Linear ubiquitination prevents inflammation and regulates immune signalling

Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex containing HOIL-1 and HOIP (also known as RBCK1 and RNF31, respectively) were implicated in TNF signalling, yet their releva...

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Veröffentlicht in:	Nature (London) 2011-03, Vol.471 (7340), p.591-596
Hauptverfasser:	Gerlach, Björn, Cordier, Stefanie M., Schmukle, Anna C., Emmerich, Christoph H., Rieser, Eva, Haas, Tobias L., Webb, Andrew I., Rickard, James A., Anderton, Holly, Wong, Wendy W.-L., Nachbur, Ueli, Gangoda, Lahiru, Warnken, Uwe, Purcell, Anthony W., Silke, John, Walczak, Henning
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/516 631/80/474/582 692/699/249/2510 Animals Apoptosis Biological and medical sciences Carrier Proteins - chemistry Carrier Proteins - metabolism CD40 Ligand - metabolism Cell Line Cellular signal transduction Dermatitis Disease Fundamental and applied biological sciences. Psychology Genes Genetic aspects Humanities and Social Sciences Humans I-kappa B Kinase - metabolism Immunity - immunology Inflammation Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Interleukin-1beta - metabolism Lesions Mass spectrometry Mice Molecular and cellular biology multidisciplinary Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Mutation Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism NF-kappa B - metabolism Phenotype Physiological aspects Prevention Proteins Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Receptors, Tumor Necrosis Factor - deficiency Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Recruitment Science Science (multidisciplinary) Signal Transduction Skin - cytology Skin - immunology Skin - metabolism Skin - pathology Transcription Factors Tumor necrosis factor Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - genetics Ubiquitin - chemistry Ubiquitin - metabolism Ubiquitin-proteasome system Ubiquitin-Protein Ligase Complexes - chemistry Ubiquitin-Protein Ligase Complexes - metabolism Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitination
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