Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation

Tert-butylhydroquinone (tBHQ), the major metabolite of butylated hydroxyanisole, induces an antioxidant response through the redox-sensitive transcription factor, nuclear factor-E2-related factor-2 (Nrf2). However, the mechanism by which tBHQ induces Nrf2 activity is not entirely understood. Here, w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell biology and toxicology 2010-12, Vol.26 (6), p.541-551
Hauptverfasser:	Imhoff, Barry R, Hansen, Jason M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Biochemistry Biomedical and Life Sciences Cell Biology Cellular biology Chemical compounds Gene expression Gene Expression Regulation - drug effects HeLa Cells Humans Hydroquinones - toxicity Life Sciences Metabolites Mitochondria Mitochondria - drug effects Mitochondria - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Oxidation Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Reactive Oxygen Species - metabolism Tert-butylhyrdroquinone Thioredoxin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!