Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients
Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naïve Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT regi...
Gespeichert in:
| Veröffentlicht in: | Antiviral research 2010-03, Vol.85 (3), p.512-519 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 519 |
|---|---|
| container_issue | 3 |
| container_start_page | 512 |
| container_title | Antiviral research |
| container_volume | 85 |
| creator | Liu, Bao-Ming Li, Tong Xu, Jie Li, Xiao-Guang Dong, Jian-Ping Yan, Ping Yang, Jing-Xian Yan, Ling Gao, Zhi-Yong Li, Wen-Peng Sun, Xie-Wen Wang, Yu-Hua Jiao, Xiu-Juan Hou, Chun-Sheng Zhuang, Hui |
| description | Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naïve Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT region were analyzed. Patients were found with either B-genotype (28.65%) or C-genotype (71.35%) infections. Rt53, rt91, rt124, rt134, rt221, rt224, rt238 and rt256 were identified as B- and C-genotype-dependent polymorphic AA positions. AA substitutions at 11 classical NAr mutation positions, i.e. rt80, rt169, rt173, rt180, rt181, rt184, rt194, rt202, rt204, rt236 and rt250, were not detected. However, potential NAr mutations were found in 30.73% (59/192) isolates, which involved 18 positions including rt53, rt207, rt229, rt238 and rt256, etc. The concomitant AA changes of HBsAg occurred in 16.67% (32/192) isolates including sG145R mutation. One-third of mutation positions were located in functional RT domains (e.g. rt207 and rt233), A–B interdomains (overlapping HBsAg ‘a’ determinant and showing most concomitant immune-associated mutations) and non-A–B interdomains (e.g. rt191 and rt213), respectively. Genotypes B and C each showed several preferred positions to mutate. These results might provide insights into understanding the evolution and selection basis of NAr HBV strains under antiviral therapy. |
| doi_str_mv | 10.1016/j.antiviral.2009.12.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_860373897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166354209005452</els_id><sourcerecordid>733682850</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-9373098182a51c055bebf300a11bfa225c6b35dd681b19fbbaf5cbbe1386999c3</originalsourceid><addsrcrecordid>eNqFkU2OEzEQhS0EYsLAFcAbxKob_8Td9nKImAFpJDawtmx3teKo_7CdSHAQrsEhuBiVSQjLWVllfa9e6T1C3nBWc8ab97vaTSUeYnJDLRgzNRc1Y80TsuK6FZVhpnlKVkg2lVRrcUVe5LxjSLRGPydXKJFrJfiK_NpsXXKhQIo_XYnzROeeLnMBXO8GenGhCXLMxU0B6LgvD2imcaJbWHAoMdMPFMl9RvIAKQMtyU05pLgUh1OG73tA9YOoJHBlRI9qcn9-H4ButnECpI678Du_JM96N2R4dX6vybfbj183n6r7L3efNzf3VVgbXSojW8mM5lo4xQNTyoPvJWOOc987IVRovFRd12juuem9d70K3gOXujHGBHlN3p32LmnG-3KxY8wBhsFNMO-z1Q1DC23aR8lWykYLrRiS7YkMac45QW-XFEeXfljO7LE9u7OXXO2xPcuFxW5Q-frssfcjdBfdv7oQeHsGXA5u6DHhEPN_TqyNaZRG7ubEAWZ3iJBsDvGYfhcThGK7OT56zF845sI6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733682850</pqid></control><display><type>article</type><title>Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Liu, Bao-Ming ; Li, Tong ; Xu, Jie ; Li, Xiao-Guang ; Dong, Jian-Ping ; Yan, Ping ; Yang, Jing-Xian ; Yan, Ling ; Gao, Zhi-Yong ; Li, Wen-Peng ; Sun, Xie-Wen ; Wang, Yu-Hua ; Jiao, Xiu-Juan ; Hou, Chun-Sheng ; Zhuang, Hui</creator><creatorcontrib>Liu, Bao-Ming ; Li, Tong ; Xu, Jie ; Li, Xiao-Guang ; Dong, Jian-Ping ; Yan, Ping ; Yang, Jing-Xian ; Yan, Ling ; Gao, Zhi-Yong ; Li, Wen-Peng ; Sun, Xie-Wen ; Wang, Yu-Hua ; Jiao, Xiu-Juan ; Hou, Chun-Sheng ; Zhuang, Hui</creatorcontrib><description>Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naïve Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT region were analyzed. Patients were found with either B-genotype (28.65%) or C-genotype (71.35%) infections. Rt53, rt91, rt124, rt134, rt221, rt224, rt238 and rt256 were identified as B- and C-genotype-dependent polymorphic AA positions. AA substitutions at 11 classical NAr mutation positions, i.e. rt80, rt169, rt173, rt180, rt181, rt184, rt194, rt202, rt204, rt236 and rt250, were not detected. However, potential NAr mutations were found in 30.73% (59/192) isolates, which involved 18 positions including rt53, rt207, rt229, rt238 and rt256, etc. The concomitant AA changes of HBsAg occurred in 16.67% (32/192) isolates including sG145R mutation. One-third of mutation positions were located in functional RT domains (e.g. rt207 and rt233), A–B interdomains (overlapping HBsAg ‘a’ determinant and showing most concomitant immune-associated mutations) and non-A–B interdomains (e.g. rt191 and rt213), respectively. Genotypes B and C each showed several preferred positions to mutate. These results might provide insights into understanding the evolution and selection basis of NAr HBV strains under antiviral therapy.</description><identifier>ISSN: 0166-3542</identifier><identifier>EISSN: 1872-9096</identifier><identifier>DOI: 10.1016/j.antiviral.2009.12.006</identifier><identifier>PMID: 20034521</identifier><identifier>CODEN: ARSRDR</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amino Acid Substitution - genetics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - pharmacology ; Biological and medical sciences ; China ; Drug Resistance, Viral ; Female ; Genotype ; Hepatitis B Surface Antigens - genetics ; Hepatitis B virus ; Hepatitis B virus - drug effects ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - virology ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Mutation ; Mutation, Missense ; Nucleos(t)ide analogue naïve ; Pharmacology. Drug treatments ; Polymorphic ; Resistance ; RNA-Directed DNA Polymerase - genetics ; Sequence Analysis, DNA ; Viral diseases ; Viral hepatitis ; Young Adult</subject><ispartof>Antiviral research, 2010-03, Vol.85 (3), p.512-519</ispartof><rights>2009 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-9373098182a51c055bebf300a11bfa225c6b35dd681b19fbbaf5cbbe1386999c3</citedby><cites>FETCH-LOGICAL-c498t-9373098182a51c055bebf300a11bfa225c6b35dd681b19fbbaf5cbbe1386999c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.antiviral.2009.12.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22499658$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20034521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Bao-Ming</creatorcontrib><creatorcontrib>Li, Tong</creatorcontrib><creatorcontrib>Xu, Jie</creatorcontrib><creatorcontrib>Li, Xiao-Guang</creatorcontrib><creatorcontrib>Dong, Jian-Ping</creatorcontrib><creatorcontrib>Yan, Ping</creatorcontrib><creatorcontrib>Yang, Jing-Xian</creatorcontrib><creatorcontrib>Yan, Ling</creatorcontrib><creatorcontrib>Gao, Zhi-Yong</creatorcontrib><creatorcontrib>Li, Wen-Peng</creatorcontrib><creatorcontrib>Sun, Xie-Wen</creatorcontrib><creatorcontrib>Wang, Yu-Hua</creatorcontrib><creatorcontrib>Jiao, Xiu-Juan</creatorcontrib><creatorcontrib>Hou, Chun-Sheng</creatorcontrib><creatorcontrib>Zhuang, Hui</creatorcontrib><title>Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients</title><title>Antiviral research</title><addtitle>Antiviral Res</addtitle><description>Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naïve Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT region were analyzed. Patients were found with either B-genotype (28.65%) or C-genotype (71.35%) infections. Rt53, rt91, rt124, rt134, rt221, rt224, rt238 and rt256 were identified as B- and C-genotype-dependent polymorphic AA positions. AA substitutions at 11 classical NAr mutation positions, i.e. rt80, rt169, rt173, rt180, rt181, rt184, rt194, rt202, rt204, rt236 and rt250, were not detected. However, potential NAr mutations were found in 30.73% (59/192) isolates, which involved 18 positions including rt53, rt207, rt229, rt238 and rt256, etc. The concomitant AA changes of HBsAg occurred in 16.67% (32/192) isolates including sG145R mutation. One-third of mutation positions were located in functional RT domains (e.g. rt207 and rt233), A–B interdomains (overlapping HBsAg ‘a’ determinant and showing most concomitant immune-associated mutations) and non-A–B interdomains (e.g. rt191 and rt213), respectively. Genotypes B and C each showed several preferred positions to mutate. These results might provide insights into understanding the evolution and selection basis of NAr HBV strains under antiviral therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acid Substitution - genetics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Drug Resistance, Viral</subject><subject>Female</subject><subject>Genotype</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - drug effects</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>Nucleos(t)ide analogue naïve</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphic</subject><subject>Resistance</subject><subject>RNA-Directed DNA Polymerase - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Young Adult</subject><issn>0166-3542</issn><issn>1872-9096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2OEzEQhS0EYsLAFcAbxKob_8Td9nKImAFpJDawtmx3teKo_7CdSHAQrsEhuBiVSQjLWVllfa9e6T1C3nBWc8ab97vaTSUeYnJDLRgzNRc1Y80TsuK6FZVhpnlKVkg2lVRrcUVe5LxjSLRGPydXKJFrJfiK_NpsXXKhQIo_XYnzROeeLnMBXO8GenGhCXLMxU0B6LgvD2imcaJbWHAoMdMPFMl9RvIAKQMtyU05pLgUh1OG73tA9YOoJHBlRI9qcn9-H4ButnECpI678Du_JM96N2R4dX6vybfbj183n6r7L3efNzf3VVgbXSojW8mM5lo4xQNTyoPvJWOOc987IVRovFRd12juuem9d70K3gOXujHGBHlN3p32LmnG-3KxY8wBhsFNMO-z1Q1DC23aR8lWykYLrRiS7YkMac45QW-XFEeXfljO7LE9u7OXXO2xPcuFxW5Q-frssfcjdBfdv7oQeHsGXA5u6DHhEPN_TqyNaZRG7ubEAWZ3iJBsDvGYfhcThGK7OT56zF845sI6</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Liu, Bao-Ming</creator><creator>Li, Tong</creator><creator>Xu, Jie</creator><creator>Li, Xiao-Guang</creator><creator>Dong, Jian-Ping</creator><creator>Yan, Ping</creator><creator>Yang, Jing-Xian</creator><creator>Yan, Ling</creator><creator>Gao, Zhi-Yong</creator><creator>Li, Wen-Peng</creator><creator>Sun, Xie-Wen</creator><creator>Wang, Yu-Hua</creator><creator>Jiao, Xiu-Juan</creator><creator>Hou, Chun-Sheng</creator><creator>Zhuang, Hui</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20100301</creationdate><title>Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients</title><author>Liu, Bao-Ming ; Li, Tong ; Xu, Jie ; Li, Xiao-Guang ; Dong, Jian-Ping ; Yan, Ping ; Yang, Jing-Xian ; Yan, Ling ; Gao, Zhi-Yong ; Li, Wen-Peng ; Sun, Xie-Wen ; Wang, Yu-Hua ; Jiao, Xiu-Juan ; Hou, Chun-Sheng ; Zhuang, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-9373098182a51c055bebf300a11bfa225c6b35dd681b19fbbaf5cbbe1386999c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino Acid Substitution - genetics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Drug Resistance, Viral</topic><topic>Female</topic><topic>Genotype</topic><topic>Hepatitis B Surface Antigens - genetics</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - drug effects</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Mutation, Missense</topic><topic>Nucleos(t)ide analogue naïve</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphic</topic><topic>Resistance</topic><topic>RNA-Directed DNA Polymerase - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Bao-Ming</creatorcontrib><creatorcontrib>Li, Tong</creatorcontrib><creatorcontrib>Xu, Jie</creatorcontrib><creatorcontrib>Li, Xiao-Guang</creatorcontrib><creatorcontrib>Dong, Jian-Ping</creatorcontrib><creatorcontrib>Yan, Ping</creatorcontrib><creatorcontrib>Yang, Jing-Xian</creatorcontrib><creatorcontrib>Yan, Ling</creatorcontrib><creatorcontrib>Gao, Zhi-Yong</creatorcontrib><creatorcontrib>Li, Wen-Peng</creatorcontrib><creatorcontrib>Sun, Xie-Wen</creatorcontrib><creatorcontrib>Wang, Yu-Hua</creatorcontrib><creatorcontrib>Jiao, Xiu-Juan</creatorcontrib><creatorcontrib>Hou, Chun-Sheng</creatorcontrib><creatorcontrib>Zhuang, Hui</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Antiviral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Bao-Ming</au><au>Li, Tong</au><au>Xu, Jie</au><au>Li, Xiao-Guang</au><au>Dong, Jian-Ping</au><au>Yan, Ping</au><au>Yang, Jing-Xian</au><au>Yan, Ling</au><au>Gao, Zhi-Yong</au><au>Li, Wen-Peng</au><au>Sun, Xie-Wen</au><au>Wang, Yu-Hua</au><au>Jiao, Xiu-Juan</au><au>Hou, Chun-Sheng</au><au>Zhuang, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients</atitle><jtitle>Antiviral research</jtitle><addtitle>Antiviral Res</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>85</volume><issue>3</issue><spage>512</spage><epage>519</epage><pages>512-519</pages><issn>0166-3542</issn><eissn>1872-9096</eissn><coden>ARSRDR</coden><abstract>Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naïve Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT region were analyzed. Patients were found with either B-genotype (28.65%) or C-genotype (71.35%) infections. Rt53, rt91, rt124, rt134, rt221, rt224, rt238 and rt256 were identified as B- and C-genotype-dependent polymorphic AA positions. AA substitutions at 11 classical NAr mutation positions, i.e. rt80, rt169, rt173, rt180, rt181, rt184, rt194, rt202, rt204, rt236 and rt250, were not detected. However, potential NAr mutations were found in 30.73% (59/192) isolates, which involved 18 positions including rt53, rt207, rt229, rt238 and rt256, etc. The concomitant AA changes of HBsAg occurred in 16.67% (32/192) isolates including sG145R mutation. One-third of mutation positions were located in functional RT domains (e.g. rt207 and rt233), A–B interdomains (overlapping HBsAg ‘a’ determinant and showing most concomitant immune-associated mutations) and non-A–B interdomains (e.g. rt191 and rt213), respectively. Genotypes B and C each showed several preferred positions to mutate. These results might provide insights into understanding the evolution and selection basis of NAr HBV strains under antiviral therapy.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>20034521</pmid><doi>10.1016/j.antiviral.2009.12.006</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-3542 |
| ispartof | Antiviral research, 2010-03, Vol.85 (3), p.512-519 |
| issn | 0166-3542 1872-9096 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_860373897 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Aged Aged, 80 and over Amino Acid Substitution - genetics Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences China Drug Resistance, Viral Female Genotype Hepatitis B Surface Antigens - genetics Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - virology Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Molecular Sequence Data Mutation Mutation, Missense Nucleos(t)ide analogue naïve Pharmacology. Drug treatments Polymorphic Resistance RNA-Directed DNA Polymerase - genetics Sequence Analysis, DNA Viral diseases Viral hepatitis Young Adult |
| title | Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A32%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20potential%20antiviral%20resistance%20mutations%20in%20hepatitis%20B%20virus%20reverse%20transcriptase%20sequences%20in%20treatment-na%C3%AFve%20Chinese%20patients&rft.jtitle=Antiviral%20research&rft.au=Liu,%20Bao-Ming&rft.date=2010-03-01&rft.volume=85&rft.issue=3&rft.spage=512&rft.epage=519&rft.pages=512-519&rft.issn=0166-3542&rft.eissn=1872-9096&rft.coden=ARSRDR&rft_id=info:doi/10.1016/j.antiviral.2009.12.006&rft_dat=%3Cproquest_cross%3E733682850%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733682850&rft_id=info:pmid/20034521&rft_els_id=S0166354209005452&rfr_iscdi=true |