Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System
Magnetic iron oxide nanoparticles (MIONPs) were synthesized in a FeCl 2—NaNO3—NaOH aqueous system under various initial Fe2+/NO- 3 molar ratios (α) and Fe 2+/OH- molar ratios (β) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe 2+/NO- 3 /OH- m...
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| Veröffentlicht in: | Journal of biomaterials applications 2011-03, Vol.25 (7), p.643-661 |
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| container_title | Journal of biomaterials applications |
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| creator | Li, Zhixia Kawashita, Masakazu Araki, Norio Mitsumori, Michihide Hiraoka, Masahiro Doi, Masaaki |
| description | Magnetic iron oxide nanoparticles (MIONPs) were synthesized in a FeCl 2—NaNO3—NaOH aqueous system under various initial Fe2+/NO-
3 molar ratios (α) and Fe 2+/OH- molar ratios (β) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe 2+/NO-
3 /OH- molar ratio of 3 : 1 : 5 led to the formation of magnetic nanoparticles mainly composed of magnetite (Fe3O4) and maghemite (γ-Fe2O3). The 36 nm sized γ-Fe2O3 and 413 nm sized Fe 3O4 were obtained by changing the order in which NaNO 3 was added to a NaOH solution. The in vitro heat generations of the resulting MIONPs in an agar phantom were measured under an alternating magnetic field (100 kHz, 23.9 kA/m). The temperature rise (ΔT) of the agar phantom for the 36 nm sized γFe2O3 was 55°C in the first 140 s, with a concentration of 58 mg Fe/mL. Our results showed that it is possible to prepare MIONPs with high heating efficiencies under optimal conditions using the present method. |
| doi_str_mv | 10.1177/0885328209351136 |
| format | Article |
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3 molar ratios (α) and Fe 2+/OH- molar ratios (β) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe 2+/NO-
3 /OH- molar ratio of 3 : 1 : 5 led to the formation of magnetic nanoparticles mainly composed of magnetite (Fe3O4) and maghemite (γ-Fe2O3). The 36 nm sized γ-Fe2O3 and 413 nm sized Fe 3O4 were obtained by changing the order in which NaNO 3 was added to a NaOH solution. The in vitro heat generations of the resulting MIONPs in an agar phantom were measured under an alternating magnetic field (100 kHz, 23.9 kA/m). The temperature rise (ΔT) of the agar phantom for the 36 nm sized γFe2O3 was 55°C in the first 140 s, with a concentration of 58 mg Fe/mL. Our results showed that it is possible to prepare MIONPs with high heating efficiencies under optimal conditions using the present method.</description><identifier>ISSN: 0885-3282</identifier><identifier>EISSN: 1530-8022</identifier><identifier>DOI: 10.1177/0885328209351136</identifier><identifier>PMID: 20207773</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Ferric Compounds - chemistry ; Ferric Compounds - therapeutic use ; Humans ; Hyperthermia, Induced - methods ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanoparticles - ultrastructure ; Neoplasms - therapy ; Oxidation-Reduction</subject><ispartof>Journal of biomaterials applications, 2011-03, Vol.25 (7), p.643-661</ispartof><rights>The Author(s), 2010.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0885328209351136$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0885328209351136$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20207773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhixia</creatorcontrib><creatorcontrib>Kawashita, Masakazu</creatorcontrib><creatorcontrib>Araki, Norio</creatorcontrib><creatorcontrib>Mitsumori, Michihide</creatorcontrib><creatorcontrib>Hiraoka, Masahiro</creatorcontrib><creatorcontrib>Doi, Masaaki</creatorcontrib><title>Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System</title><title>Journal of biomaterials applications</title><addtitle>J Biomater Appl</addtitle><description>Magnetic iron oxide nanoparticles (MIONPs) were synthesized in a FeCl 2—NaNO3—NaOH aqueous system under various initial Fe2+/NO-
3 molar ratios (α) and Fe 2+/OH- molar ratios (β) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe 2+/NO-
3 /OH- molar ratio of 3 : 1 : 5 led to the formation of magnetic nanoparticles mainly composed of magnetite (Fe3O4) and maghemite (γ-Fe2O3). The 36 nm sized γ-Fe2O3 and 413 nm sized Fe 3O4 were obtained by changing the order in which NaNO 3 was added to a NaOH solution. The in vitro heat generations of the resulting MIONPs in an agar phantom were measured under an alternating magnetic field (100 kHz, 23.9 kA/m). The temperature rise (ΔT) of the agar phantom for the 36 nm sized γFe2O3 was 55°C in the first 140 s, with a concentration of 58 mg Fe/mL. Our results showed that it is possible to prepare MIONPs with high heating efficiencies under optimal conditions using the present method.</description><subject>Ferric Compounds - chemistry</subject><subject>Ferric Compounds - therapeutic use</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - therapeutic use</subject><subject>Nanoparticles - ultrastructure</subject><subject>Neoplasms - therapy</subject><subject>Oxidation-Reduction</subject><issn>0885-3282</issn><issn>1530-8022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkb1PwzAQxS0EoqWwMyFvTAF_JLYzVhGllUqDBMyRnVxKqnxhJxL973FEWVjupHu_Oz3dQ-iWkgdKpXwkSkWcKUZiHlHKxRma04iTQBHGztF8koNJn6Er5w6EkCgOxSWaMcKIlJLPUf9qoddWD1XX4q7EL3rfwlDleGP9IP2uCsA73Xae8dMaHC47i9fHHuzwCbap9LSV6DYHi6sWa7yCpGbBTu9S7mu6xsuvEbrR4bejG6C5Rhelrh3cnPoCfaye3pN1sE2fN8lyGxw4DYeAalMYGfKQChYqlhcQchEKMHlJJJNGxBQYoyoqChUrnhehEZooKmNqWGE0X6D737u97bwBN2RN5XKoa91ObjIlCFWcRNSTdydyNA0UWW-rRttj9vckDwS_gNN7yA7daFvvPKMkm0LI_ofAfwAnu3UR</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Li, Zhixia</creator><creator>Kawashita, Masakazu</creator><creator>Araki, Norio</creator><creator>Mitsumori, Michihide</creator><creator>Hiraoka, Masahiro</creator><creator>Doi, Masaaki</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System</title><author>Li, Zhixia ; Kawashita, Masakazu ; Araki, Norio ; Mitsumori, Michihide ; Hiraoka, Masahiro ; Doi, Masaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j314t-1abdb7434162482cde43646ebcf0727b691e22185dd8983cd4b6a081791b2dba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Ferric Compounds - chemistry</topic><topic>Ferric Compounds - therapeutic use</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - therapeutic use</topic><topic>Nanoparticles - ultrastructure</topic><topic>Neoplasms - therapy</topic><topic>Oxidation-Reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhixia</creatorcontrib><creatorcontrib>Kawashita, Masakazu</creatorcontrib><creatorcontrib>Araki, Norio</creatorcontrib><creatorcontrib>Mitsumori, Michihide</creatorcontrib><creatorcontrib>Hiraoka, Masahiro</creatorcontrib><creatorcontrib>Doi, Masaaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomaterials applications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhixia</au><au>Kawashita, Masakazu</au><au>Araki, Norio</au><au>Mitsumori, Michihide</au><au>Hiraoka, Masahiro</au><au>Doi, Masaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System</atitle><jtitle>Journal of biomaterials applications</jtitle><addtitle>J Biomater Appl</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>25</volume><issue>7</issue><spage>643</spage><epage>661</epage><pages>643-661</pages><issn>0885-3282</issn><eissn>1530-8022</eissn><abstract>Magnetic iron oxide nanoparticles (MIONPs) were synthesized in a FeCl 2—NaNO3—NaOH aqueous system under various initial Fe2+/NO-
3 molar ratios (α) and Fe 2+/OH- molar ratios (β) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe 2+/NO-
3 /OH- molar ratio of 3 : 1 : 5 led to the formation of magnetic nanoparticles mainly composed of magnetite (Fe3O4) and maghemite (γ-Fe2O3). The 36 nm sized γ-Fe2O3 and 413 nm sized Fe 3O4 were obtained by changing the order in which NaNO 3 was added to a NaOH solution. The in vitro heat generations of the resulting MIONPs in an agar phantom were measured under an alternating magnetic field (100 kHz, 23.9 kA/m). The temperature rise (ΔT) of the agar phantom for the 36 nm sized γFe2O3 was 55°C in the first 140 s, with a concentration of 58 mg Fe/mL. Our results showed that it is possible to prepare MIONPs with high heating efficiencies under optimal conditions using the present method.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>20207773</pmid><doi>10.1177/0885328209351136</doi><tpages>19</tpages></addata></record> |
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| subjects | Ferric Compounds - chemistry Ferric Compounds - therapeutic use Humans Hyperthermia, Induced - methods Nanoparticles - chemistry Nanoparticles - therapeutic use Nanoparticles - ultrastructure Neoplasms - therapy Oxidation-Reduction |
| title | Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System |
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