Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

Objectives Increasing evidence suggests that oxidative stress may play a key role in joint destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that maintains the cellular defence a...

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Veröffentlicht in:	Annals of the rheumatic diseases 2011-05, Vol.70 (5), p.844-850
Hauptverfasser:	Wruck, Christoph Jan, Fragoulis, Athanassios, Gurzynski, Agata, Brandenburg, Lars-Ove, Kan, Yuet Wai, Chan, Kaimin, Hassenpflug, Joachim, Freitag-Wolf, Sandra, Varoga, Deike, Lippross, Sebastian, Pufe, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Animals Antioxidants Arthritis, Experimental - complications Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Arthritis, Experimental - physiopathology Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - physiopathology Biological and medical sciences Cartilage, Articular - pathology Cartilage, Articular - physiopathology Diseases of the osteoarticular system Enzymes Fractures, Spontaneous - etiology Fractures, Spontaneous - pathology Gene Expression Genes Glutamate-Cysteine Ligase - metabolism Heme Oxygenase-1 - metabolism Inflammatory joint diseases Medical sciences Mice Mice, Knockout NF-E2-Related Factor 2 - deficiency NF-E2-Related Factor 2 - physiology Oxidative stress Oxidative Stress - physiology Pathogenesis Protein expression Proteins Rheumatoid arthritis RNA, Messenger - genetics Rodents Thioredoxins - metabolism Tumor necrosis factor-TNF Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics
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