Validation of in vitro screening models for progestagenic activities: Inter-assay comparison and correlation with in vivo activity in rabbits

The PR CALUX® cell line is a stably transfected human U2-OS cell line expressing the human PR and a luciferase reporter construct containing three progesterone-responsive elements coupled to a minimal promoter. The validity of this assay has been studied as an alternative to the McPhail assay in rab...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology in vitro 2011-03, Vol.25 (2), p.545-554
Hauptverfasser:	Sonneveld, Edwin, Pieterse, Bart, Schoonen, Willem G., van der Burg, Bart
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay - methods Cell Line CHO Cells Cricetinae Cricetulus Female Humans McPhail assay Nuclear receptors Progesterone Progesterone - pharmacology Progesterone receptor Rabbits Receptors, Progesterone - physiology Reporter gene assay Screening model Validation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!