High‐phosphate‐induced calcification is related to SM22α promoter methylation in vascular smooth muscle cells

Hyperphosphatemia is closely related to vascular calcification in patients with chronic kidney disease. Vascular smooth muscle cells (VSMCs) exposed to high phosphate concentrations in vitro undergo phenotypic transition to osteoblast‐like cells. Mechanisms underlying this transdifferentiation are n...

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Veröffentlicht in:	Journal of bone and mineral research 2010-09, Vol.25 (9), p.1996-2005
Hauptverfasser:	de Oca, Addy Montes, Madueño, Juan A, Martinez‐Moreno, Julio M, Guerrero, Fatima, Muñoz‐Castañeda, Juan, Rodriguez‐Ortiz, Marien E, Mendoza, Francisco J, Almaden, Yolanda, Lopez, Ignacio, Rodriguez, Mariano, Aguilera‐Tejero, Escolastico
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Calcinosis - complications DNA Methylation DNA Primers Fundamental and applied biological sciences. Psychology Humans methylation Microfilament Proteins - genetics Muscle Proteins - genetics Muscle, Smooth, Vascular - metabolism phosphate Promoter Regions, Genetic Rats Skeleton and joints SM22α vascular calcification Vertebrates: osteoarticular system, musculoskeletal system VSMCs
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