TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients
Summary The aim of this study was to evaluate the frequency of TNFa–e microsatellites and the promoter region (TNF‐308 and TNF‐238) in HIV/AIDS‐infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case–control association study. Microsatellite and the TNF promot...
Gespeichert in:
| Veröffentlicht in: | International journal of immunogenetics 2010-10, Vol.37 (5), p.379-385 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 385 |
|---|---|
| container_issue | 5 |
| container_start_page | 379 |
| container_title | International journal of immunogenetics |
| container_volume | 37 |
| creator | Silva, M. M. Simões, R. T. Castelli, E. C. Mendes-Junior, C. T. Deghaide, N. H. S. Tsuda, L. C. Machado, A. A. Donadi, E. A. Fernandes, A. P. M. |
| description | Summary
The aim of this study was to evaluate the frequency of TNFa–e microsatellites and the promoter region (TNF‐308 and TNF‐238) in HIV/AIDS‐infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case–control association study. Microsatellite and the TNF promoter region polymorphisms were amplified by PCR and submitted to polyacrylamide gel electrophoresis. The genotypes and allele frequencies for 67 HIV‐positive patients with lipodystrophy were compared with 50 HIV‐positive patients with no evidence of lipodystrophy and with 131 healthy HIV‐negative individuals. The presence of the TNFa5 allele could provide HIV/AIDS patients with protection against developing LS. The presence of TNF‐308G allele, as well as of its homozygote TNF‐308GG, were associated with susceptibility to developing LS. In addition, the presence of the haplotype TNFe3‐d3–238G–308A‐c1‐a5–b7 suggests protection against developing that syndrome. This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with LS development in HIV/AIDS patients. |
| doi_str_mv | 10.1111/j.1744-313X.2010.00937.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_860380263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>821199104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4377-7cfe368d9e5532be9fcf925d356d38f0f34d00c6cc1a63d207952e857c08b9ed3</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EoqXwFZBvnLLYceI4EheoaLvVqlzKH3GxvPaEenHi1PbCBvXD1-mWvYIvHtnv90YzDyFMyYLm83azoE1VFYyyb4uS5FdCWtYsdk_Q8eHj6aEu6RF6EeOGEMarijxHRyWpqRAVOUZ311dnuLc6-KgSOGcTYOUcOIi4VxPWfugg4DH4BDpZP2D1Q9khJpxuABv4Bc6PPQwJ-w47O3ozxRT8eDPhOA0m-B6wHfCHoP5YZ9WAL5Zf8KiSzUh8iZ51ykV49XifoM9nH69PL4rVp_Pl6ftVoSvWNEWjO2BcmBbqmpVraDvdtWVtWM0NEx3pWGUI0VxrqjgzJWnaugRRN5qIdQuGnaA3e988xu0WYpK9jTpPqwbw2ygFJ0yQkrN_K0tK25aSKivFXjmvLgbo5Bhsr8IkKZFzSHIj5_3LOQs5hyQfQpK7jL5-bLJd92AO4N9UsuDdXvDbOpj-21guL5e5yHixx21MsDvgKvyUvGFNLb9enWcn_r0Vq5Xk7B4hhrGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>821199104</pqid></control><display><type>article</type><title>TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Silva, M. M. ; Simões, R. T. ; Castelli, E. C. ; Mendes-Junior, C. T. ; Deghaide, N. H. S. ; Tsuda, L. C. ; Machado, A. A. ; Donadi, E. A. ; Fernandes, A. P. M.</creator><creatorcontrib>Silva, M. M. ; Simões, R. T. ; Castelli, E. C. ; Mendes-Junior, C. T. ; Deghaide, N. H. S. ; Tsuda, L. C. ; Machado, A. A. ; Donadi, E. A. ; Fernandes, A. P. M.</creatorcontrib><description>Summary
The aim of this study was to evaluate the frequency of TNFa–e microsatellites and the promoter region (TNF‐308 and TNF‐238) in HIV/AIDS‐infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case–control association study. Microsatellite and the TNF promoter region polymorphisms were amplified by PCR and submitted to polyacrylamide gel electrophoresis. The genotypes and allele frequencies for 67 HIV‐positive patients with lipodystrophy were compared with 50 HIV‐positive patients with no evidence of lipodystrophy and with 131 healthy HIV‐negative individuals. The presence of the TNFa5 allele could provide HIV/AIDS patients with protection against developing LS. The presence of TNF‐308G allele, as well as of its homozygote TNF‐308GG, were associated with susceptibility to developing LS. In addition, the presence of the haplotype TNFe3‐d3–238G–308A‐c1‐a5–b7 suggests protection against developing that syndrome. This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with LS development in HIV/AIDS patients.</description><identifier>ISSN: 1744-3121</identifier><identifier>EISSN: 1744-313X</identifier><identifier>DOI: 10.1111/j.1744-313X.2010.00937.x</identifier><identifier>PMID: 20518840</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Alleles ; Brazil ; Development ; Gel electrophoresis ; Gene Frequency ; Gene polymorphism ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; HIV Infections - complications ; HIV-Associated Lipodystrophy Syndrome - etiology ; HIV-Associated Lipodystrophy Syndrome - genetics ; Homozygotes ; Human immunodeficiency virus ; Humans ; Lipodystrophy ; Microsatellite Repeats - genetics ; Microsatellites ; Middle Aged ; Polymerase chain reaction ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Promoters ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - genetics</subject><ispartof>International journal of immunogenetics, 2010-10, Vol.37 (5), p.379-385</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2010 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4377-7cfe368d9e5532be9fcf925d356d38f0f34d00c6cc1a63d207952e857c08b9ed3</citedby><cites>FETCH-LOGICAL-c4377-7cfe368d9e5532be9fcf925d356d38f0f34d00c6cc1a63d207952e857c08b9ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1744-313X.2010.00937.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1744-313X.2010.00937.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20518840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, M. M.</creatorcontrib><creatorcontrib>Simões, R. T.</creatorcontrib><creatorcontrib>Castelli, E. C.</creatorcontrib><creatorcontrib>Mendes-Junior, C. T.</creatorcontrib><creatorcontrib>Deghaide, N. H. S.</creatorcontrib><creatorcontrib>Tsuda, L. C.</creatorcontrib><creatorcontrib>Machado, A. A.</creatorcontrib><creatorcontrib>Donadi, E. A.</creatorcontrib><creatorcontrib>Fernandes, A. P. M.</creatorcontrib><title>TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients</title><title>International journal of immunogenetics</title><addtitle>Int J Immunogenet</addtitle><description>Summary
The aim of this study was to evaluate the frequency of TNFa–e microsatellites and the promoter region (TNF‐308 and TNF‐238) in HIV/AIDS‐infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case–control association study. Microsatellite and the TNF promoter region polymorphisms were amplified by PCR and submitted to polyacrylamide gel electrophoresis. The genotypes and allele frequencies for 67 HIV‐positive patients with lipodystrophy were compared with 50 HIV‐positive patients with no evidence of lipodystrophy and with 131 healthy HIV‐negative individuals. The presence of the TNFa5 allele could provide HIV/AIDS patients with protection against developing LS. The presence of TNF‐308G allele, as well as of its homozygote TNF‐308GG, were associated with susceptibility to developing LS. In addition, the presence of the haplotype TNFe3‐d3–238G–308A‐c1‐a5–b7 suggests protection against developing that syndrome. This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with LS development in HIV/AIDS patients.</description><subject>Adult</subject><subject>Alleles</subject><subject>Brazil</subject><subject>Development</subject><subject>Gel electrophoresis</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>HIV Infections - complications</subject><subject>HIV-Associated Lipodystrophy Syndrome - etiology</subject><subject>HIV-Associated Lipodystrophy Syndrome - genetics</subject><subject>Homozygotes</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Lipodystrophy</subject><subject>Microsatellite Repeats - genetics</subject><subject>Microsatellites</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic</subject><subject>Promoter Regions, Genetic</subject><subject>Promoters</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>1744-3121</issn><issn>1744-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EoqXwFZBvnLLYceI4EheoaLvVqlzKH3GxvPaEenHi1PbCBvXD1-mWvYIvHtnv90YzDyFMyYLm83azoE1VFYyyb4uS5FdCWtYsdk_Q8eHj6aEu6RF6EeOGEMarijxHRyWpqRAVOUZ311dnuLc6-KgSOGcTYOUcOIi4VxPWfugg4DH4BDpZP2D1Q9khJpxuABv4Bc6PPQwJ-w47O3ozxRT8eDPhOA0m-B6wHfCHoP5YZ9WAL5Zf8KiSzUh8iZ51ykV49XifoM9nH69PL4rVp_Pl6ftVoSvWNEWjO2BcmBbqmpVraDvdtWVtWM0NEx3pWGUI0VxrqjgzJWnaugRRN5qIdQuGnaA3e988xu0WYpK9jTpPqwbw2ygFJ0yQkrN_K0tK25aSKivFXjmvLgbo5Bhsr8IkKZFzSHIj5_3LOQs5hyQfQpK7jL5-bLJd92AO4N9UsuDdXvDbOpj-21guL5e5yHixx21MsDvgKvyUvGFNLb9enWcn_r0Vq5Xk7B4hhrGA</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Silva, M. M.</creator><creator>Simões, R. T.</creator><creator>Castelli, E. C.</creator><creator>Mendes-Junior, C. T.</creator><creator>Deghaide, N. H. S.</creator><creator>Tsuda, L. C.</creator><creator>Machado, A. A.</creator><creator>Donadi, E. A.</creator><creator>Fernandes, A. P. M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201010</creationdate><title>TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients</title><author>Silva, M. M. ; Simões, R. T. ; Castelli, E. C. ; Mendes-Junior, C. T. ; Deghaide, N. H. S. ; Tsuda, L. C. ; Machado, A. A. ; Donadi, E. A. ; Fernandes, A. P. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4377-7cfe368d9e5532be9fcf925d356d38f0f34d00c6cc1a63d207952e857c08b9ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Brazil</topic><topic>Development</topic><topic>Gel electrophoresis</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>HIV Infections - complications</topic><topic>HIV-Associated Lipodystrophy Syndrome - etiology</topic><topic>HIV-Associated Lipodystrophy Syndrome - genetics</topic><topic>Homozygotes</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Lipodystrophy</topic><topic>Microsatellite Repeats - genetics</topic><topic>Microsatellites</topic><topic>Middle Aged</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Genetic</topic><topic>Promoter Regions, Genetic</topic><topic>Promoters</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, M. M.</creatorcontrib><creatorcontrib>Simões, R. T.</creatorcontrib><creatorcontrib>Castelli, E. C.</creatorcontrib><creatorcontrib>Mendes-Junior, C. T.</creatorcontrib><creatorcontrib>Deghaide, N. H. S.</creatorcontrib><creatorcontrib>Tsuda, L. C.</creatorcontrib><creatorcontrib>Machado, A. A.</creatorcontrib><creatorcontrib>Donadi, E. A.</creatorcontrib><creatorcontrib>Fernandes, A. P. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>International journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, M. M.</au><au>Simões, R. T.</au><au>Castelli, E. C.</au><au>Mendes-Junior, C. T.</au><au>Deghaide, N. H. S.</au><au>Tsuda, L. C.</au><au>Machado, A. A.</au><au>Donadi, E. A.</au><au>Fernandes, A. P. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients</atitle><jtitle>International journal of immunogenetics</jtitle><addtitle>Int J Immunogenet</addtitle><date>2010-10</date><risdate>2010</risdate><volume>37</volume><issue>5</issue><spage>379</spage><epage>385</epage><pages>379-385</pages><issn>1744-3121</issn><eissn>1744-313X</eissn><abstract>Summary
The aim of this study was to evaluate the frequency of TNFa–e microsatellites and the promoter region (TNF‐308 and TNF‐238) in HIV/AIDS‐infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case–control association study. Microsatellite and the TNF promoter region polymorphisms were amplified by PCR and submitted to polyacrylamide gel electrophoresis. The genotypes and allele frequencies for 67 HIV‐positive patients with lipodystrophy were compared with 50 HIV‐positive patients with no evidence of lipodystrophy and with 131 healthy HIV‐negative individuals. The presence of the TNFa5 allele could provide HIV/AIDS patients with protection against developing LS. The presence of TNF‐308G allele, as well as of its homozygote TNF‐308GG, were associated with susceptibility to developing LS. In addition, the presence of the haplotype TNFe3‐d3–238G–308A‐c1‐a5–b7 suggests protection against developing that syndrome. This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with LS development in HIV/AIDS patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20518840</pmid><doi>10.1111/j.1744-313X.2010.00937.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1744-3121 |
| ispartof | International journal of immunogenetics, 2010-10, Vol.37 (5), p.379-385 |
| issn | 1744-3121 1744-313X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_860380263 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Alleles Brazil Development Gel electrophoresis Gene Frequency Gene polymorphism Genetic Predisposition to Disease Genotype Haplotypes HIV Infections - complications HIV-Associated Lipodystrophy Syndrome - etiology HIV-Associated Lipodystrophy Syndrome - genetics Homozygotes Human immunodeficiency virus Humans Lipodystrophy Microsatellite Repeats - genetics Microsatellites Middle Aged Polymerase chain reaction Polymorphism, Genetic Promoter Regions, Genetic Promoters Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics |
| title | TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T22%3A38%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TNF%20microsatellite%20alleles%20may%20confer%20protection%20against%20the%20development%20of%20lipodystrophy%20syndrome%20in%20Brazilian%20HIV%20patients&rft.jtitle=International%20journal%20of%20immunogenetics&rft.au=Silva,%20M.%20M.&rft.date=2010-10&rft.volume=37&rft.issue=5&rft.spage=379&rft.epage=385&rft.pages=379-385&rft.issn=1744-3121&rft.eissn=1744-313X&rft_id=info:doi/10.1111/j.1744-313X.2010.00937.x&rft_dat=%3Cproquest_cross%3E821199104%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=821199104&rft_id=info:pmid/20518840&rfr_iscdi=true |