Regulation of somatostatin gene expression by brain derived neurotrophic factor in fetal rat cerebrocortical cells

Abstract Brain derived neurotrophic factor (BDNF) increases the levels of somatostatin (SS) and its mRNA. To test the hypothesis that the regulation of SS synthesis by BDNF occurs at the transcriptional level and requires specific promoter sequences, cerebrocortical and PC12trkB neurons were transie...

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Veröffentlicht in:	Brain research 2011-02, Vol.1375, p.28-40
Hauptverfasser:	Sánchez-Muñoz, Isabel, Sánchez-Franco, Franco, Vallejo, Mario, Fernández, Antonio, Palacios, Nuria, Fernández, Miriam, Sánchez-Grande, María, Cacicedo, Lucinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibodies BDNF Biological and medical sciences Blotting, Western brain Brain-Derived Neurotrophic Factor - antagonists & inhibitors Brain-Derived Neurotrophic Factor - pharmacology Cell physiology Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - metabolism CREB-CRE Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Electric Stimulation Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Immunoglobulin G - isolation & purification luciferase Mitogen-Activated Protein Kinases - antagonists & inhibitors Molecular and cellular biology Neurology neurons phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - antagonists & inhibitors Potassium - pharmacology Pregnancy promoter regions Rats Rats, Sprague-Dawley Regulatory Elements, Transcriptional reporter genes Responses to growth factors, tumor promotors, other factors RNA, Messenger - biosynthesis RNA, Messenger - genetics signal transduction Signal Transduction - drug effects Signaling pathway somatostatin Somatostatin - biosynthesis Somatostatin - genetics transcription (genetics) Transcription, Genetic - drug effects Transfection
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