Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells
► Loganin rescued neuronal cells against H 2O 2-induced apoptosis. ► Neuroprotective effects of loganin may be related to its anti-oxidative effects. ► Loganin can potentially be used in the design and development of drugs to prevent oxidative stress-mediated neurodegenerative diseases. We investiga...
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| Veröffentlicht in: | Neurochemistry international 2011-03, Vol.58 (4), p.533-541 |
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| creator | Kwon, Seung-Hwan Kim, Ji-Ah Hong, Sa-Ik Jung, Yang-Hee Kim, Hyoung-Chun Lee, Seok-Yong Jang, Choon-Gon |
| description | ► Loganin rescued neuronal cells against H
2O
2-induced apoptosis. ► Neuroprotective effects of loganin may be related to its anti-oxidative effects. ► Loganin can potentially be used in the design and development of drugs to prevent oxidative stress-mediated neurodegenerative diseases.
We investigated the mechanisms underlying the protective effects of loganin against hydrogen peroxide (H
2O
2)-induced neuronal toxicity in SH-SY5Y cells. The neuroprotective effect of loganin was investigated by treating SH-SY5Y cells with H
2O
2 and then measuring the reduction in H
2O
2-induced apoptosis using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays. Following H
2O
2 exposure, Hoechst 33258 staining indicated nuclear condensation in a large proportion of SH-SY5Y cells, along with an increase in reactive oxygen species (ROS) production and an intracellular decrease in mitochondria membrane potential (MMP). Loganin was effective in attenuating all the above-stated phenotypes induced by H
2O
2. Pretreatment with loganin significantly increased cell viability, reduced H
2O
2-induced LDH release and ROS production, and effectively increased intracellular MMP. Pretreatment with loganin also significantly decreased the nuclear condensation induced by H
2O
2. Western blot data revealed that loganin inhibited the H
2O
2-induced up-regulation of cleaved poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3, increased the H
2O
2-induced decrease in the Bcl-2/Bax ratio, and attenuated the H
2O
2-induced release of cytochrome
c from mitochondria to the cytosol. Furthermore, pretreatment with loganin significantly attenuated the H
2O
2-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 (ERK 1/2). These results suggest that the protective effects of loganin against H
2O
2-induced apoptosis may be due to a decrease in the Bcl-2/Bax ratio expression due to the inhibition of the phosphorylation of JNK, p38, and ERK 1/2 MAPKs. Loganin's neuroprotective properties indicate that this compound may be a potential therapeutic agent for the treatment of neurodegenerative diseases. |
| doi_str_mv | 10.1016/j.neuint.2011.01.012 |
| format | Article |
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2O
2-induced apoptosis. ► Neuroprotective effects of loganin may be related to its anti-oxidative effects. ► Loganin can potentially be used in the design and development of drugs to prevent oxidative stress-mediated neurodegenerative diseases.
We investigated the mechanisms underlying the protective effects of loganin against hydrogen peroxide (H
2O
2)-induced neuronal toxicity in SH-SY5Y cells. The neuroprotective effect of loganin was investigated by treating SH-SY5Y cells with H
2O
2 and then measuring the reduction in H
2O
2-induced apoptosis using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays. Following H
2O
2 exposure, Hoechst 33258 staining indicated nuclear condensation in a large proportion of SH-SY5Y cells, along with an increase in reactive oxygen species (ROS) production and an intracellular decrease in mitochondria membrane potential (MMP). Loganin was effective in attenuating all the above-stated phenotypes induced by H
2O
2. Pretreatment with loganin significantly increased cell viability, reduced H
2O
2-induced LDH release and ROS production, and effectively increased intracellular MMP. Pretreatment with loganin also significantly decreased the nuclear condensation induced by H
2O
2. Western blot data revealed that loganin inhibited the H
2O
2-induced up-regulation of cleaved poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3, increased the H
2O
2-induced decrease in the Bcl-2/Bax ratio, and attenuated the H
2O
2-induced release of cytochrome
c from mitochondria to the cytosol. Furthermore, pretreatment with loganin significantly attenuated the H
2O
2-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 (ERK 1/2). These results suggest that the protective effects of loganin against H
2O
2-induced apoptosis may be due to a decrease in the Bcl-2/Bax ratio expression due to the inhibition of the phosphorylation of JNK, p38, and ERK 1/2 MAPKs. Loganin's neuroprotective properties indicate that this compound may be a potential therapeutic agent for the treatment of neurodegenerative diseases.</description><identifier>ISSN: 0197-0186</identifier><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/j.neuint.2011.01.012</identifier><identifier>PMID: 21241762</identifier><identifier>CODEN: NEUIDS</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Apoptosis ; Apoptosis - drug effects ; Biological and medical sciences ; Blotting, Western ; Caspase 3 - metabolism ; Cell Line, Tumor ; Cytochromes c - metabolism ; Fundamental and applied biological sciences. Psychology ; H 2O 2 ; Humans ; Hydrogen Peroxide - antagonists & inhibitors ; Hydrogen Peroxide - pharmacology ; Iridoids - pharmacology ; L-Lactate Dehydrogenase - metabolism ; Loganin ; Membrane Potentials - drug effects ; Mitogen-activated protein kinase ; Neuroblastoma - enzymology ; Neuroblastoma - metabolism ; Neuroblastoma - pathology ; Neurodegenerative disease ; Oxidative stress ; Phosphorylation - drug effects ; Poly(ADP-ribose) Polymerases - metabolism ; Protein Kinases - metabolism ; Reactive Oxygen Species - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurochemistry international, 2011-03, Vol.58 (4), p.533-541</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-7e1f1e7e992af369fa74b01585ae0d668d595a6f4404761eb0c55c9aea67683</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197018611000143$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23924010$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21241762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Seung-Hwan</creatorcontrib><creatorcontrib>Kim, Ji-Ah</creatorcontrib><creatorcontrib>Hong, Sa-Ik</creatorcontrib><creatorcontrib>Jung, Yang-Hee</creatorcontrib><creatorcontrib>Kim, Hyoung-Chun</creatorcontrib><creatorcontrib>Lee, Seok-Yong</creatorcontrib><creatorcontrib>Jang, Choon-Gon</creatorcontrib><title>Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>► Loganin rescued neuronal cells against H
2O
2-induced apoptosis. ► Neuroprotective effects of loganin may be related to its anti-oxidative effects. ► Loganin can potentially be used in the design and development of drugs to prevent oxidative stress-mediated neurodegenerative diseases.
We investigated the mechanisms underlying the protective effects of loganin against hydrogen peroxide (H
2O
2)-induced neuronal toxicity in SH-SY5Y cells. The neuroprotective effect of loganin was investigated by treating SH-SY5Y cells with H
2O
2 and then measuring the reduction in H
2O
2-induced apoptosis using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays. Following H
2O
2 exposure, Hoechst 33258 staining indicated nuclear condensation in a large proportion of SH-SY5Y cells, along with an increase in reactive oxygen species (ROS) production and an intracellular decrease in mitochondria membrane potential (MMP). Loganin was effective in attenuating all the above-stated phenotypes induced by H
2O
2. Pretreatment with loganin significantly increased cell viability, reduced H
2O
2-induced LDH release and ROS production, and effectively increased intracellular MMP. Pretreatment with loganin also significantly decreased the nuclear condensation induced by H
2O
2. Western blot data revealed that loganin inhibited the H
2O
2-induced up-regulation of cleaved poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3, increased the H
2O
2-induced decrease in the Bcl-2/Bax ratio, and attenuated the H
2O
2-induced release of cytochrome
c from mitochondria to the cytosol. Furthermore, pretreatment with loganin significantly attenuated the H
2O
2-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 (ERK 1/2). These results suggest that the protective effects of loganin against H
2O
2-induced apoptosis may be due to a decrease in the Bcl-2/Bax ratio expression due to the inhibition of the phosphorylation of JNK, p38, and ERK 1/2 MAPKs. Loganin's neuroprotective properties indicate that this compound may be a potential therapeutic agent for the treatment of neurodegenerative diseases.</description><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Caspase 3 - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cytochromes c - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>H 2O 2</subject><subject>Humans</subject><subject>Hydrogen Peroxide - antagonists & inhibitors</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Iridoids - pharmacology</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Loganin</subject><subject>Membrane Potentials - drug effects</subject><subject>Mitogen-activated protein kinase</subject><subject>Neuroblastoma - enzymology</subject><subject>Neuroblastoma - metabolism</subject><subject>Neuroblastoma - pathology</subject><subject>Neurodegenerative disease</subject><subject>Oxidative stress</subject><subject>Phosphorylation - drug effects</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Protein Kinases - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-OEyEUh4nRuHX1DYzhxniz0wVmgOHGZLNZd7X1T6w3e0Uoc6almcIszJjtK_jUMmnVO5NDuOD7ceB8CL2mZE4JFZe7uYfR-WHOCKVzMhV7gma0lqxQkldP0YxQJQtCa3GGXqS0I4RIRfhzdMYoq6gUbIZ-LcPGeOdxH8MAdkjYbIzzacDbQxPDBvIJxPDoGiicb0YLDTZ96IeQXMLrA3Z-69ZucH6D-21IecVDZwYXPA4t_vRlcYH7sr7Axjf45vsC00uGP199W6ScxKu7YnXP77GFrksv0bPWdAlenfZztPpw8-P6rlh-vf14fbUsbFWroZBAWwoSlGKmLYVqjazWhPKaGyCNEHXDFTeirSpSSUFhTSznVhkwQoq6PEfvjrfmDz-MkAa9d2nqbzyEMelakLKmXNJMVkfSxpBShFb30e1NPGhK9KRA7_RRgZ4UaDIVy7E3pwbjeg_N39CfmWfg7QkwyZqujcZbl_5xpWIVoSRz748c5GH8dBB1sg58NuBiNqWb4P7_kt96ZKXz</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Kwon, Seung-Hwan</creator><creator>Kim, Ji-Ah</creator><creator>Hong, Sa-Ik</creator><creator>Jung, Yang-Hee</creator><creator>Kim, Hyoung-Chun</creator><creator>Lee, Seok-Yong</creator><creator>Jang, Choon-Gon</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20110301</creationdate><title>Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells</title><author>Kwon, Seung-Hwan ; Kim, Ji-Ah ; Hong, Sa-Ik ; Jung, Yang-Hee ; Kim, Hyoung-Chun ; Lee, Seok-Yong ; Jang, Choon-Gon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-7e1f1e7e992af369fa74b01585ae0d668d595a6f4404761eb0c55c9aea67683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Caspase 3 - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cytochromes c - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>H 2O 2</topic><topic>Humans</topic><topic>Hydrogen Peroxide - antagonists & inhibitors</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Iridoids - pharmacology</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Loganin</topic><topic>Membrane Potentials - drug effects</topic><topic>Mitogen-activated protein kinase</topic><topic>Neuroblastoma - enzymology</topic><topic>Neuroblastoma - metabolism</topic><topic>Neuroblastoma - pathology</topic><topic>Neurodegenerative disease</topic><topic>Oxidative stress</topic><topic>Phosphorylation - drug effects</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Protein Kinases - metabolism</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Seung-Hwan</creatorcontrib><creatorcontrib>Kim, Ji-Ah</creatorcontrib><creatorcontrib>Hong, Sa-Ik</creatorcontrib><creatorcontrib>Jung, Yang-Hee</creatorcontrib><creatorcontrib>Kim, Hyoung-Chun</creatorcontrib><creatorcontrib>Lee, Seok-Yong</creatorcontrib><creatorcontrib>Jang, Choon-Gon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Seung-Hwan</au><au>Kim, Ji-Ah</au><au>Hong, Sa-Ik</au><au>Jung, Yang-Hee</au><au>Kim, Hyoung-Chun</au><au>Lee, Seok-Yong</au><au>Jang, Choon-Gon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>58</volume><issue>4</issue><spage>533</spage><epage>541</epage><pages>533-541</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><coden>NEUIDS</coden><abstract>► Loganin rescued neuronal cells against H
2O
2-induced apoptosis. ► Neuroprotective effects of loganin may be related to its anti-oxidative effects. ► Loganin can potentially be used in the design and development of drugs to prevent oxidative stress-mediated neurodegenerative diseases.
We investigated the mechanisms underlying the protective effects of loganin against hydrogen peroxide (H
2O
2)-induced neuronal toxicity in SH-SY5Y cells. The neuroprotective effect of loganin was investigated by treating SH-SY5Y cells with H
2O
2 and then measuring the reduction in H
2O
2-induced apoptosis using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays. Following H
2O
2 exposure, Hoechst 33258 staining indicated nuclear condensation in a large proportion of SH-SY5Y cells, along with an increase in reactive oxygen species (ROS) production and an intracellular decrease in mitochondria membrane potential (MMP). Loganin was effective in attenuating all the above-stated phenotypes induced by H
2O
2. Pretreatment with loganin significantly increased cell viability, reduced H
2O
2-induced LDH release and ROS production, and effectively increased intracellular MMP. Pretreatment with loganin also significantly decreased the nuclear condensation induced by H
2O
2. Western blot data revealed that loganin inhibited the H
2O
2-induced up-regulation of cleaved poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3, increased the H
2O
2-induced decrease in the Bcl-2/Bax ratio, and attenuated the H
2O
2-induced release of cytochrome
c from mitochondria to the cytosol. Furthermore, pretreatment with loganin significantly attenuated the H
2O
2-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 (ERK 1/2). These results suggest that the protective effects of loganin against H
2O
2-induced apoptosis may be due to a decrease in the Bcl-2/Bax ratio expression due to the inhibition of the phosphorylation of JNK, p38, and ERK 1/2 MAPKs. Loganin's neuroprotective properties indicate that this compound may be a potential therapeutic agent for the treatment of neurodegenerative diseases.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21241762</pmid><doi>10.1016/j.neuint.2011.01.012</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-0186 |
| ispartof | Neurochemistry international, 2011-03, Vol.58 (4), p.533-541 |
| issn | 0197-0186 1872-9754 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Apoptosis Apoptosis - drug effects Biological and medical sciences Blotting, Western Caspase 3 - metabolism Cell Line, Tumor Cytochromes c - metabolism Fundamental and applied biological sciences. Psychology H 2O 2 Humans Hydrogen Peroxide - antagonists & inhibitors Hydrogen Peroxide - pharmacology Iridoids - pharmacology L-Lactate Dehydrogenase - metabolism Loganin Membrane Potentials - drug effects Mitogen-activated protein kinase Neuroblastoma - enzymology Neuroblastoma - metabolism Neuroblastoma - pathology Neurodegenerative disease Oxidative stress Phosphorylation - drug effects Poly(ADP-ribose) Polymerases - metabolism Protein Kinases - metabolism Reactive Oxygen Species - metabolism Vertebrates: nervous system and sense organs |
| title | Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells |
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