Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques

A comprehensive overview is presented of currently known phase I metabolites of tamoxifen consisting of their systematic name and molecular structure. Reference standards are utilized to elucidate the MS n fragmentation patterns of these metabolites using a linear ion trap mass spectrometer. UV-abso...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2011-06, Vol.55 (3), p.518-526
Hauptverfasser:	Teunissen, S.F., Rosing, H., Seoane, M. Dominguez, Brunsveld, L., Schellens, J.H.M., Schinkel, A.H., Beijnen, J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - blood Antineoplastic Agents, Hormonal - metabolism Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - drug therapy Chromatography, High Pressure Liquid - methods Female Fragmentation Fundamental and applied biological sciences. Psychology General pharmacology Humans Identification Liquid chromatography Mass spectrometry Medical sciences Metabolic Detoxication, Phase I Metabolites Molecular Structure Pharmacology. Drug treatments Quinones - administration & dosage Quinones - blood Quinones - metabolism Tamoxifen Tamoxifen - administration & dosage Tamoxifen - analogs & derivatives Tamoxifen - blood Tamoxifen - metabolism Tandem Mass Spectrometry UV absorption
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