Ganglioside GD3 monoclonal antibody-induced paxillin tyrosine phosphorylation and filamentous actin assembly in cerebellar growth cones

J. Neurochem. (2011) 116, 845-850. ABSTRACT: We have demonstrated that antibody to ganglioside GD3 (R24) immunoprecipitates src-family tyrosine kinase Lyn from primary cerebellar granule cells and R24 treatment of the intact cells induces Lyn activation and rapid tyrosine phosphorylation of several...

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Veröffentlicht in:	Journal of neurochemistry 2011-03, Vol.116 (5), p.845-850
Hauptverfasser:	Yuyama, Kohei, Sekino-Suzuki, Naoko, Yamamoto, Naomasa, Kasahara, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Animals Animals, Newborn Antibodies Antibodies, Monoclonal - pharmacology Axonogenesis Cells, Cultured Cerebellum Cerebellum - cytology Cytology ganglioside GD3 Gangliosides Gangliosides - immunology Granule cells growth cone Growth cones Growth Cones - drug effects Lyn protein Monoclonal antibodies Morphology neurite outgrowth Neurochemistry Neurons - cytology paxillin Paxillin - chemistry Paxillin - metabolism Phosphorylation Phosphorylation - drug effects Protein-tyrosine kinase Proteins Rats Signal transduction Time Factors Tyrosine - metabolism
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