Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells

► Loganin rescued neuronal cells against H 2O 2-induced apoptosis. ► Neuroprotective effects of loganin may be related to its anti-oxidative effects. ► Loganin can potentially be used in the design and development of drugs to prevent oxidative stress-mediated neurodegenerative diseases. We investiga...

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Veröffentlicht in:	Neurochemistry international 2011-03, Vol.58 (4), p.533-541
Hauptverfasser:	Kwon, Seung-Hwan, Kim, Ji-Ah, Hong, Sa-Ik, Jung, Yang-Hee, Kim, Hyoung-Chun, Lee, Seok-Yong, Jang, Choon-Gon
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Biological and medical sciences Blotting, Western Caspase 3 - metabolism Cell Line, Tumor Cytochromes c - metabolism Fundamental and applied biological sciences. Psychology H 2O 2 Humans Hydrogen Peroxide - antagonists & inhibitors Hydrogen Peroxide - pharmacology Iridoids - pharmacology L-Lactate Dehydrogenase - metabolism Loganin Membrane Potentials - drug effects Mitogen-activated protein kinase Neuroblastoma - enzymology Neuroblastoma - metabolism Neuroblastoma - pathology Neurodegenerative disease Oxidative stress Phosphorylation - drug effects Poly(ADP-ribose) Polymerases - metabolism Protein Kinases - metabolism Reactive Oxygen Species - metabolism Vertebrates: nervous system and sense organs
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