Development of a health care personnel handwash with 6-hour persistence
Background Health care handwashes/sanitizers help prevent the spread of infection. Many are alcohol-based, providing immediate microbial kill. Few contain persistence factors for residual antimicrobial effects. We conducted multiple studies on Viacydin-Containing Alcohol Sanitizer (VCAS) to evaluate...
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| Veröffentlicht in: | American journal of infection control 2011-04, Vol.39 (3), p.226-234 |
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| container_title | American journal of infection control |
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| creator | Cargill, D. Innes, PhD Roche, Eric D., PhD Van Der Kar, Catherine A., BS Slade, Herbert B., MD Aust, Duncan T., PhD Carson, Dennis L., PhD, DABT Seal, Lawton A., PhD |
| description | Background Health care handwashes/sanitizers help prevent the spread of infection. Many are alcohol-based, providing immediate microbial kill. Few contain persistence factors for residual antimicrobial effects. We conducted multiple studies on Viacydin-Containing Alcohol Sanitizer (VCAS) to evaluate antimicrobial properties and skin friendliness. Methods The potential of VCAS to cause use related skin problems was examined by repeated applications over a 3-week period. Excessive handwashing compared effects of VCAS on the skin barrier with that of other handwash products. Antimicrobial range, immediate kill rates, and resistance development were assessed as was the potential for continued antimicrobial activity over an extended period following product use. Results Our data showed the VCAS formula has broad, rapid antimicrobial efficacy without promoting microbial resistance. VCAS is mild to skin. Antimicrobial persistence testing showed that VCAS remained effective up to 6 hours postapplication. Conclusion VCAS was superior to or at parity with on-market products, exhibited substantial residual effects and persistence up to 6 hours, and was safe and well tolerated. These results provide strong evidence for the value of VCAS to help prevent and eliminate pathogen contamination of the hands. |
| doi_str_mv | 10.1016/j.ajic.2011.02.001 |
| format | Article |
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Innes, PhD ; Roche, Eric D., PhD ; Van Der Kar, Catherine A., BS ; Slade, Herbert B., MD ; Aust, Duncan T., PhD ; Carson, Dennis L., PhD, DABT ; Seal, Lawton A., PhD</creator><creatorcontrib>Cargill, D. Innes, PhD ; Roche, Eric D., PhD ; Van Der Kar, Catherine A., BS ; Slade, Herbert B., MD ; Aust, Duncan T., PhD ; Carson, Dennis L., PhD, DABT ; Seal, Lawton A., PhD</creatorcontrib><description>Background Health care handwashes/sanitizers help prevent the spread of infection. Many are alcohol-based, providing immediate microbial kill. Few contain persistence factors for residual antimicrobial effects. We conducted multiple studies on Viacydin-Containing Alcohol Sanitizer (VCAS) to evaluate antimicrobial properties and skin friendliness. Methods The potential of VCAS to cause use related skin problems was examined by repeated applications over a 3-week period. Excessive handwashing compared effects of VCAS on the skin barrier with that of other handwash products. Antimicrobial range, immediate kill rates, and resistance development were assessed as was the potential for continued antimicrobial activity over an extended period following product use. Results Our data showed the VCAS formula has broad, rapid antimicrobial efficacy without promoting microbial resistance. VCAS is mild to skin. Antimicrobial persistence testing showed that VCAS remained effective up to 6 hours postapplication. Conclusion VCAS was superior to or at parity with on-market products, exhibited substantial residual effects and persistence up to 6 hours, and was safe and well tolerated. These results provide strong evidence for the value of VCAS to help prevent and eliminate pathogen contamination of the hands.</description><identifier>ISSN: 0196-6553</identifier><identifier>EISSN: 1527-3296</identifier><identifier>DOI: 10.1016/j.ajic.2011.02.001</identifier><identifier>PMID: 21458685</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Alcohols - administration & dosage ; Alcohols - adverse effects ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; antimicrobial activity ; Antimicrobial agents ; antimicrobial persistence ; Antiseptics ; Bacterial Load ; Biological and medical sciences ; Disease control ; Disease prevention ; Disinfectants - administration & dosage ; Disinfectants - adverse effects ; Epidemiology. Vaccinations ; General aspects ; Hand - microbiology ; Hand Disinfection - methods ; hand sanitizers ; Health care handwash ; Health Personnel ; Humans ; Hygiene ; Infection Control ; Infectious Disease ; Infectious diseases ; Medical sciences ; Pathogens ; Pharmacology. Drug treatments ; Skin - microbiology ; Sterilization ; surgical scrub ; Time Factors</subject><ispartof>American journal of infection control, 2011-04, Vol.39 (3), p.226-234</ispartof><rights>Association for Professionals in Infection Control and Epidemiology, Inc.</rights><rights>2011 Association for Professionals in Infection Control and Epidemiology, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Mosby-Year Book, Inc. Apr 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-d4cfaf4bb33c710957f6a8e8e571516bb30f2f401471fd60449dfbf510b2ae5c3</citedby><cites>FETCH-LOGICAL-c467t-d4cfaf4bb33c710957f6a8e8e571516bb30f2f401471fd60449dfbf510b2ae5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajic.2011.02.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24070059$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21458685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cargill, D. Innes, PhD</creatorcontrib><creatorcontrib>Roche, Eric D., PhD</creatorcontrib><creatorcontrib>Van Der Kar, Catherine A., BS</creatorcontrib><creatorcontrib>Slade, Herbert B., MD</creatorcontrib><creatorcontrib>Aust, Duncan T., PhD</creatorcontrib><creatorcontrib>Carson, Dennis L., PhD, DABT</creatorcontrib><creatorcontrib>Seal, Lawton A., PhD</creatorcontrib><title>Development of a health care personnel handwash with 6-hour persistence</title><title>American journal of infection control</title><addtitle>Am J Infect Control</addtitle><description>Background Health care handwashes/sanitizers help prevent the spread of infection. Many are alcohol-based, providing immediate microbial kill. Few contain persistence factors for residual antimicrobial effects. We conducted multiple studies on Viacydin-Containing Alcohol Sanitizer (VCAS) to evaluate antimicrobial properties and skin friendliness. Methods The potential of VCAS to cause use related skin problems was examined by repeated applications over a 3-week period. Excessive handwashing compared effects of VCAS on the skin barrier with that of other handwash products. Antimicrobial range, immediate kill rates, and resistance development were assessed as was the potential for continued antimicrobial activity over an extended period following product use. Results Our data showed the VCAS formula has broad, rapid antimicrobial efficacy without promoting microbial resistance. VCAS is mild to skin. Antimicrobial persistence testing showed that VCAS remained effective up to 6 hours postapplication. Conclusion VCAS was superior to or at parity with on-market products, exhibited substantial residual effects and persistence up to 6 hours, and was safe and well tolerated. These results provide strong evidence for the value of VCAS to help prevent and eliminate pathogen contamination of the hands.</description><subject>Adult</subject><subject>Alcohols - administration & dosage</subject><subject>Alcohols - adverse effects</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>antimicrobial persistence</subject><subject>Antiseptics</subject><subject>Bacterial Load</subject><subject>Biological and medical sciences</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Disinfectants - administration & dosage</subject><subject>Disinfectants - adverse effects</subject><subject>Epidemiology. Vaccinations</subject><subject>General aspects</subject><subject>Hand - microbiology</subject><subject>Hand Disinfection - methods</subject><subject>hand sanitizers</subject><subject>Health care handwash</subject><subject>Health Personnel</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Infection Control</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Pathogens</subject><subject>Pharmacology. Drug treatments</subject><subject>Skin - microbiology</subject><subject>Sterilization</subject><subject>surgical scrub</subject><subject>Time Factors</subject><issn>0196-6553</issn><issn>1527-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9klFr1TAUx4Mo7jr9Aj5IEcSnduekSdqCCDJ1EwZ7UJ9Dmp7Q1N72mvRu7Nsv9V4n7MGnQPL7n5zz4zD2GqFAQHU2FGbwtuCAWAAvAPAJ26DkVV7yRj1lG8BG5UrK8oS9iHEAgKZU8jk74ShkrWq5YRef6YbGebelaclml5msJzMufWZNoGxHIc7TRGPWm6m7NbHPbn16VHk_78OfZx8Xmiy9ZM-cGSO9Op6n7OfXLz_OL_Or64tv55-ucitUteSdsM440bZlaSuERlZOmZpqkhVKVOkeHHcCUFToOgVCNJ1rnURouSFpy1P2_lB3F-bfe4qL3vpoaRzNRPM-6lqloVHxJpFvH5FD6nlKzSVIlSJ5qRLED5ANc4yBnN4FvzXhTiPoVbIe9CpZr5I1cJ0kp9CbY-V9u6XuIfLXagLeHQETrRldMJP18R8noAKQa4sfDhwlYzeego7WrzY7H8guupv9__v4-ChuRz_59OMvuqP4MC7qmAL6-7oO6zYgpjQIKO8B8Lit7g</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Cargill, D. Innes, PhD</creator><creator>Roche, Eric D., PhD</creator><creator>Van Der Kar, Catherine A., BS</creator><creator>Slade, Herbert B., MD</creator><creator>Aust, Duncan T., PhD</creator><creator>Carson, Dennis L., PhD, DABT</creator><creator>Seal, Lawton A., PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Mosby-Year Book, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Development of a health care personnel handwash with 6-hour persistence</title><author>Cargill, D. Innes, PhD ; Roche, Eric D., PhD ; Van Der Kar, Catherine A., BS ; Slade, Herbert B., MD ; Aust, Duncan T., PhD ; Carson, Dennis L., PhD, DABT ; Seal, Lawton A., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-d4cfaf4bb33c710957f6a8e8e571516bb30f2f401471fd60449dfbf510b2ae5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alcohols - administration & dosage</topic><topic>Alcohols - adverse effects</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>antimicrobial persistence</topic><topic>Antiseptics</topic><topic>Bacterial Load</topic><topic>Biological and medical sciences</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>Disinfectants - administration & dosage</topic><topic>Disinfectants - adverse effects</topic><topic>Epidemiology. Vaccinations</topic><topic>General aspects</topic><topic>Hand - microbiology</topic><topic>Hand Disinfection - methods</topic><topic>hand sanitizers</topic><topic>Health care handwash</topic><topic>Health Personnel</topic><topic>Humans</topic><topic>Hygiene</topic><topic>Infection Control</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Pathogens</topic><topic>Pharmacology. Drug treatments</topic><topic>Skin - microbiology</topic><topic>Sterilization</topic><topic>surgical scrub</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cargill, D. Innes, PhD</creatorcontrib><creatorcontrib>Roche, Eric D., PhD</creatorcontrib><creatorcontrib>Van Der Kar, Catherine A., BS</creatorcontrib><creatorcontrib>Slade, Herbert B., MD</creatorcontrib><creatorcontrib>Aust, Duncan T., PhD</creatorcontrib><creatorcontrib>Carson, Dennis L., PhD, DABT</creatorcontrib><creatorcontrib>Seal, Lawton A., PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of infection control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cargill, D. Innes, PhD</au><au>Roche, Eric D., PhD</au><au>Van Der Kar, Catherine A., BS</au><au>Slade, Herbert B., MD</au><au>Aust, Duncan T., PhD</au><au>Carson, Dennis L., PhD, DABT</au><au>Seal, Lawton A., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a health care personnel handwash with 6-hour persistence</atitle><jtitle>American journal of infection control</jtitle><addtitle>Am J Infect Control</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>39</volume><issue>3</issue><spage>226</spage><epage>234</epage><pages>226-234</pages><issn>0196-6553</issn><eissn>1527-3296</eissn><abstract>Background Health care handwashes/sanitizers help prevent the spread of infection. Many are alcohol-based, providing immediate microbial kill. Few contain persistence factors for residual antimicrobial effects. We conducted multiple studies on Viacydin-Containing Alcohol Sanitizer (VCAS) to evaluate antimicrobial properties and skin friendliness. Methods The potential of VCAS to cause use related skin problems was examined by repeated applications over a 3-week period. Excessive handwashing compared effects of VCAS on the skin barrier with that of other handwash products. Antimicrobial range, immediate kill rates, and resistance development were assessed as was the potential for continued antimicrobial activity over an extended period following product use. Results Our data showed the VCAS formula has broad, rapid antimicrobial efficacy without promoting microbial resistance. VCAS is mild to skin. Antimicrobial persistence testing showed that VCAS remained effective up to 6 hours postapplication. Conclusion VCAS was superior to or at parity with on-market products, exhibited substantial residual effects and persistence up to 6 hours, and was safe and well tolerated. These results provide strong evidence for the value of VCAS to help prevent and eliminate pathogen contamination of the hands.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21458685</pmid><doi>10.1016/j.ajic.2011.02.001</doi><tpages>9</tpages></addata></record> |
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| ispartof | American journal of infection control, 2011-04, Vol.39 (3), p.226-234 |
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| subjects | Adult Alcohols - administration & dosage Alcohols - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents antimicrobial activity Antimicrobial agents antimicrobial persistence Antiseptics Bacterial Load Biological and medical sciences Disease control Disease prevention Disinfectants - administration & dosage Disinfectants - adverse effects Epidemiology. Vaccinations General aspects Hand - microbiology Hand Disinfection - methods hand sanitizers Health care handwash Health Personnel Humans Hygiene Infection Control Infectious Disease Infectious diseases Medical sciences Pathogens Pharmacology. Drug treatments Skin - microbiology Sterilization surgical scrub Time Factors |
| title | Development of a health care personnel handwash with 6-hour persistence |
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