Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract
Background. This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the...
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| Veröffentlicht in: | Integrative cancer therapies 2011-03, Vol.10 (1), p.77-84 |
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| creator | Verma, Preeti Sharma, Priyanka Parmar, Jyoti Agrawal, Annapurna Goyal, P.K. |
| description | Background. This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver. Results. Radiation exposure resulted in a significant decline (P < .001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls. Conclusion. From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice. |
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This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver. Results. Radiation exposure resulted in a significant decline (P < .001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls. Conclusion. From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice.</description><identifier>ISSN: 1534-7354</identifier><identifier>EISSN: 1552-695X</identifier><identifier>DOI: 10.1177/1534735410375098</identifier><identifier>PMID: 20702497</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Drugs, Chinese Herbal - pharmacology ; Erythrocytes - drug effects ; Erythrocytes - radiation effects ; Gamma Rays ; Glutathione - blood ; Glutathione - metabolism ; Hematocrit ; Hematologic Diseases - etiology ; Hematologic Diseases - prevention & control ; Hemoglobins - metabolism ; Hemoglobins - radiation effects ; Lipid Peroxidation - drug effects ; Lipid Peroxidation - radiation effects ; Liver - metabolism ; Liver - radiation effects ; Male ; Mice ; Radiation Dosage ; Radiation Injuries, Experimental - blood ; Radiation Injuries, Experimental - prevention & control ; Radiation-Protective Agents - pharmacology</subject><ispartof>Integrative cancer therapies, 2011-03, Vol.10 (1), p.77-84</ispartof><rights>The Author(s) 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-6d4baefc6549b1eb6a8f0a69c67839baaaafabe20c3d3663e880af1e073908853</citedby><cites>FETCH-LOGICAL-c378t-6d4baefc6549b1eb6a8f0a69c67839baaaafabe20c3d3663e880af1e073908853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1534735410375098$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1534735410375098$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,860,21946,27832,27903,27904,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1534735410375098?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20702497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verma, Preeti</creatorcontrib><creatorcontrib>Sharma, Priyanka</creatorcontrib><creatorcontrib>Parmar, Jyoti</creatorcontrib><creatorcontrib>Agrawal, Annapurna</creatorcontrib><creatorcontrib>Goyal, P.K.</creatorcontrib><title>Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract</title><title>Integrative cancer therapies</title><addtitle>Integr Cancer Ther</addtitle><description>Background. This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver. Results. Radiation exposure resulted in a significant decline (P < .001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls. Conclusion. From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice.</description><subject>Animals</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - radiation effects</subject><subject>Gamma Rays</subject><subject>Glutathione - blood</subject><subject>Glutathione - metabolism</subject><subject>Hematocrit</subject><subject>Hematologic Diseases - etiology</subject><subject>Hematologic Diseases - prevention & control</subject><subject>Hemoglobins - metabolism</subject><subject>Hemoglobins - radiation effects</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipid Peroxidation - radiation effects</subject><subject>Liver - metabolism</subject><subject>Liver - radiation effects</subject><subject>Male</subject><subject>Mice</subject><subject>Radiation Dosage</subject><subject>Radiation Injuries, Experimental - blood</subject><subject>Radiation Injuries, Experimental - prevention & control</subject><subject>Radiation-Protective Agents - pharmacology</subject><issn>1534-7354</issn><issn>1552-695X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UE1LxDAQDaL4ffckuXmqJk3z0eMq6gqK4gd4K9N0ukbaRJsW3X9vd1c9CM5l5s2892AeIQecHXOu9QmXItNCZpwJLVlu1sg2lzJNVC6f1xezyJLFfYvsxPjKWMqZkptkK2WapVmut8l80mLjQge9C56Gmt5D5ZYgufLVYLGiU2yhD02YOQsNBV_RUxfsC7ZLPGl6XKkjdZ4-fLgYx2XpfKA3ziIt5_QOPHzSmfMR_Yyef_Yd2H6PbNTQRNz_7rvk6eL88WyaXN9eXp1NrhMrtOkTVWUlYG2VzPKSY6nA1AxUbpU2Ii9hrBpKTJkVlVBKoDEMao5Mi5wZI8UuOVr5vnXhfcDYF62LFpsGPIYhFkYxbnQq-chkK6btQowd1sVb51ro5gVnxSLv4m_eo-Tw23woW6x-BT8Bj4RkRYgww-I1DJ0fn_3f8Au7a4l5</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Verma, Preeti</creator><creator>Sharma, Priyanka</creator><creator>Parmar, Jyoti</creator><creator>Agrawal, Annapurna</creator><creator>Goyal, P.K.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract</title><author>Verma, Preeti ; Sharma, Priyanka ; Parmar, Jyoti ; Agrawal, Annapurna ; Goyal, P.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-6d4baefc6549b1eb6a8f0a69c67839baaaafabe20c3d3663e880af1e073908853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - radiation effects</topic><topic>Gamma Rays</topic><topic>Glutathione - blood</topic><topic>Glutathione - metabolism</topic><topic>Hematocrit</topic><topic>Hematologic Diseases - etiology</topic><topic>Hematologic Diseases - prevention & control</topic><topic>Hemoglobins - metabolism</topic><topic>Hemoglobins - radiation effects</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipid Peroxidation - radiation effects</topic><topic>Liver - metabolism</topic><topic>Liver - radiation effects</topic><topic>Male</topic><topic>Mice</topic><topic>Radiation Dosage</topic><topic>Radiation Injuries, Experimental - blood</topic><topic>Radiation Injuries, Experimental - prevention & control</topic><topic>Radiation-Protective Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verma, Preeti</creatorcontrib><creatorcontrib>Sharma, Priyanka</creatorcontrib><creatorcontrib>Parmar, Jyoti</creatorcontrib><creatorcontrib>Agrawal, Annapurna</creatorcontrib><creatorcontrib>Goyal, P.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Integrative cancer therapies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Verma, Preeti</au><au>Sharma, Priyanka</au><au>Parmar, Jyoti</au><au>Agrawal, Annapurna</au><au>Goyal, P.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract</atitle><jtitle>Integrative cancer therapies</jtitle><addtitle>Integr Cancer Ther</addtitle><date>2011-03</date><risdate>2011</risdate><volume>10</volume><issue>1</issue><spage>77</spage><epage>84</epage><pages>77-84</pages><issn>1534-7354</issn><eissn>1552-695X</eissn><abstract>Background. This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver. Results. Radiation exposure resulted in a significant decline (P < .001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls. Conclusion. From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>20702497</pmid><doi>10.1177/1534735410375098</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Drugs, Chinese Herbal - pharmacology Erythrocytes - drug effects Erythrocytes - radiation effects Gamma Rays Glutathione - blood Glutathione - metabolism Hematocrit Hematologic Diseases - etiology Hematologic Diseases - prevention & control Hemoglobins - metabolism Hemoglobins - radiation effects Lipid Peroxidation - drug effects Lipid Peroxidation - radiation effects Liver - metabolism Liver - radiation effects Male Mice Radiation Dosage Radiation Injuries, Experimental - blood Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - pharmacology |
| title | Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract |
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