Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer's disease (AD)? Findings from a cross-sectional study
Abstract The authors performed a cross-sectional study to examine the relationship between specific cognitive domains and behavioral and psychological symptoms in dementia (BPSD) in 125 patients with probable AD. Cognitive deficits were evaluated with the mini mental state examination (MMSE), trail-...
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| Veröffentlicht in: | Archives of gerontology and geriatrics 2011-05, Vol.52 (3), p.264-269 |
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| container_title | Archives of gerontology and geriatrics |
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| creator | García-Alberca, José María Lara, José Pablo Berthier, Marcelo Luis Cruz, Belén Barbancho, Miguel Ángel Green, Cristina González-Barón, Salvador |
| description | Abstract The authors performed a cross-sectional study to examine the relationship between specific cognitive domains and behavioral and psychological symptoms in dementia (BPSD) in 125 patients with probable AD. Cognitive deficits were evaluated with the mini mental state examination (MMSE), trail-making test (TMT), Rey auditory verbal learning test (RAVLT), and semantic fluency test (SFT) and phonemic fluency test (PhFT), whereas the neuropsychiatric inventory (NPI) was used to rate BPSD. Patients’ performance in cognitive tests significantly correlated with total NPI scores ( p < 0.0001). After controlling for demographic and clinical characteristics, cognitive impairments in memory, executive function, and language (RAVLT, TMT, PhFT, SFT) importantly estimated total NPI scores ( p < 0.001, multivariate regression models). These findings suggest that the evaluation of cognitive domains may have a predictive value for the occurrence of BPSD. |
| doi_str_mv | 10.1016/j.archger.2010.05.004 |
| format | Article |
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Findings from a cross-sectional study</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>García-Alberca, José María ; Lara, José Pablo ; Berthier, Marcelo Luis ; Cruz, Belén ; Barbancho, Miguel Ángel ; Green, Cristina ; González-Barón, Salvador</creator><creatorcontrib>García-Alberca, José María ; Lara, José Pablo ; Berthier, Marcelo Luis ; Cruz, Belén ; Barbancho, Miguel Ángel ; Green, Cristina ; González-Barón, Salvador</creatorcontrib><description>Abstract The authors performed a cross-sectional study to examine the relationship between specific cognitive domains and behavioral and psychological symptoms in dementia (BPSD) in 125 patients with probable AD. Cognitive deficits were evaluated with the mini mental state examination (MMSE), trail-making test (TMT), Rey auditory verbal learning test (RAVLT), and semantic fluency test (SFT) and phonemic fluency test (PhFT), whereas the neuropsychiatric inventory (NPI) was used to rate BPSD. Patients’ performance in cognitive tests significantly correlated with total NPI scores ( p < 0.0001). After controlling for demographic and clinical characteristics, cognitive impairments in memory, executive function, and language (RAVLT, TMT, PhFT, SFT) importantly estimated total NPI scores ( p < 0.001, multivariate regression models). These findings suggest that the evaluation of cognitive domains may have a predictive value for the occurrence of BPSD.</description><identifier>ISSN: 0167-4943</identifier><identifier>EISSN: 1872-6976</identifier><identifier>DOI: 10.1016/j.archger.2010.05.004</identifier><identifier>PMID: 20570375</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - epidemiology ; Alzheimer Disease - psychology ; Alzheimer's disease ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Cognition Disorders - psychology ; Cognitive impairment ; Cross-Sectional Studies ; Executive Function ; Female ; Fluency ; Humans ; Internal Medicine ; Language Disorders - diagnosis ; Language Disorders - epidemiology ; Language Disorders - psychology ; Language functions ; Male ; Memory ; Memory Disorders - diagnosis ; Memory Disorders - epidemiology ; Memory Disorders - psychology ; Memory function ; Middle Aged ; Minimental State Examination ; Neuropsychiatric symptoms ; Neuropsychological Tests ; Prevalence</subject><ispartof>Archives of gerontology and geriatrics, 2011-05, Vol.52 (3), p.264-269</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-3fc13439c55b10899125013650db622c3c6efc8b9b61fc82312a45f70bae62353</citedby><cites>FETCH-LOGICAL-c584t-3fc13439c55b10899125013650db622c3c6efc8b9b61fc82312a45f70bae62353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archger.2010.05.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,30999,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20570375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Alberca, José María</creatorcontrib><creatorcontrib>Lara, José Pablo</creatorcontrib><creatorcontrib>Berthier, Marcelo Luis</creatorcontrib><creatorcontrib>Cruz, Belén</creatorcontrib><creatorcontrib>Barbancho, Miguel Ángel</creatorcontrib><creatorcontrib>Green, Cristina</creatorcontrib><creatorcontrib>González-Barón, Salvador</creatorcontrib><title>Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer's disease (AD)? Findings from a cross-sectional study</title><title>Archives of gerontology and geriatrics</title><addtitle>Arch Gerontol Geriatr</addtitle><description>Abstract The authors performed a cross-sectional study to examine the relationship between specific cognitive domains and behavioral and psychological symptoms in dementia (BPSD) in 125 patients with probable AD. Cognitive deficits were evaluated with the mini mental state examination (MMSE), trail-making test (TMT), Rey auditory verbal learning test (RAVLT), and semantic fluency test (SFT) and phonemic fluency test (PhFT), whereas the neuropsychiatric inventory (NPI) was used to rate BPSD. Patients’ performance in cognitive tests significantly correlated with total NPI scores ( p < 0.0001). After controlling for demographic and clinical characteristics, cognitive impairments in memory, executive function, and language (RAVLT, TMT, PhFT, SFT) importantly estimated total NPI scores ( p < 0.001, multivariate regression models). These findings suggest that the evaluation of cognitive domains may have a predictive value for the occurrence of BPSD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - psychology</subject><subject>Cognitive impairment</subject><subject>Cross-Sectional Studies</subject><subject>Executive Function</subject><subject>Female</subject><subject>Fluency</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Language Disorders - diagnosis</subject><subject>Language Disorders - epidemiology</subject><subject>Language Disorders - psychology</subject><subject>Language functions</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - epidemiology</subject><subject>Memory Disorders - psychology</subject><subject>Memory function</subject><subject>Middle Aged</subject><subject>Minimental State Examination</subject><subject>Neuropsychiatric symptoms</subject><subject>Neuropsychological Tests</subject><subject>Prevalence</subject><issn>0167-4943</issn><issn>1872-6976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNks1u1DAUhSMEoqXwCCDvWiQy-Cd24g3VaKCAVIkFsLYc52bGQ-ykdlIRXoZXxekMLFhQNr6S9d1z7XtOlj0neEUwEa_3Kx3MbgthRXG6w3yFcfEgOyVVSXMhS_EwO01cmReyYCfZkxj3OBGYisfZCcW8xKzkp9nPjfbIukHb4MCPyHrkwPVhfoU67beT3gLSvkHwHcw02ltA7eTNaHsf0RCgsWZEHqbQD3E2O6vHYA2KsxvG3sVFbd392IF1EM4jamwEHQFdrN--vERX1jfWbyNqQ--QRib0MeYR7tR1h-I4NfPT7FGruwjPjvUs-3r17svmQ3796f3Hzfo6N7wqxpy1hrCCScN5TXAlJaEcEyY4bmpBqWFGQGuqWtaCpEoZobrgbYlrDYIyzs6y84PuEPqbCeKonI0GurQE6KeoKoFJWZVEJvLinyThBZGSUir-D63SWd6PpvFSMMyXp_IDerewAK0agnU6zAlaOKH26pgNtWRDYa6S86nvxXHEVDto_nT9DkMCLg8ApEXf2tQejQVvksshuaKa3t474s1fCqaz3hrdfYMZ4r6fQnI2_UZFqrD6vAR0ySdJ0SRUSvYLk4PitQ</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>García-Alberca, José María</creator><creator>Lara, José Pablo</creator><creator>Berthier, Marcelo Luis</creator><creator>Cruz, Belén</creator><creator>Barbancho, Miguel Ángel</creator><creator>Green, Cristina</creator><creator>González-Barón, Salvador</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7QJ</scope><scope>7T9</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer's disease (AD)? Findings from a cross-sectional study</title><author>García-Alberca, José María ; Lara, José Pablo ; Berthier, Marcelo Luis ; Cruz, Belén ; Barbancho, Miguel Ángel ; Green, Cristina ; González-Barón, Salvador</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-3fc13439c55b10899125013650db622c3c6efc8b9b61fc82312a45f70bae62353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - psychology</topic><topic>Cognitive impairment</topic><topic>Cross-Sectional Studies</topic><topic>Executive Function</topic><topic>Female</topic><topic>Fluency</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Language Disorders - diagnosis</topic><topic>Language Disorders - epidemiology</topic><topic>Language Disorders - psychology</topic><topic>Language functions</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - epidemiology</topic><topic>Memory Disorders - psychology</topic><topic>Memory function</topic><topic>Middle Aged</topic><topic>Minimental State Examination</topic><topic>Neuropsychiatric symptoms</topic><topic>Neuropsychological Tests</topic><topic>Prevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Alberca, José María</creatorcontrib><creatorcontrib>Lara, José Pablo</creatorcontrib><creatorcontrib>Berthier, Marcelo Luis</creatorcontrib><creatorcontrib>Cruz, Belén</creatorcontrib><creatorcontrib>Barbancho, Miguel Ángel</creatorcontrib><creatorcontrib>Green, Cristina</creatorcontrib><creatorcontrib>González-Barón, Salvador</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gerontology and geriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Alberca, José María</au><au>Lara, José Pablo</au><au>Berthier, Marcelo Luis</au><au>Cruz, Belén</au><au>Barbancho, Miguel Ángel</au><au>Green, Cristina</au><au>González-Barón, Salvador</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer's disease (AD)? Findings from a cross-sectional study</atitle><jtitle>Archives of gerontology and geriatrics</jtitle><addtitle>Arch Gerontol Geriatr</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>52</volume><issue>3</issue><spage>264</spage><epage>269</epage><pages>264-269</pages><issn>0167-4943</issn><eissn>1872-6976</eissn><abstract>Abstract The authors performed a cross-sectional study to examine the relationship between specific cognitive domains and behavioral and psychological symptoms in dementia (BPSD) in 125 patients with probable AD. Cognitive deficits were evaluated with the mini mental state examination (MMSE), trail-making test (TMT), Rey auditory verbal learning test (RAVLT), and semantic fluency test (SFT) and phonemic fluency test (PhFT), whereas the neuropsychiatric inventory (NPI) was used to rate BPSD. Patients’ performance in cognitive tests significantly correlated with total NPI scores ( p < 0.0001). 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| ispartof | Archives of gerontology and geriatrics, 2011-05, Vol.52 (3), p.264-269 |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - psychology Alzheimer's disease Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - psychology Cognitive impairment Cross-Sectional Studies Executive Function Female Fluency Humans Internal Medicine Language Disorders - diagnosis Language Disorders - epidemiology Language Disorders - psychology Language functions Male Memory Memory Disorders - diagnosis Memory Disorders - epidemiology Memory Disorders - psychology Memory function Middle Aged Minimental State Examination Neuropsychiatric symptoms Neuropsychological Tests Prevalence |
| title | Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer's disease (AD)? Findings from a cross-sectional study |
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