Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice

Abstract The deposition of amyloid β protein (Aβ) is a consistent pathological hallmark of Alzheimer's disease (AD) brains. Therefore, inhibition of Aβ aggregation in the brain is an attractive therapeutic and preventive strategy in the development of disease-modifying drugs for AD. An in vitro...

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Veröffentlicht in:	Neuroscience 2011-04, Vol.180, p.305-313
Hauptverfasser:	Fujiwara, H, Takayama, S, Iwasaki, K, Tabuchi, M, Yamaguchi, T, Sekiguchi, K, Ikarashi, Y, Kudo, Y, Kase, Y, Arai, H, Yaegashi, N
Format:	Artikel
Sprache:	eng
Schlagworte:	aggression Alzheimer Disease - complications Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - drug effects Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics amyloid β proteins Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Drugs, Chinese Herbal Fundamental and applied biological sciences. Psychology Interpersonal Relations Japan Male Medical sciences Medicine, East Asian Traditional Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - metabolism Mice Mice, Transgenic Neurology Neuroprotective Agents - pharmacology Phytotherapy Plant Extracts - pharmacology Plants, Medicinal traditional medicine Uncaria hook Vertebrates: nervous system and sense organs yokukansan
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