Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics

In N1E-115 cells, neurite retraction induced by neurite remodelling factors such as lysophosphatidic acid, sphingosine 1-phosphate and semaphorin 3A require the activity of phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks). PIP5Ks synthesise the phosphoinositide lipid second messenger phosphatidyl...

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Veröffentlicht in:	Journal of cell science 2010-10, Vol.123 (20), p.3535-3546
Hauptverfasser:	Halstead, Jonathan R, Savaskan, Nicolai E, van den Bout, Iman, Van Horck, Francis, Hajdo-Milasinovic, Amra, Snell, Mireille, Keune, Willem-Jan, ten Klooster, Jean-Paul, Hordijk, Peter L, Divecha, Nullin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cells, Cultured Immunoblotting Immunoprecipitation Mice Microscopy, Confocal Neurites - metabolism Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Vinculin - metabolism
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