HLA polymorphisms in Sindhi community in Mumbai, India
Summary Indian population is an amalgamation of various ethnicities, cultural and linguistic diversities, primarily due to marriages within a community. HLA‐A, B and DRB1 alleles and haplotype frequencies were investigated in the Sindhi and compared with Marathi, Gujarati and North Indian population...
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| Veröffentlicht in: | International journal of immunogenetics 2010-10, Vol.37 (5), p.373-377 |
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| container_title | International journal of immunogenetics |
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| creator | Chhaya, S. Desai, S. Saranath, D. |
| description | Summary
Indian population is an amalgamation of various ethnicities, cultural and linguistic diversities, primarily due to marriages within a community. HLA‐A, B and DRB1 alleles and haplotype frequencies were investigated in the Sindhi and compared with Marathi, Gujarati and North Indian population from Mumbai. This work is a part of a larger effort aimed at analysis of the HLA profile of diverse Indian ethnics to establish an umbilical cord stem cell panel in India. HLA polymorphisms at the HLA‐A, B and DRB1 loci were determined in 413 cord blood samples by the molecular method of polymerase chain reaction using sequence‐specific primer amplification. The most frequent alleles included A*01, A*02, A*11 and A*24 at A locus, B*35 and B*40 at B locus and DRB1*07 and DRB1*15 in all the four groups, although the frequency fluctuated in individual communities. HLA‐DRB1*03 was significantly high (P |
| doi_str_mv | 10.1111/j.1744-313X.2010.00936.x |
| format | Article |
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Indian population is an amalgamation of various ethnicities, cultural and linguistic diversities, primarily due to marriages within a community. HLA‐A, B and DRB1 alleles and haplotype frequencies were investigated in the Sindhi and compared with Marathi, Gujarati and North Indian population from Mumbai. This work is a part of a larger effort aimed at analysis of the HLA profile of diverse Indian ethnics to establish an umbilical cord stem cell panel in India. HLA polymorphisms at the HLA‐A, B and DRB1 loci were determined in 413 cord blood samples by the molecular method of polymerase chain reaction using sequence‐specific primer amplification. The most frequent alleles included A*01, A*02, A*11 and A*24 at A locus, B*35 and B*40 at B locus and DRB1*07 and DRB1*15 in all the four groups, although the frequency fluctuated in individual communities. HLA‐DRB1*03 was significantly high (P < 0.05) in the Sindhi. Phylogenetic association using neighbour‐joining tree, based on DA genetic distances for HLA‐A and HLA‐B alleles, indicated that the Sindhis cluster with North Indian and Pakistan Sindhi. The three locus haplotype analysis revealed that A*02‐B*40‐DRB1*15 and A*33‐B*44‐DRB1*07 were common haplotypes in all the groups. The three locus haplotypes found suggest an influence from Caucasian and Oriental populations. The data will be useful in developing an umbilical cord stem cell panel in India. The results will have clinical implications in unrelated umbilical cord stem cell for transplantation in India.</description><identifier>ISSN: 1744-3121</identifier><identifier>EISSN: 1744-313X</identifier><identifier>DOI: 10.1111/j.1744-313X.2010.00936.x</identifier><identifier>PMID: 20518846</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Cord blood ; Data processing ; Dopamine ; Drb1 protein ; Ethnic groups ; Female ; Gene Frequency ; Genetic distance ; Haplotypes ; Histocompatibility antigen HLA ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class II - genetics ; HLA Antigens - genetics ; Humans ; India - ethnology ; Language ; Phylogeny ; Polymerase chain reaction ; Polymorphism, Genetic ; Population genetics ; Primers ; Stem cells ; Umbilical cord</subject><ispartof>International journal of immunogenetics, 2010-10, Vol.37 (5), p.373-377</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2010 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4376-4ca7751c8a7aa45732647ea57e9082eacc0b2dc5d1430d6a9be340aac3814943</citedby><cites>FETCH-LOGICAL-c4376-4ca7751c8a7aa45732647ea57e9082eacc0b2dc5d1430d6a9be340aac3814943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1744-313X.2010.00936.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1744-313X.2010.00936.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20518846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chhaya, S.</creatorcontrib><creatorcontrib>Desai, S.</creatorcontrib><creatorcontrib>Saranath, D.</creatorcontrib><title>HLA polymorphisms in Sindhi community in Mumbai, India</title><title>International journal of immunogenetics</title><addtitle>Int J Immunogenet</addtitle><description>Summary
Indian population is an amalgamation of various ethnicities, cultural and linguistic diversities, primarily due to marriages within a community. HLA‐A, B and DRB1 alleles and haplotype frequencies were investigated in the Sindhi and compared with Marathi, Gujarati and North Indian population from Mumbai. This work is a part of a larger effort aimed at analysis of the HLA profile of diverse Indian ethnics to establish an umbilical cord stem cell panel in India. HLA polymorphisms at the HLA‐A, B and DRB1 loci were determined in 413 cord blood samples by the molecular method of polymerase chain reaction using sequence‐specific primer amplification. The most frequent alleles included A*01, A*02, A*11 and A*24 at A locus, B*35 and B*40 at B locus and DRB1*07 and DRB1*15 in all the four groups, although the frequency fluctuated in individual communities. HLA‐DRB1*03 was significantly high (P < 0.05) in the Sindhi. Phylogenetic association using neighbour‐joining tree, based on DA genetic distances for HLA‐A and HLA‐B alleles, indicated that the Sindhis cluster with North Indian and Pakistan Sindhi. The three locus haplotype analysis revealed that A*02‐B*40‐DRB1*15 and A*33‐B*44‐DRB1*07 were common haplotypes in all the groups. The three locus haplotypes found suggest an influence from Caucasian and Oriental populations. The data will be useful in developing an umbilical cord stem cell panel in India. The results will have clinical implications in unrelated umbilical cord stem cell for transplantation in India.</description><subject>Cord blood</subject><subject>Data processing</subject><subject>Dopamine</subject><subject>Drb1 protein</subject><subject>Ethnic groups</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic distance</subject><subject>Haplotypes</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>India - ethnology</subject><subject>Language</subject><subject>Phylogeny</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic</subject><subject>Population genetics</subject><subject>Primers</subject><subject>Stem cells</subject><subject>Umbilical cord</subject><issn>1744-3121</issn><issn>1744-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1PwjAUhhujEUX_gtmdN262a9duiTeEKIyARl0Cd03XlVDclyuL7N-7OeRWz805OX3e0-QBwELQQW3dbx3ECLExwivHhe0WwgBTZ38CLo4Pp8fZRQNwacwWQkwJgedg4EIP-T6hF4BO5yOrLNImK6pyo01mLJ1b7zpPNtqSRZbVud413W5RZ7HQd1aYJ1pcgbO1SI26PvQhiJ4eo_HUnr9MwvFobkuCGbWJFIx5SPqCCUE8hl1KmBIeUwH0XSWkhLGbSC9BBMOEiiBWmEAhJPYRCQgegtv-bFkVn7UyO55pI1WailwVteE-hdj3WgF_ky5CQUCJ15J-T8qqMKZSa15WOhNVwxHknV2-5Z043knknV3-Y5fv2-jN4ZM6zlRyDP7qbIGHHvjSqWr-fZiHs7Ad2rjdx7XZqf0xLqoPThlmHl8-T3g0e40Wq-Ubn-JvXZiWAw</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Chhaya, S.</creator><creator>Desai, S.</creator><creator>Saranath, D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201010</creationdate><title>HLA polymorphisms in Sindhi community in Mumbai, India</title><author>Chhaya, S. ; Desai, S. ; Saranath, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4376-4ca7751c8a7aa45732647ea57e9082eacc0b2dc5d1430d6a9be340aac3814943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Cord blood</topic><topic>Data processing</topic><topic>Dopamine</topic><topic>Drb1 protein</topic><topic>Ethnic groups</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic distance</topic><topic>Haplotypes</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>HLA Antigens - genetics</topic><topic>Humans</topic><topic>India - ethnology</topic><topic>Language</topic><topic>Phylogeny</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Genetic</topic><topic>Population genetics</topic><topic>Primers</topic><topic>Stem cells</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chhaya, S.</creatorcontrib><creatorcontrib>Desai, S.</creatorcontrib><creatorcontrib>Saranath, D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>International journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chhaya, S.</au><au>Desai, S.</au><au>Saranath, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA polymorphisms in Sindhi community in Mumbai, India</atitle><jtitle>International journal of immunogenetics</jtitle><addtitle>Int J Immunogenet</addtitle><date>2010-10</date><risdate>2010</risdate><volume>37</volume><issue>5</issue><spage>373</spage><epage>377</epage><pages>373-377</pages><issn>1744-3121</issn><eissn>1744-313X</eissn><abstract>Summary
Indian population is an amalgamation of various ethnicities, cultural and linguistic diversities, primarily due to marriages within a community. HLA‐A, B and DRB1 alleles and haplotype frequencies were investigated in the Sindhi and compared with Marathi, Gujarati and North Indian population from Mumbai. This work is a part of a larger effort aimed at analysis of the HLA profile of diverse Indian ethnics to establish an umbilical cord stem cell panel in India. HLA polymorphisms at the HLA‐A, B and DRB1 loci were determined in 413 cord blood samples by the molecular method of polymerase chain reaction using sequence‐specific primer amplification. The most frequent alleles included A*01, A*02, A*11 and A*24 at A locus, B*35 and B*40 at B locus and DRB1*07 and DRB1*15 in all the four groups, although the frequency fluctuated in individual communities. HLA‐DRB1*03 was significantly high (P < 0.05) in the Sindhi. Phylogenetic association using neighbour‐joining tree, based on DA genetic distances for HLA‐A and HLA‐B alleles, indicated that the Sindhis cluster with North Indian and Pakistan Sindhi. The three locus haplotype analysis revealed that A*02‐B*40‐DRB1*15 and A*33‐B*44‐DRB1*07 were common haplotypes in all the groups. The three locus haplotypes found suggest an influence from Caucasian and Oriental populations. The data will be useful in developing an umbilical cord stem cell panel in India. The results will have clinical implications in unrelated umbilical cord stem cell for transplantation in India.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20518846</pmid><doi>10.1111/j.1744-313X.2010.00936.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Cord blood Data processing Dopamine Drb1 protein Ethnic groups Female Gene Frequency Genetic distance Haplotypes Histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics HLA Antigens - genetics Humans India - ethnology Language Phylogeny Polymerase chain reaction Polymorphism, Genetic Population genetics Primers Stem cells Umbilical cord |
| title | HLA polymorphisms in Sindhi community in Mumbai, India |
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