The hypothalamus–pituitary–thyroid axis in teleosts and amphibians: Endocrine disruption and its consequences to natural populations
Teleosts and pond-breeding amphibians may be exposed to a wide variety of anthropogenic, waterborne contaminants that affect the hypothalamus–pituitary–thyroid (HPT) axis. Because thyroid hormone is required for their normal development and reproduction, the potential impact of HPT-disrupting contam...
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Veröffentlicht in: | General and comparative endocrinology 2011-01, Vol.170 (2), p.299-312 |
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description | Teleosts and pond-breeding amphibians may be exposed to a wide variety of anthropogenic, waterborne contaminants that affect the hypothalamus–pituitary–thyroid (HPT) axis. Because thyroid hormone is required for their normal development and reproduction, the potential impact of HPT-disrupting contaminants on natural teleost and amphibian populations raises special concern. There is laboratory evidence indicating that persistent organic pollutants, heavy metals, pharmaceutical and personal care products, agricultural chemicals, and aerospace products may alter HPT activity, development, and reproduction in teleosts and amphibians. However, at present there is no evidence to clearly link contaminant-induced HPT alterations to impairments in teleost or amphibian population health in the field. Also, with the exception of perchlorate for which laboratory studies have shown a direct link between HPT disruption and adverse impacts on development and reproductive physiology, little is known about if or how other HPT-disrupting contaminants affect organismal performance. Future field studies should focus on establishing temporal associations between the presence of HPT-disrupting chemicals, the occurrence of HPT alterations, and adverse effects on development and reproduction in natural populations; as well as determining how complex mixtures of HPT contaminants affect organismal and population health. |
doi_str_mv | 10.1016/j.ygcen.2010.06.001 |
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Because thyroid hormone is required for their normal development and reproduction, the potential impact of HPT-disrupting contaminants on natural teleost and amphibian populations raises special concern. There is laboratory evidence indicating that persistent organic pollutants, heavy metals, pharmaceutical and personal care products, agricultural chemicals, and aerospace products may alter HPT activity, development, and reproduction in teleosts and amphibians. However, at present there is no evidence to clearly link contaminant-induced HPT alterations to impairments in teleost or amphibian population health in the field. Also, with the exception of perchlorate for which laboratory studies have shown a direct link between HPT disruption and adverse impacts on development and reproductive physiology, little is known about if or how other HPT-disrupting contaminants affect organismal performance. 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Because thyroid hormone is required for their normal development and reproduction, the potential impact of HPT-disrupting contaminants on natural teleost and amphibian populations raises special concern. There is laboratory evidence indicating that persistent organic pollutants, heavy metals, pharmaceutical and personal care products, agricultural chemicals, and aerospace products may alter HPT activity, development, and reproduction in teleosts and amphibians. However, at present there is no evidence to clearly link contaminant-induced HPT alterations to impairments in teleost or amphibian population health in the field. Also, with the exception of perchlorate for which laboratory studies have shown a direct link between HPT disruption and adverse impacts on development and reproductive physiology, little is known about if or how other HPT-disrupting contaminants affect organismal performance. Future field studies should focus on establishing temporal associations between the presence of HPT-disrupting chemicals, the occurrence of HPT alterations, and adverse effects on development and reproduction in natural populations; as well as determining how complex mixtures of HPT contaminants affect organismal and population health.</description><subject>adverse effects</subject><subject>agrochemicals</subject><subject>Amphibians</subject><subject>Amphibians - growth & development</subject><subject>Amphibians - physiology</subject><subject>Animals</subject><subject>Development</subject><subject>Endocrine Disruptors - pharmacology</subject><subject>Endocrine System - drug effects</subject><subject>Endocrinology & Metabolism</subject><subject>Fishes</subject><subject>Fishes - growth & development</subject><subject>Fishes - physiology</subject><subject>heavy metals</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Hypothalamus</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - physiology</subject><subject>persistent organic pollutants</subject><subject>personal care products</subject><subject>Pituitary</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - physiology</subject><subject>Population Dynamics</subject><subject>Reproduction</subject><subject>Reproduction - physiology</subject><subject>Teleostei</subject><subject>Thyroid</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiology</subject><subject>thyroid hormones</subject><subject>Thyroid Hormones - physiology</subject><subject>Water Pollutants - pharmacology</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstu1DAUhiMEokPhCZAgO1Yz-JJ4EiQqoapcpEos2q4tX04aD4kdfBzE7LrsnjfkSXA6hQWbbmzr6PuPjv__FMVLSjaUUPF2t9lfG_AbRnKFiA0h9FGxoqSt16KpyONilStiLaqGHBXPEHeEkJoL-rQ4YqQWggu2Km4veyj7_RRSrwY1zvj75tfk0uySivv8Tv0-BmdL9dNh6XyZYICACUvlc3Gceqed8viuPPM2mOg8lNZhnKfkgr-DXIZN8AjfZ_AGsEyh9CrNUQ3lFKZ5UAuKz4snnRoQXtzfx8XVx7PL08_r86-fvpx-OF-bSrRpbZXuaLflrW10BaLqdMu6qqu41vmgnFFS598Z0-mtYEpoEFQpC7qxlGlu-XHx5tB3iiFPhEmODg0Mg_IQZpSNILyp2bZ5mGSMZ3PbOpP8QJoYECN0copuzAZKSuSSldzJu6zkkpUkQuZksurVff9Zj2D_af6Gk4HXB6BTQarr6FBeXeQO9aLe1u1CvD8QkB374SBKNG5x2boIJkkb3AMjnPynN4PzzqjhG-wBd2GOPochqUQmibxYFmrZJ5pXibGq4X8AlHvKjg</recordid><startdate>20110115</startdate><enddate>20110115</enddate><creator>Carr, James A</creator><creator>Patiño, Reynaldo</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20110115</creationdate><title>The hypothalamus–pituitary–thyroid axis in teleosts and amphibians: Endocrine disruption and its consequences to natural populations</title><author>Carr, James A ; Patiño, Reynaldo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-dabf1f739d8b4e64fb92f4f43bbf43132105205ccfb762a6be61aadeb8d12b3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>adverse effects</topic><topic>agrochemicals</topic><topic>Amphibians</topic><topic>Amphibians - growth & development</topic><topic>Amphibians - physiology</topic><topic>Animals</topic><topic>Development</topic><topic>Endocrine Disruptors - pharmacology</topic><topic>Endocrine System - drug effects</topic><topic>Endocrinology & Metabolism</topic><topic>Fishes</topic><topic>Fishes - growth & development</topic><topic>Fishes - physiology</topic><topic>heavy metals</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Hypothalamus</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - physiology</topic><topic>persistent organic pollutants</topic><topic>personal care products</topic><topic>Pituitary</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - physiology</topic><topic>Population Dynamics</topic><topic>Reproduction</topic><topic>Reproduction - physiology</topic><topic>Teleostei</topic><topic>Thyroid</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - physiology</topic><topic>thyroid hormones</topic><topic>Thyroid Hormones - physiology</topic><topic>Water Pollutants - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carr, James A</creatorcontrib><creatorcontrib>Patiño, Reynaldo</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carr, James A</au><au>Patiño, Reynaldo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The hypothalamus–pituitary–thyroid axis in teleosts and amphibians: Endocrine disruption and its consequences to natural populations</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2011-01-15</date><risdate>2011</risdate><volume>170</volume><issue>2</issue><spage>299</spage><epage>312</epage><pages>299-312</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>Teleosts and pond-breeding amphibians may be exposed to a wide variety of anthropogenic, waterborne contaminants that affect the hypothalamus–pituitary–thyroid (HPT) axis. Because thyroid hormone is required for their normal development and reproduction, the potential impact of HPT-disrupting contaminants on natural teleost and amphibian populations raises special concern. There is laboratory evidence indicating that persistent organic pollutants, heavy metals, pharmaceutical and personal care products, agricultural chemicals, and aerospace products may alter HPT activity, development, and reproduction in teleosts and amphibians. However, at present there is no evidence to clearly link contaminant-induced HPT alterations to impairments in teleost or amphibian population health in the field. Also, with the exception of perchlorate for which laboratory studies have shown a direct link between HPT disruption and adverse impacts on development and reproductive physiology, little is known about if or how other HPT-disrupting contaminants affect organismal performance. Future field studies should focus on establishing temporal associations between the presence of HPT-disrupting chemicals, the occurrence of HPT alterations, and adverse effects on development and reproduction in natural populations; as well as determining how complex mixtures of HPT contaminants affect organismal and population health.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20566362</pmid><doi>10.1016/j.ygcen.2010.06.001</doi><tpages>14</tpages></addata></record> |
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subjects | adverse effects agrochemicals Amphibians Amphibians - growth & development Amphibians - physiology Animals Development Endocrine Disruptors - pharmacology Endocrine System - drug effects Endocrinology & Metabolism Fishes Fishes - growth & development Fishes - physiology heavy metals Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Hypothalamus Hypothalamus - drug effects Hypothalamus - physiology persistent organic pollutants personal care products Pituitary Pituitary Gland - drug effects Pituitary Gland - physiology Population Dynamics Reproduction Reproduction - physiology Teleostei Thyroid Thyroid Gland - drug effects Thyroid Gland - physiology thyroid hormones Thyroid Hormones - physiology Water Pollutants - pharmacology |
title | The hypothalamus–pituitary–thyroid axis in teleosts and amphibians: Endocrine disruption and its consequences to natural populations |
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