Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

Interleukin (IL)-10 is a regulatory cytokine of the helper T cell type 2 (TH2) pathway, which underlies both the host defense to helminthic infection and atopic diseases, including asthma. Although IL10 promoter polymorphisms are associated with increased atopy risk, IL10 variation has not been thor...

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Veröffentlicht in:	Genes and immunity 2011-01, Vol.12 (1), p.46-50
Hauptverfasser:	Grant, A V, Araujo, M I, Ponte, E V, Oliveira, R R, Cruz, A A, Barnes, K C, Beaty, T H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/727/2000 631/250/127/1213 631/250/1619/554/1898/1274 692/420/254 Adolescent Adult Aged Aged, 80 and over Allergens Animals Asthma Atopy Biomedical and Life Sciences Biomedicine Brazil Cancer Research Child Cytokines Female Gene Expression Genes Genetic aspects Haplotypes Human Genetics Humans Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulins Immunology Infections Interleukin 1 Interleukin 10 Interleukin-10 - genetics Lymphocytes T Male Middle Aged Nuclear family Physiological aspects Polymorphism, Single Nucleotide Population Promoter Regions, Genetic Public health Risk factors Schistosoma mansoni Schistosoma mansoni - physiology Schistosomiasis Schistosomiasis mansoni - genetics Schistosomiasis mansoni - immunology short-communication Single nucleotide polymorphisms Single-nucleotide polymorphism Young Adult
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