Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy

Pentose phosphate pathway (PPP) represents a potentially 'protective' mechanism in hyperglycaemia due to shunting of glycolytic intermediates into PPP reactions. We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variabilit...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2011-04, Vol.26 (4), p.1229-1236
Hauptverfasser:	PACAL, Lukáš, TOMANDL, Josef, MUZIK, Jan, KANKOVA, Kateřina, SVOJANOVSKY, Jan, KRUSOVA, Darja, STEPANKOVA, Soňa, REHOROVA, Jitka, OLSOVSKY, Jindřich, BELOBRADKOVA, Jana, TANHÄUSEROVA, Veronika, TOMANDLOVA, Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Associated diseases and complications Biological and medical sciences Cross-Sectional Studies Diabetes. Impaired glucose tolerance Diabetic Nephropathies - enzymology Diabetic Nephropathies - genetics Diabetic Nephropathies - mortality Emergency and intensive care: renal failure. Dialysis management Endocrine pancreas. Apud cells (diseases) Endocrinopathies Erythrocytes - enzymology Female Follow-Up Studies Genotype Glucose - metabolism Humans Intensive care medicine Male Medical sciences Middle Aged Pentose Phosphate Pathway Pentosephosphates - metabolism Polymorphism, Single Nucleotide - genetics Survival Rate Thiamine - metabolism Transaldolase - genetics Transketolase - genetics
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