Inhibition of nitric oxide-induced apoptosis by nicotine in oral epithelial cells

Development of oral cancer is clearly linked to the usage of smokeless tobacco. The molecular mechanisms involved in this process are however not well understood. Toward this goal, we investigated the effect of smokeless tobacco exposure on apoptosis of oral epithelial cells. Exposure of oral epithe...

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Veröffentlicht in:	Molecular and cellular biochemistry 2007-11, Vol.305 (1-2), p.113-121
Hauptverfasser:	Banerjee, Abhijit G, Gopalakrishnan, Velliyur K, Vishwanatha, Jamboor K
Format:	Artikel
Sprache:	eng
Schlagworte:	3-NT Animals Apoptosis Apoptosis - drug effects Cancer Carcinogenesis Carcinoma - chemically induced Carcinoma - metabolism Carcinoma - pathology Cells Cellular biology Cricetinae Dose-Response Relationship, Drug Epithelial Cells - drug effects fibroblasts HCPC-1 Inhibition Mesocricetus Mouth Mucosa - drug effects Mouth Neoplasms - chemically induced Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Nicotine Nicotine - toxicity Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Nitric Oxide - physiology Nitrotyrosination Oral epithelial cells Oxidative Stress - drug effects Peroxynitrite radical Peroxynitrous Acid - metabolism reactive oxygen species RPDL Tobacco Tobacco, Smokeless - toxicity Tumor Cells, Cultured
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