Glycoconjugates in the mammalian auditory system
J. Neurochem. (2011) 116, 756–763. Cell‐surface glycoconjugates, such as proteoglycans, glycoproteins, and glycosphingolipids have been suggested to serve important functions in hearing because of their variety and their specific expression patterns during the development and maturation of cochlea....
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| Veröffentlicht in: | Journal of neurochemistry 2011-03, Vol.116 (5), p.756-763 |
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| container_title | Journal of neurochemistry |
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| creator | Go, Shinji Yoshikawa, Misato Inokuchi, Jin‐ichi |
| description | J. Neurochem. (2011) 116, 756–763.
Cell‐surface glycoconjugates, such as proteoglycans, glycoproteins, and glycosphingolipids have been suggested to serve important functions in hearing because of their variety and their specific expression patterns during the development and maturation of cochlea. However, there has been no definitive proof regarding their involvement in auditory functions. In this study, we provide an overview of the expression of glycoconjugates in auditory systems and consider their possible involvement in hearing functions. We include our recent findings regarding deafness in ganglioside (sialic acid containing glycosphingolipids)‐deficient mice, and address the importance of functional glycobiology in auditory systems. |
| doi_str_mv | 10.1111/j.1471-4159.2010.07099.x |
| format | Article |
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Cell‐surface glycoconjugates, such as proteoglycans, glycoproteins, and glycosphingolipids have been suggested to serve important functions in hearing because of their variety and their specific expression patterns during the development and maturation of cochlea. However, there has been no definitive proof regarding their involvement in auditory functions. In this study, we provide an overview of the expression of glycoconjugates in auditory systems and consider their possible involvement in hearing functions. We include our recent findings regarding deafness in ganglioside (sialic acid containing glycosphingolipids)‐deficient mice, and address the importance of functional glycobiology in auditory systems.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.2010.07099.x</identifier><identifier>PMID: 21214575</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Auditory Pathways - metabolism ; Auditory Pathways - ultrastructure ; Auditory system ; Cochlea ; Cochlea - metabolism ; Cochlea - ultrastructure ; Deafness ; Ears & hearing ; Eliminative Behavior, Animal ; Gangliosides ; glycoconjugates ; Glycoconjugates - metabolism ; Glycoproteins ; Glycosphingolipids ; Hearing loss ; Hearing Loss - metabolism ; Humans ; Mammals ; Membrane Microdomains - physiology ; Models, Biological ; Neurochemistry ; Polysaccharides - metabolism ; Proteoglycans ; Reviews ; Sialic acids</subject><ispartof>Journal of neurochemistry, 2011-03, Vol.116 (5), p.756-763</ispartof><rights>2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry</rights><rights>2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5439-e7bc80128cceaee2ef6d599a20fa44a1ffdd7f07de2068b176571fbd5a1656f43</citedby><cites>FETCH-LOGICAL-c5439-e7bc80128cceaee2ef6d599a20fa44a1ffdd7f07de2068b176571fbd5a1656f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.2010.07099.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.2010.07099.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21214575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Go, Shinji</creatorcontrib><creatorcontrib>Yoshikawa, Misato</creatorcontrib><creatorcontrib>Inokuchi, Jin‐ichi</creatorcontrib><title>Glycoconjugates in the mammalian auditory system</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>J. Neurochem. (2011) 116, 756–763.
Cell‐surface glycoconjugates, such as proteoglycans, glycoproteins, and glycosphingolipids have been suggested to serve important functions in hearing because of their variety and their specific expression patterns during the development and maturation of cochlea. However, there has been no definitive proof regarding their involvement in auditory functions. In this study, we provide an overview of the expression of glycoconjugates in auditory systems and consider their possible involvement in hearing functions. We include our recent findings regarding deafness in ganglioside (sialic acid containing glycosphingolipids)‐deficient mice, and address the importance of functional glycobiology in auditory systems.</description><subject>Animals</subject><subject>Auditory Pathways - metabolism</subject><subject>Auditory Pathways - ultrastructure</subject><subject>Auditory system</subject><subject>Cochlea</subject><subject>Cochlea - metabolism</subject><subject>Cochlea - ultrastructure</subject><subject>Deafness</subject><subject>Ears & hearing</subject><subject>Eliminative Behavior, Animal</subject><subject>Gangliosides</subject><subject>glycoconjugates</subject><subject>Glycoconjugates - metabolism</subject><subject>Glycoproteins</subject><subject>Glycosphingolipids</subject><subject>Hearing loss</subject><subject>Hearing Loss - metabolism</subject><subject>Humans</subject><subject>Mammals</subject><subject>Membrane Microdomains - physiology</subject><subject>Models, Biological</subject><subject>Neurochemistry</subject><subject>Polysaccharides - metabolism</subject><subject>Proteoglycans</subject><subject>Reviews</subject><subject>Sialic acids</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkLtOwzAUhi0EoqXwCihiYUo5x_ElGRhQxVUVLDBbbmJDolxKnAjy9ji0dGABL7bO-f5f8kdIgDBHfy6KOTKJIUOezCn4KUhIkvnnHpnuFvtkCkBpGAGjE3LkXAGAggk8JBOKFBmXfErgthzSJm3qon_VnXFBXgfdmwkqXVW6zHUd6D7Lu6YdAje4zlTH5MDq0pmT7T0jLzfXz4u7cPl0e7-4WoYpZ1ESGrlKY0Aap6nRxlBjRcaTRFOwmjGN1maZtCAzQ0HEK5SCS7SrjGsUXFgWzcj5pnfdNu-9cZ2qcpeastS1aXqnYgFRHAmUf5PcO-GxEJ48-0UWTd_W_hseAhZJjLiH4g2Uto1zrbFq3eaVbgeFoEb7qlCjZDVKVqN99W1fffro6ba_X1Um2wV_dHvgcgN85KUZ_l2sHh4X4yv6AudDkfQ</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Go, Shinji</creator><creator>Yoshikawa, Misato</creator><creator>Inokuchi, Jin‐ichi</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Glycoconjugates in the mammalian auditory system</title><author>Go, Shinji ; 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Neurochem. (2011) 116, 756–763.
Cell‐surface glycoconjugates, such as proteoglycans, glycoproteins, and glycosphingolipids have been suggested to serve important functions in hearing because of their variety and their specific expression patterns during the development and maturation of cochlea. However, there has been no definitive proof regarding their involvement in auditory functions. In this study, we provide an overview of the expression of glycoconjugates in auditory systems and consider their possible involvement in hearing functions. We include our recent findings regarding deafness in ganglioside (sialic acid containing glycosphingolipids)‐deficient mice, and address the importance of functional glycobiology in auditory systems.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21214575</pmid><doi>10.1111/j.1471-4159.2010.07099.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Auditory Pathways - metabolism Auditory Pathways - ultrastructure Auditory system Cochlea Cochlea - metabolism Cochlea - ultrastructure Deafness Ears & hearing Eliminative Behavior, Animal Gangliosides glycoconjugates Glycoconjugates - metabolism Glycoproteins Glycosphingolipids Hearing loss Hearing Loss - metabolism Humans Mammals Membrane Microdomains - physiology Models, Biological Neurochemistry Polysaccharides - metabolism Proteoglycans Reviews Sialic acids |
| title | Glycoconjugates in the mammalian auditory system |
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