Production of selected enzymes ; Solubility ; Substrate Specificity ; Trichoderma - enzymology ; Trichoderma - growth & development</subject><ispartof>Applied biochemistry and biotechnology, 2001, Vol.91-93 (1-9), p.627-642</ispartof><rights>2001 INIST-CNRS</rights><rights>Humana Press Inc. 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-5129a6ad23b7bfe985cc32a077b38548cf64bf1808c85c5fec60c6d2391e57883</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4010,4036,4037,23909,23910,25118,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1128785$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11963891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHELL, Daniel J</creatorcontrib><creatorcontrib>FARMER, Jody</creatorcontrib><creatorcontrib>HAMILTON, Jenny</creatorcontrib><creatorcontrib>LYONS, Bob</creatorcontrib><creatorcontrib>MCMILLAN, James D</creatorcontrib><creatorcontrib>SAEZ, Juan C</creatorcontrib><creatorcontrib>THOLUDUR, Arun</creatorcontrib><title>Influence of operating conditions and vessel size on oxygen transfer during cellulase production</title><title>Applied biochemistry and biotechnology</title><addtitle>Appl Biochem Biotechnol</addtitle><description>The production of low-cost cellulase enzyme is a key step in the development of an enzymatic-based process for conversion of lignocellulosic biomass to ethanol. Although abundant information is available on cellulase production, little of this work has examined oxygen transfer. We investigated oxygen transfer during the growth of Trichoderma reesei, a cellulase-producing microorganism, on soluble and insoluble substrates in vessel sizes from 7 to 9000 L. Oxygen uptake rates and volumetric mass transfer coefficients (kLa) were determined using mass spectroscopy to measure off gas composition. Experimentally measured kLa values were found to compare favorably with a kLa correlation available in the literature for a non-Newtonian fermentation broth during the period of heavy cell growth.</description><subject>Biological and medical sciences</subject><subject>Biomass</subject><subject>Bioreactors</subject><subject>Biotechnology</subject><subject>Cellulase - biosynthesis</subject><subject>Cellulose - metabolism</subject><subject>Enzyme engineering</subject><subject>Ethanol</subject><subject>Ethanol - metabolism</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gases</subject><subject>Hypocrea jecorina</subject><subject>Influence</subject><subject>Lignin - metabolism</subject><subject>Mass spectroscopy</subject><subject>Mass transfer</subject><subject>Methods. Procedures. Technologies</subject><subject>Oxygen</subject><subject>Oxygen - metabolism</subject><subject>Oxygen transfer</subject><subject>Oxygen uptake</subject><subject>Pilot Projects</subject><subject>Production of selected enzymes</subject><subject>Solubility</subject><subject>Substrate Specificity</subject><subject>Trichoderma - enzymology</subject><subject>Trichoderma - growth & development</subject><issn>0273-2289</issn><issn>1559-0291</issn><issn>0273-2289</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9vEzEQxa0K1IbQL9ADshCC04LHjtd2bmnFn0qVuNCz6_WOq602drB3Ucunx6GRWnHgMj7M783M8yPkDNhHEFp-cp3r1gYaI9a1rFuujsgCpDQN4wZekAXjSjSca3NCXpVyxxhwLdUxOQEwrdAGFuTmMoZxxuiRpkDTDrObhnhLfYr9MA0pFupiT39hKTjSMvyuXKTp_uEWI52yiyVgpv2c_4pwHOfRFaS7nPrZ7_WvycvgxoKnh3dJrr98_nHxrbn6_vXyYnPV-JUUUyOBG9e6notOdQGNlt4L7phSXbW60j60qy6AZtrXlgzoW-bbihtAqbQWS_LhcW5d_XPGMtntUPYHuYhpLla3TBimqu8lef9fUoEAUExU8O0_4F2ac6wuLBhVmZWACvFHyOdUSsZgd3nYuvxggdl9THZzvjm3BqwRthZbY6qiN4fJc7fF_klyyKUC7w6AK96NoX60H8ozjmulpfgDMCybqw</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>SCHELL, Daniel J</creator><creator>FARMER, Jody</creator><creator>HAMILTON, Jenny</creator><creator>LYONS, Bob</creator><creator>MCMILLAN, James D</creator><creator>SAEZ, Juan C</creator><creator>THOLUDUR, Arun</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>2001</creationdate><title>Influence of operating conditions and vessel size on oxygen transfer during cellulase production</title><author>SCHELL, Daniel J ; FARMER, Jody ; HAMILTON, Jenny ; LYONS, Bob ; MCMILLAN, James D ; SAEZ, Juan C ; THOLUDUR, Arun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-5129a6ad23b7bfe985cc32a077b38548cf64bf1808c85c5fec60c6d2391e57883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Biomass</topic><topic>Bioreactors</topic><topic>Biotechnology</topic><topic>Cellulase - biosynthesis</topic><topic>Cellulose - metabolism</topic><topic>Enzyme engineering</topic><topic>Ethanol</topic><topic>Ethanol - metabolism</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gases</topic><topic>Hypocrea jecorina</topic><topic>Influence</topic><topic>Lignin - metabolism</topic><topic>Mass spectroscopy</topic><topic>Mass transfer</topic><topic>Methods. Procedures. 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| ispartof | Applied biochemistry and biotechnology, 2001, Vol.91-93 (1-9), p.627-642 |
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| subjects | Biological and medical sciences Biomass Bioreactors Biotechnology Cellulase - biosynthesis Cellulose - metabolism Enzyme engineering Ethanol Ethanol - metabolism Fermentation Fundamental and applied biological sciences. Psychology Gases Hypocrea jecorina Influence Lignin - metabolism Mass spectroscopy Mass transfer Methods. Procedures. Technologies Oxygen Oxygen - metabolism Oxygen transfer Oxygen uptake Pilot Projects Production of selected enzymes Solubility Substrate Specificity Trichoderma - enzymology Trichoderma - growth & development |
| title | Influence of operating conditions and vessel size on oxygen transfer during cellulase production |
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