Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test

▶ MCHergic fibers were present in the dorsal raphe nucleus (DRN) of the rat. ▶ MCH applied into the DRN produced a depressive-like effect evaluated in the forced swimming test (FST). This effect was prevented by fluoxetine. ▶ Immunoneutralization of MCH in the DRN produced an antidepressant-like eff...

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Veröffentlicht in:	Behavioural brain research 2011-04, Vol.218 (2), p.259-266
Hauptverfasser:	Lagos, Patricia, Urbanavicius, Jessika, Scorza, María Cecilia, Miraballes, Rodrigo, Torterolo, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Analysis of Variance Animals Antibodies, Neutralizing Behavioral psychophysiology Biological and medical sciences Depression Depression - chemically induced Depression - metabolism Emotions - drug effects Fundamental and applied biological sciences. Psychology Hypothalamic Hormones - administration & dosage Hypothalamic Hormones - metabolism Hypothalamus Immunohistochemistry Male Medical sciences Melanins - administration & dosage Melanins - metabolism Microinjections Mood disorders Motor Activity - drug effects Neurons - drug effects Neurons - metabolism Neuropeptide Open field test Pituitary Hormones - administration & dosage Pituitary Hormones - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley Swimming
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