Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex
Two key models for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD). Combining DNA microarray analysis with computational approac...
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| Veröffentlicht in: | Nature neuroscience 2006-05, Vol.9 (5), p.660-668 |
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| creator | Tropea, Daniela Kreiman, Gabriel Lyckman, Alvin Mukherjee, Sayan Yu, Hongbo Horng, Sam Sur, Mriganka |
| description | Two key models for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD). Combining DNA microarray analysis with computational approaches, RT-PCR, immunohistochemistry and physiological imaging, we find that DR leads to (i) upregulation of genes subserving synaptic transmission and electrical activity, consistent with a coordinated response of cortical neurons to reduction of visual drive, and (ii) downregulation of parvalbumin expression, implicating parvalbumin-expressing interneurons as underlying the delay in cortical maturation after DR. MD partially activates homeostatic mechanisms but differentially upregulates molecular pathways related to growth factors and neuronal degeneration, consistent with reorganization of connections after MD. Expression of a binding protein of insulin-like growth factor-1 (IGF1) is highly upregulated after MD, and exogenous application of IGF1 prevents the physiological effects of MD on ocular dominance plasticity examined
in vivo
. |
| doi_str_mv | 10.1038/nn1689 |
| format | Article |
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in vivo
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in vivo
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Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tropea, Daniela</au><au>Kreiman, Gabriel</au><au>Lyckman, Alvin</au><au>Mukherjee, Sayan</au><au>Yu, Hongbo</au><au>Horng, Sam</au><au>Sur, Mriganka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>9</volume><issue>5</issue><spage>660</spage><epage>668</epage><pages>660-668</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Two key models for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD). Combining DNA microarray analysis with computational approaches, RT-PCR, immunohistochemistry and physiological imaging, we find that DR leads to (i) upregulation of genes subserving synaptic transmission and electrical activity, consistent with a coordinated response of cortical neurons to reduction of visual drive, and (ii) downregulation of parvalbumin expression, implicating parvalbumin-expressing interneurons as underlying the delay in cortical maturation after DR. MD partially activates homeostatic mechanisms but differentially upregulates molecular pathways related to growth factors and neuronal degeneration, consistent with reorganization of connections after MD. Expression of a binding protein of insulin-like growth factor-1 (IGF1) is highly upregulated after MD, and exogenous application of IGF1 prevents the physiological effects of MD on ocular dominance plasticity examined
in vivo
.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16633343</pmid><doi>10.1038/nn1689</doi><tpages>9</tpages></addata></record> |
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| subjects | Animal Genetics and Genomics Animals Animals, Newborn Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Darkness Gene expression Gene Expression Regulation - physiology Immunohistochemistry - methods Mice Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurobiology Neuronal Plasticity - physiology Neuroplasticity Neurosciences Oligonucleotide Array Sequence Analysis - methods Physiological aspects Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Sensory Deprivation - physiology Signal Transduction - physiology Vision, Binocular - physiology Vision, Monocular - physiology Visual cortex Visual Cortex - cytology Visual Cortex - physiology Visual Pathways - physiology |
| title | Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex |
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