Mixed testicular germ cell tumour in a patient with previous pineal germinoma
Germ cell tumours (GCT) are a relatively common malignancy in men aged 15–35 years. They occur most frequently in the gonads, but 3–5% have extragonadal origin, mainly in the pineal gland, neurohypophysis, mediastinum and retroperitoneum. Although intracranial germinomas may present with synchronous...
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| Veröffentlicht in: | Journal of neuro-oncology 2011, Vol.101 (1), p.125-128 |
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| container_title | Journal of neuro-oncology |
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| creator | Silva, Vanessa B. Azevedo, Ana L. Costa, Ilda M. Mafra, Manuela S. Passos-Coelho, José L. Bravo-Marques, José M. |
| description | Germ cell tumours (GCT) are a relatively common malignancy in men aged 15–35 years. They occur most frequently in the gonads, but 3–5% have extragonadal origin, mainly in the pineal gland, neurohypophysis, mediastinum and retroperitoneum. Although intracranial germinomas may present with synchronous midline lesions, development of metachronous testicular germ cell primaries seems to be extremely rare, and confirmed dissemination of intracranial GCT to the testes has never been reported. We report the case of a 32-year-old man, with previously treated pineal germinoma at age 16 years, who later developed mixed GCT of the left testis. |
| doi_str_mv | 10.1007/s11060-010-0213-x |
| format | Article |
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They occur most frequently in the gonads, but 3–5% have extragonadal origin, mainly in the pineal gland, neurohypophysis, mediastinum and retroperitoneum. Although intracranial germinomas may present with synchronous midline lesions, development of metachronous testicular germ cell primaries seems to be extremely rare, and confirmed dissemination of intracranial GCT to the testes has never been reported. We report the case of a 32-year-old man, with previously treated pineal germinoma at age 16 years, who later developed mixed GCT of the left testis.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-010-0213-x</identifier><identifier>PMID: 20461442</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Case Report ; Germinoma - pathology ; Germinoma - radiotherapy ; Germinoma - surgery ; Humans ; Male ; Medicine ; Medicine & Public Health ; Neoplasms, Germ Cell and Embryonal - drug therapy ; Neoplasms, Germ Cell and Embryonal - pathology ; Neoplasms, Germ Cell and Embryonal - surgery ; Neoplasms, Second Primary - drug therapy ; Neoplasms, Second Primary - pathology ; Neoplasms, Second Primary - surgery ; Neurology ; Oncology ; Orchiectomy ; Pinealoma - pathology ; Pinealoma - radiotherapy ; Pinealoma - surgery ; Testicular Neoplasms - drug therapy ; Testicular Neoplasms - pathology ; Testicular Neoplasms - surgery</subject><ispartof>Journal of neuro-oncology, 2011, Vol.101 (1), p.125-128</ispartof><rights>Springer Science+Business Media, LLC. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-f601aad7c50fb25f4ac17b6e17b3834470151d0243bae2455781b2809df15c933</citedby><cites>FETCH-LOGICAL-c402t-f601aad7c50fb25f4ac17b6e17b3834470151d0243bae2455781b2809df15c933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-010-0213-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-010-0213-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20461442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Vanessa B.</creatorcontrib><creatorcontrib>Azevedo, Ana L.</creatorcontrib><creatorcontrib>Costa, Ilda M.</creatorcontrib><creatorcontrib>Mafra, Manuela S.</creatorcontrib><creatorcontrib>Passos-Coelho, José L.</creatorcontrib><creatorcontrib>Bravo-Marques, José M.</creatorcontrib><title>Mixed testicular germ cell tumour in a patient with previous pineal germinoma</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Germ cell tumours (GCT) are a relatively common malignancy in men aged 15–35 years. They occur most frequently in the gonads, but 3–5% have extragonadal origin, mainly in the pineal gland, neurohypophysis, mediastinum and retroperitoneum. Although intracranial germinomas may present with synchronous midline lesions, development of metachronous testicular germ cell primaries seems to be extremely rare, and confirmed dissemination of intracranial GCT to the testes has never been reported. 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| subjects | Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Case Report Germinoma - pathology Germinoma - radiotherapy Germinoma - surgery Humans Male Medicine Medicine & Public Health Neoplasms, Germ Cell and Embryonal - drug therapy Neoplasms, Germ Cell and Embryonal - pathology Neoplasms, Germ Cell and Embryonal - surgery Neoplasms, Second Primary - drug therapy Neoplasms, Second Primary - pathology Neoplasms, Second Primary - surgery Neurology Oncology Orchiectomy Pinealoma - pathology Pinealoma - radiotherapy Pinealoma - surgery Testicular Neoplasms - drug therapy Testicular Neoplasms - pathology Testicular Neoplasms - surgery |
| title | Mixed testicular germ cell tumour in a patient with previous pineal germinoma |
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