Epidermal Growth Factor Receptor-targeted I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene

We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of radioiodine in neuroblastoma tumors after systemic nonviral polyplex-mediated sodium iodide symporter (NIS) gene delivery. In the present study, we used novel polyplexes based on linear polyethylenimine (LPEI), polyet...

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Veröffentlicht in:	Molecular therapy 2011-04, Vol.19 (4), p.676-685
Hauptverfasser:	Klutz, Kathrin, Schaffert, David, Willhauck, Michael J, Grünwald, Geoffrey K, Haase, Rudolf, Wunderlich, Nathalie, Zach, Christian, Gildehaus, Franz J, Senekowitsch-Schmidtke, Reingard, Göke, Burkhard, Wagner, Ernst, Ogris, Manfred, Spitzweg, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Genetic Therapy - methods Humans Iodine Radioisotopes - therapeutic use Liver Neoplasms - radiotherapy Liver Neoplasms - therapy Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Polymerase Chain Reaction Polymers - administration & dosage Polymers - chemistry Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Symporters - genetics
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