Free radical peroxidation products in cerebrospinal fluid and serum of patients with multiple sclerosis after glucocorticoid therapy
Multiple sclerosis (MS) patients were found to have elevated thiobarbituric acid reactive material levels, increased soluble sulfhydryl groups and reduced protein sulfhydryl groups in cerebrospinal fluid and serum, and slightly reduced superoxide dismutase in serum, which suggested disease activatin...
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| Veröffentlicht in: | Folia neuropathologica 2010, Vol.48 (2), p.116-122 |
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| container_title | Folia neuropathologica |
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| creator | Mitosek-Szewczyk, Krystyna Gordon-Krajcer, Wanda Walendzik, Piotr Stelmasiak, Zbigniew |
| description | Multiple sclerosis (MS) patients were found to have elevated thiobarbituric acid reactive material levels, increased soluble sulfhydryl groups and reduced protein sulfhydryl groups in cerebrospinal fluid and serum, and slightly reduced superoxide dismutase in serum, which suggested disease activating free radical peroxidation. Moreover, levels of these varied across methylprednisolone (MP) therapy. We observed significant differences in the levels of peroxidation products between MS patients and controls. These changes were most evident in relapse. After MP therapy, levels of these indicators approached control values, especially in the remission period. Our findings suggest that MP protects against free radical attack. |
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Moreover, levels of these varied across methylprednisolone (MP) therapy. We observed significant differences in the levels of peroxidation products between MS patients and controls. These changes were most evident in relapse. After MP therapy, levels of these indicators approached control values, especially in the remission period. Our findings suggest that MP protects against free radical attack.</description><identifier>ISSN: 1641-4640</identifier><identifier>EISSN: 1509-572X</identifier><identifier>PMID: 20602292</identifier><language>eng</language><publisher>Poland</publisher><subject>Adult ; Female ; Free Radicals - blood ; Free Radicals - cerebrospinal fluid ; Glucocorticoids - therapeutic use ; Humans ; Lipid Peroxidation - drug effects ; Lipid Peroxidation - physiology ; Male ; Methylprednisolone - therapeutic use ; Multiple Sclerosis - blood ; Multiple Sclerosis - cerebrospinal fluid ; Multiple Sclerosis - drug therapy ; Sulfhydryl Compounds - analysis ; Sulfhydryl Compounds - blood ; Sulfhydryl Compounds - cerebrospinal fluid ; Superoxide Dismutase - analysis ; Superoxide Dismutase - metabolism ; Superoxide Dismutase-1 ; Thiobarbituric Acid Reactive Substances - analysis ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Folia neuropathologica, 2010, Vol.48 (2), p.116-122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20602292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitosek-Szewczyk, Krystyna</creatorcontrib><creatorcontrib>Gordon-Krajcer, Wanda</creatorcontrib><creatorcontrib>Walendzik, Piotr</creatorcontrib><creatorcontrib>Stelmasiak, Zbigniew</creatorcontrib><title>Free radical peroxidation products in cerebrospinal fluid and serum of patients with multiple sclerosis after glucocorticoid therapy</title><title>Folia neuropathologica</title><addtitle>Folia Neuropathol</addtitle><description>Multiple sclerosis (MS) patients were found to have elevated thiobarbituric acid reactive material levels, increased soluble sulfhydryl groups and reduced protein sulfhydryl groups in cerebrospinal fluid and serum, and slightly reduced superoxide dismutase in serum, which suggested disease activating free radical peroxidation. Moreover, levels of these varied across methylprednisolone (MP) therapy. We observed significant differences in the levels of peroxidation products between MS patients and controls. These changes were most evident in relapse. After MP therapy, levels of these indicators approached control values, especially in the remission period. Our findings suggest that MP protects against free radical attack.</description><subject>Adult</subject><subject>Female</subject><subject>Free Radicals - blood</subject><subject>Free Radicals - cerebrospinal fluid</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipid Peroxidation - physiology</subject><subject>Male</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Multiple Sclerosis - blood</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple Sclerosis - drug therapy</subject><subject>Sulfhydryl Compounds - analysis</subject><subject>Sulfhydryl Compounds - blood</subject><subject>Sulfhydryl Compounds - cerebrospinal fluid</subject><subject>Superoxide Dismutase - analysis</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Superoxide Dismutase-1</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>1641-4640</issn><issn>1509-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLxDAUhYsozjj6FyQ7V4U0SdNmKYOjwoAbBXclj1snkjY1D3T2_nAD6urcxXc_OOekWjctFnXbkdfTcnPW1IwzvKouYnzHmLVMkPNqRTDHhAiyrr53AQAFaayWDi0Q_Jc1Mlk_oyV4k3WKyM5IQwAVfFzsXLDRZWuQnA2KEPKE_IiW8gNzgT9tOqApu2QXByhqV5TRRiTHBAG9uay99iFZ7YsiHSDI5XhZnY3SRbj6y031srt73j7U-6f7x-3tvl5Ig1OtSSe06Aj0QneYcaqUFKQdCaNA214prkp73jFBhZKm17oxFMxIGdcUhKKb6ubXW6p9ZIhpmGzU4Jycwec49BzTnnYMF_L6j8xqAjMswU4yHIf_4egPQP5umg</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Mitosek-Szewczyk, Krystyna</creator><creator>Gordon-Krajcer, Wanda</creator><creator>Walendzik, Piotr</creator><creator>Stelmasiak, Zbigniew</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope></search><sort><creationdate>2010</creationdate><title>Free radical peroxidation products in cerebrospinal fluid and serum of patients with multiple sclerosis after glucocorticoid therapy</title><author>Mitosek-Szewczyk, Krystyna ; 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Moreover, levels of these varied across methylprednisolone (MP) therapy. We observed significant differences in the levels of peroxidation products between MS patients and controls. These changes were most evident in relapse. After MP therapy, levels of these indicators approached control values, especially in the remission period. Our findings suggest that MP protects against free radical attack.</abstract><cop>Poland</cop><pmid>20602292</pmid><tpages>7</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Female Free Radicals - blood Free Radicals - cerebrospinal fluid Glucocorticoids - therapeutic use Humans Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Male Methylprednisolone - therapeutic use Multiple Sclerosis - blood Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - drug therapy Sulfhydryl Compounds - analysis Sulfhydryl Compounds - blood Sulfhydryl Compounds - cerebrospinal fluid Superoxide Dismutase - analysis Superoxide Dismutase - metabolism Superoxide Dismutase-1 Thiobarbituric Acid Reactive Substances - analysis Thiobarbituric Acid Reactive Substances - metabolism |
| title | Free radical peroxidation products in cerebrospinal fluid and serum of patients with multiple sclerosis after glucocorticoid therapy |
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