Effects of local infiltration of insulin around titanium implants in diabetic rats
Abstract In patients with type 2 diabetes mellitus (DM) there is poorer quality osseointegration than in other patients, and the success of oral implants is less. The aim of the present study was to investigate the influence of local infiltration of insulin at the implant–bone interface after implan...
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| Veröffentlicht in: | British journal of oral & maxillofacial surgery 2011-04, Vol.49 (3), p.225-229 |
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| creator | Wang, Baogang Song, Yingliang Wang, Feng Li, Dehua Zhang, Hepeng Ma, Aijie Huang, Na |
| description | Abstract In patients with type 2 diabetes mellitus (DM) there is poorer quality osseointegration than in other patients, and the success of oral implants is less. The aim of the present study was to investigate the influence of local infiltration of insulin at the implant–bone interface after implantation in diabetic rats. We used GK rats (8-week-old Goto-Kakizaki Wistar rats, n = 20) in a newly established model of type 2 DM, and Sprague–Dawley rats were used as controls ( n = 10). GK rats were divided into two groups: those with DM alone and those with DM given insulin (INS) ( n = 10 in each group). The INS group was given controlled-release insulin at the implant–bone interface. Rats were killed at 2 and 6 weeks after implantation. We evaluated bone–implant contact and bony volume in all rats. Implant–bone contact, osteoid and osteogenic volume, and the amount of newly formed bone in the DM group were significantly less than in the control ( p < 0.05) and INS ( p < 0.01) groups. Implant–bone contact in the INS group was less than that in the control group, but the amount of newly formed bone was greater. In conclusion, we suggest that although the implant–bone contact in the INS group did not reach the control level, direct infiltration of insulin could improve implant–bone contact. Local infiltration of insulin at the implant–bone interface may have important clinical implications by naturally improving the success of oral implantation in diabetic rats. |
| doi_str_mv | 10.1016/j.bjoms.2010.03.006 |
| format | Article |
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The aim of the present study was to investigate the influence of local infiltration of insulin at the implant–bone interface after implantation in diabetic rats. We used GK rats (8-week-old Goto-Kakizaki Wistar rats, n = 20) in a newly established model of type 2 DM, and Sprague–Dawley rats were used as controls ( n = 10). GK rats were divided into two groups: those with DM alone and those with DM given insulin (INS) ( n = 10 in each group). The INS group was given controlled-release insulin at the implant–bone interface. Rats were killed at 2 and 6 weeks after implantation. We evaluated bone–implant contact and bony volume in all rats. Implant–bone contact, osteoid and osteogenic volume, and the amount of newly formed bone in the DM group were significantly less than in the control ( p < 0.05) and INS ( p < 0.01) groups. Implant–bone contact in the INS group was less than that in the control group, but the amount of newly formed bone was greater. In conclusion, we suggest that although the implant–bone contact in the INS group did not reach the control level, direct infiltration of insulin could improve implant–bone contact. Local infiltration of insulin at the implant–bone interface may have important clinical implications by naturally improving the success of oral implantation in diabetic rats.</description><identifier>ISSN: 0266-4356</identifier><identifier>EISSN: 1532-1940</identifier><identifier>DOI: 10.1016/j.bjoms.2010.03.006</identifier><identifier>PMID: 20400213</identifier><identifier>CODEN: BJOSEY</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Dental Implantation, Endosseous ; Dental Implants ; Dentistry ; Diabetes mellitus ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; GK rats ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; Implants, Experimental ; Insulin ; Insulin - administration & dosage ; Insulin - pharmacology ; Male ; Medical sciences ; Microspheres ; Osseointegration ; Osseointegration - drug effects ; Otorhinolaryngology. Stomatology ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Surgery ; Tibia - surgery ; Titanium ; Titanium implants</subject><ispartof>British journal of oral & maxillofacial surgery, 2011-04, Vol.49 (3), p.225-229</ispartof><rights>The British Association of Oral and Maxillofacial Surgeons</rights><rights>2010 The British Association of Oral and Maxillofacial Surgeons</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-590c117744e4ddbba01dfdf868bce8cefe158fbb4d0a2f43b31b03a14da924113</citedby><cites>FETCH-LOGICAL-c509t-590c117744e4ddbba01dfdf868bce8cefe158fbb4d0a2f43b31b03a14da924113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0266435610000847$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23986195$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20400213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Baogang</creatorcontrib><creatorcontrib>Song, Yingliang</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Li, Dehua</creatorcontrib><creatorcontrib>Zhang, Hepeng</creatorcontrib><creatorcontrib>Ma, Aijie</creatorcontrib><creatorcontrib>Huang, Na</creatorcontrib><title>Effects of local infiltration of insulin around titanium implants in diabetic rats</title><title>British journal of oral & maxillofacial surgery</title><addtitle>Br J Oral Maxillofac Surg</addtitle><description>Abstract In patients with type 2 diabetes mellitus (DM) there is poorer quality osseointegration than in other patients, and the success of oral implants is less. The aim of the present study was to investigate the influence of local infiltration of insulin at the implant–bone interface after implantation in diabetic rats. We used GK rats (8-week-old Goto-Kakizaki Wistar rats, n = 20) in a newly established model of type 2 DM, and Sprague–Dawley rats were used as controls ( n = 10). GK rats were divided into two groups: those with DM alone and those with DM given insulin (INS) ( n = 10 in each group). The INS group was given controlled-release insulin at the implant–bone interface. Rats were killed at 2 and 6 weeks after implantation. We evaluated bone–implant contact and bony volume in all rats. Implant–bone contact, osteoid and osteogenic volume, and the amount of newly formed bone in the DM group were significantly less than in the control ( p < 0.05) and INS ( p < 0.01) groups. Implant–bone contact in the INS group was less than that in the control group, but the amount of newly formed bone was greater. In conclusion, we suggest that although the implant–bone contact in the INS group did not reach the control level, direct infiltration of insulin could improve implant–bone contact. Local infiltration of insulin at the implant–bone interface may have important clinical implications by naturally improving the success of oral implantation in diabetic rats.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dental Implantation, Endosseous</subject><subject>Dental Implants</subject><subject>Dentistry</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>GK rats</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Implants, Experimental</subject><subject>Insulin</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Osseointegration</subject><subject>Osseointegration - drug effects</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rats, Wistar</subject><subject>Surgery</subject><subject>Tibia - surgery</subject><subject>Titanium</subject><subject>Titanium implants</subject><issn>0266-4356</issn><issn>1532-1940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMoznX0FwjSjbjq9Zwk7U0XCjKMozAg-LEO-YTUNrkmrTD_3tR7dcCNq8DJ8yaH5yXkOcIeAfvX416PaS57CnUCbA_QPyA77BhtceDwkOyA9n3LWddfkCeljADQUewekwsKHIAi25HP1947s5Qm-WZKRk1NiD5MS1ZLSHGbhljWKcRG5bRG2yxhUTGscxPm46RiTdY7G5R2SzBNjZWn5JFXU3HPzucl-fb--uvVh_b2083Hq3e3relgWNpuAIN4OHDuuLVaK0DrrRe90MYJ47zDTnituQVFPWeaoQamkFs1UI7ILsmr07vHnH6srixyDsW4qW7l0lqk6AEPQiBUkp1Ik1Mp2Xl5zGFW-U4iyM2lHOVvl3JzKYHJ6rKmXpzfX_Xs7N_MH3kVeHkGVKnmfFbRhHLPsUH0OHSVe3PiXLXxM7gsiwkuGmdDru6lTeE_i7z9J29qIaF--d3duTKmNccqWqIsVIL8stW-tY61cBD8wH4BprWo0Q</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Wang, Baogang</creator><creator>Song, Yingliang</creator><creator>Wang, Feng</creator><creator>Li, Dehua</creator><creator>Zhang, Hepeng</creator><creator>Ma, Aijie</creator><creator>Huang, Na</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Effects of local infiltration of insulin around titanium implants in diabetic rats</title><author>Wang, Baogang ; Song, Yingliang ; Wang, Feng ; Li, Dehua ; Zhang, Hepeng ; Ma, Aijie ; Huang, Na</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-590c117744e4ddbba01dfdf868bce8cefe158fbb4d0a2f43b31b03a14da924113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dental Implantation, Endosseous</topic><topic>Dental Implants</topic><topic>Dentistry</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>GK rats</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Implants, Experimental</topic><topic>Insulin</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>Osseointegration</topic><topic>Osseointegration - drug effects</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rats, Wistar</topic><topic>Surgery</topic><topic>Tibia - surgery</topic><topic>Titanium</topic><topic>Titanium implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Baogang</creatorcontrib><creatorcontrib>Song, Yingliang</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Li, Dehua</creatorcontrib><creatorcontrib>Zhang, Hepeng</creatorcontrib><creatorcontrib>Ma, Aijie</creatorcontrib><creatorcontrib>Huang, Na</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of oral & maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Baogang</au><au>Song, Yingliang</au><au>Wang, Feng</au><au>Li, Dehua</au><au>Zhang, Hepeng</au><au>Ma, Aijie</au><au>Huang, Na</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of local infiltration of insulin around titanium implants in diabetic rats</atitle><jtitle>British journal of oral & maxillofacial surgery</jtitle><addtitle>Br J Oral Maxillofac Surg</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>49</volume><issue>3</issue><spage>225</spage><epage>229</epage><pages>225-229</pages><issn>0266-4356</issn><eissn>1532-1940</eissn><coden>BJOSEY</coden><abstract>Abstract In patients with type 2 diabetes mellitus (DM) there is poorer quality osseointegration than in other patients, and the success of oral implants is less. The aim of the present study was to investigate the influence of local infiltration of insulin at the implant–bone interface after implantation in diabetic rats. We used GK rats (8-week-old Goto-Kakizaki Wistar rats, n = 20) in a newly established model of type 2 DM, and Sprague–Dawley rats were used as controls ( n = 10). GK rats were divided into two groups: those with DM alone and those with DM given insulin (INS) ( n = 10 in each group). The INS group was given controlled-release insulin at the implant–bone interface. Rats were killed at 2 and 6 weeks after implantation. We evaluated bone–implant contact and bony volume in all rats. Implant–bone contact, osteoid and osteogenic volume, and the amount of newly formed bone in the DM group were significantly less than in the control ( p < 0.05) and INS ( p < 0.01) groups. Implant–bone contact in the INS group was less than that in the control group, but the amount of newly formed bone was greater. In conclusion, we suggest that although the implant–bone contact in the INS group did not reach the control level, direct infiltration of insulin could improve implant–bone contact. Local infiltration of insulin at the implant–bone interface may have important clinical implications by naturally improving the success of oral implantation in diabetic rats.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20400213</pmid><doi>10.1016/j.bjoms.2010.03.006</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of oral & maxillofacial surgery, 2011-04, Vol.49 (3), p.225-229 |
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| subjects | Animals Biological and medical sciences Dental Implantation, Endosseous Dental Implants Dentistry Diabetes mellitus Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance GK rats Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Implants, Experimental Insulin Insulin - administration & dosage Insulin - pharmacology Male Medical sciences Microspheres Osseointegration Osseointegration - drug effects Otorhinolaryngology. Stomatology Rats Rats, Sprague-Dawley Rats, Wistar Surgery Tibia - surgery Titanium Titanium implants |
| title | Effects of local infiltration of insulin around titanium implants in diabetic rats |
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