Identification of cytomegalovirus (CMV)pp65 antigen-specific human monoclonal antibodies using single B cell-based antibody gene cloning from melanoma patients

Abstract Recently, because of highly advanced protein engineering technology, beyond the chimeric antibody, highly humanized and fully human antibody development is becoming crucial in the medical field. In the last decade, investigational approaches using clinical samples for fully human antibody p...

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Veröffentlicht in:	Immunology letters 2011-03, Vol.135 (1), p.64-73
Hauptverfasser:	Iizuka, Akira, Komiyama, Masaru, Tai, Sachiko, Oshita, Chie, Kurusu, Ayumi, Kume, Akiko, Ozawa, Kazumichi, Nakamura, Yoji, Ashizawa, Tadashi, Yamamoto, Akifumi, Yamazaki, Naoya, Yoshikawa, Shusuke, Kiyohara, Yoshio, Yamaguchi, Ken, Akiyama, Yasuto
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Allergy and Immunology Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Viral - genetics Antibodies, Viral - immunology B-Lymphocytes - immunology Cloning, Molecular copy number Cytomegalovirus - genetics Cytomegalovirus - immunology Cytomegalovirus pp65 antigen Direct antibody gene cloning Enzyme-linked immunosorbent assay Heavy chains Human cytomegalovirus Human IgG ELISA Human monoclonal antibody Humans IGL gene Immunoglobulin G Immunoglobulin G - immunology Immunoglobulins Lymphocytes B Melanoma Monoclonal antibodies mRNA Phosphoproteins - genetics Phosphoproteins - immunology Polymerase chain reaction Protein engineering Single B cell Single-Chain Antibodies - genetics Single-Chain Antibodies - immunology Viral Matrix Proteins - genetics Viral Matrix Proteins - immunology
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