Facilitated temporal summation of pain at spinal level in Parkinson's disease
Background: Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiop...
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| Veröffentlicht in: | Movement disorders 2011-02, Vol.26 (3), p.442-448 |
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| creator | Perrotta, Armando Sandrini, Giorgio Serrao, Mariano Buscone, Simona Tassorelli, Cristina Tinazzi, Michele Zangaglia, Roberta Pacchetti, Claudio Bartolo, Michelangelo Pierelli, Francesco Martignoni, Emilia |
| description | Background:
Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms.
Materials and methods:
We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa.
Results:
A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected.
Conclusions:
The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.23458 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_860186137</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>860186137</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5198-25eb963572d8c18718b35766b12ec1e6d067a430df6a712e44f50f9e53cf9c4b3</originalsourceid><addsrcrecordid>eNp90VtrFTEQAOAgij1WH_wDsiBSfdg2k9tmH7X1VKXVikrBl5DNZiE1ezGzq_bfm_acVhD0KWTyzQyTIeQx0H2glB30Le4zLqS-Q1YgOZSayeouWVGtZclByx3yAPGCUgAJ6j7ZYSAUY4quyOnauhDDbGffFrPvpzHZWODS93YO41CMXTHZMBR2LnAKQ36L_oePRQ6d2fQtDDgOe1i0Ab1F_5Dc62xE_2h77pIv69efD9-UJx-O3x6-PCmdhFqXTPqmVlxWrNUOdAW6yRelGmDegVctVZUVnLadslWOCdFJ2tVectfVTjR8l-xt6k5p_L54nE0f0PkY7eDHBY1WFLQCXmX5_L8SdF3x3LrmmT79i16MS8ojXytaS05BZPVio1waEZPvzJRCb9OlAWqutmHyNsz1NrJ9sq24NL1vb-XN92fwbAssOhu7ZAcX8I8TVAtdXTU92LifIfrLf3c0p0efblqXm4yAs_91m5FXZlQeWJrz98fm6_rjK3307syc89_Dk62y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1890953014</pqid></control><display><type>article</type><title>Facilitated temporal summation of pain at spinal level in Parkinson's disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Perrotta, Armando ; Sandrini, Giorgio ; Serrao, Mariano ; Buscone, Simona ; Tassorelli, Cristina ; Tinazzi, Michele ; Zangaglia, Roberta ; Pacchetti, Claudio ; Bartolo, Michelangelo ; Pierelli, Francesco ; Martignoni, Emilia</creator><creatorcontrib>Perrotta, Armando ; Sandrini, Giorgio ; Serrao, Mariano ; Buscone, Simona ; Tassorelli, Cristina ; Tinazzi, Michele ; Zangaglia, Roberta ; Pacchetti, Claudio ; Bartolo, Michelangelo ; Pierelli, Francesco ; Martignoni, Emilia</creatorcontrib><description>Background:
Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms.
Materials and methods:
We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa.
Results:
A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected.
Conclusions:
The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.23458</identifier><identifier>PMID: 21462260</identifier><identifier>CODEN: MOVDEA</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Antiparkinson Agents - therapeutic use ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disability Evaluation ; Female ; Humans ; Levodopa - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Movement disorders ; Neurology ; nociceptive withdrawal reflex ; pain ; Pain - drug therapy ; Pain - etiology ; Pain - pathology ; Pain Measurement ; Pain Threshold - drug effects ; Pain Threshold - physiology ; Parkinson Disease - complications ; Parkinson Disease - drug therapy ; Parkinson's disease ; Physical Stimulation ; Psychophysics - methods ; Reflex - physiology ; Severity of Illness Index ; Spinal Cord - physiopathology ; temporal summation</subject><ispartof>Movement disorders, 2011-02, Vol.26 (3), p.442-448</ispartof><rights>Copyright © 2010 Movement Disorder Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5198-25eb963572d8c18718b35766b12ec1e6d067a430df6a712e44f50f9e53cf9c4b3</citedby><cites>FETCH-LOGICAL-c5198-25eb963572d8c18718b35766b12ec1e6d067a430df6a712e44f50f9e53cf9c4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.23458$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.23458$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24084874$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21462260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perrotta, Armando</creatorcontrib><creatorcontrib>Sandrini, Giorgio</creatorcontrib><creatorcontrib>Serrao, Mariano</creatorcontrib><creatorcontrib>Buscone, Simona</creatorcontrib><creatorcontrib>Tassorelli, Cristina</creatorcontrib><creatorcontrib>Tinazzi, Michele</creatorcontrib><creatorcontrib>Zangaglia, Roberta</creatorcontrib><creatorcontrib>Pacchetti, Claudio</creatorcontrib><creatorcontrib>Bartolo, Michelangelo</creatorcontrib><creatorcontrib>Pierelli, Francesco</creatorcontrib><creatorcontrib>Martignoni, Emilia</creatorcontrib><title>Facilitated temporal summation of pain at spinal level in Parkinson's disease</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>Background:
Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms.
Materials and methods:
We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa.
Results:
A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected.
Conclusions:
The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society</description><subject>Adult</subject><subject>Aged</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Neurology</subject><subject>nociceptive withdrawal reflex</subject><subject>pain</subject><subject>Pain - drug therapy</subject><subject>Pain - etiology</subject><subject>Pain - pathology</subject><subject>Pain Measurement</subject><subject>Pain Threshold - drug effects</subject><subject>Pain Threshold - physiology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson's disease</subject><subject>Physical Stimulation</subject><subject>Psychophysics - methods</subject><subject>Reflex - physiology</subject><subject>Severity of Illness Index</subject><subject>Spinal Cord - physiopathology</subject><subject>temporal summation</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90VtrFTEQAOAgij1WH_wDsiBSfdg2k9tmH7X1VKXVikrBl5DNZiE1ezGzq_bfm_acVhD0KWTyzQyTIeQx0H2glB30Le4zLqS-Q1YgOZSayeouWVGtZclByx3yAPGCUgAJ6j7ZYSAUY4quyOnauhDDbGffFrPvpzHZWODS93YO41CMXTHZMBR2LnAKQ36L_oePRQ6d2fQtDDgOe1i0Ab1F_5Dc62xE_2h77pIv69efD9-UJx-O3x6-PCmdhFqXTPqmVlxWrNUOdAW6yRelGmDegVctVZUVnLadslWOCdFJ2tVectfVTjR8l-xt6k5p_L54nE0f0PkY7eDHBY1WFLQCXmX5_L8SdF3x3LrmmT79i16MS8ojXytaS05BZPVio1waEZPvzJRCb9OlAWqutmHyNsz1NrJ9sq24NL1vb-XN92fwbAssOhu7ZAcX8I8TVAtdXTU92LifIfrLf3c0p0efblqXm4yAs_91m5FXZlQeWJrz98fm6_rjK3307syc89_Dk62y</recordid><startdate>20110215</startdate><enddate>20110215</enddate><creator>Perrotta, Armando</creator><creator>Sandrini, Giorgio</creator><creator>Serrao, Mariano</creator><creator>Buscone, Simona</creator><creator>Tassorelli, Cristina</creator><creator>Tinazzi, Michele</creator><creator>Zangaglia, Roberta</creator><creator>Pacchetti, Claudio</creator><creator>Bartolo, Michelangelo</creator><creator>Pierelli, Francesco</creator><creator>Martignoni, Emilia</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110215</creationdate><title>Facilitated temporal summation of pain at spinal level in Parkinson's disease</title><author>Perrotta, Armando ; Sandrini, Giorgio ; Serrao, Mariano ; Buscone, Simona ; Tassorelli, Cristina ; Tinazzi, Michele ; Zangaglia, Roberta ; Pacchetti, Claudio ; Bartolo, Michelangelo ; Pierelli, Francesco ; Martignoni, Emilia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5198-25eb963572d8c18718b35766b12ec1e6d067a430df6a712e44f50f9e53cf9c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antiparkinson Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Levodopa - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Neurology</topic><topic>nociceptive withdrawal reflex</topic><topic>pain</topic><topic>Pain - drug therapy</topic><topic>Pain - etiology</topic><topic>Pain - pathology</topic><topic>Pain Measurement</topic><topic>Pain Threshold - drug effects</topic><topic>Pain Threshold - physiology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson's disease</topic><topic>Physical Stimulation</topic><topic>Psychophysics - methods</topic><topic>Reflex - physiology</topic><topic>Severity of Illness Index</topic><topic>Spinal Cord - physiopathology</topic><topic>temporal summation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perrotta, Armando</creatorcontrib><creatorcontrib>Sandrini, Giorgio</creatorcontrib><creatorcontrib>Serrao, Mariano</creatorcontrib><creatorcontrib>Buscone, Simona</creatorcontrib><creatorcontrib>Tassorelli, Cristina</creatorcontrib><creatorcontrib>Tinazzi, Michele</creatorcontrib><creatorcontrib>Zangaglia, Roberta</creatorcontrib><creatorcontrib>Pacchetti, Claudio</creatorcontrib><creatorcontrib>Bartolo, Michelangelo</creatorcontrib><creatorcontrib>Pierelli, Francesco</creatorcontrib><creatorcontrib>Martignoni, Emilia</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perrotta, Armando</au><au>Sandrini, Giorgio</au><au>Serrao, Mariano</au><au>Buscone, Simona</au><au>Tassorelli, Cristina</au><au>Tinazzi, Michele</au><au>Zangaglia, Roberta</au><au>Pacchetti, Claudio</au><au>Bartolo, Michelangelo</au><au>Pierelli, Francesco</au><au>Martignoni, Emilia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facilitated temporal summation of pain at spinal level in Parkinson's disease</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. Disord</addtitle><date>2011-02-15</date><risdate>2011</risdate><volume>26</volume><issue>3</issue><spage>442</spage><epage>448</epage><pages>442-448</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><coden>MOVDEA</coden><abstract>Background:
Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms.
Materials and methods:
We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa.
Results:
A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected.
Conclusions:
The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21462260</pmid><doi>10.1002/mds.23458</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Antiparkinson Agents - therapeutic use Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disability Evaluation Female Humans Levodopa - therapeutic use Male Medical sciences Middle Aged Movement disorders Neurology nociceptive withdrawal reflex pain Pain - drug therapy Pain - etiology Pain - pathology Pain Measurement Pain Threshold - drug effects Pain Threshold - physiology Parkinson Disease - complications Parkinson Disease - drug therapy Parkinson's disease Physical Stimulation Psychophysics - methods Reflex - physiology Severity of Illness Index Spinal Cord - physiopathology temporal summation |
| title | Facilitated temporal summation of pain at spinal level in Parkinson's disease |
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