Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

Objective Macrophage migration inhibitory factor (MIF) facilitates multiple aspects of inflammatory arthritis, the pathogenesis of which has been significantly linked to the activity of neutrophils. The effects of MIF on neutrophil recruitment are unknown. This study was undertaken to investigate th...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2011-04, Vol.63 (4), p.960-970
Hauptverfasser:	Santos, Leilani L., Fan, Huapeng, Hall, Pam, Ngo, Devi, Mackay, Charles R., Fingerle‐Rowson, Gunter, Bucala, Richard, Hickey, Michael J., Morand, Eric F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - physiology Animals Arthritis Arthritis, Experimental - pathology Arthritis, Experimental - physiopathology Biological and medical sciences Cell Movement - drug effects Chemokine CXCL1 - pharmacology Chemokines Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - physiology Disease Models, Animal Diseases of the osteoarticular system Extracellular Signal-Regulated MAP Kinases - metabolism Inflammatory joint diseases Macrophage Migration-Inhibitory Factors - deficiency Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - physiology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Migration Neutrophils - drug effects Neutrophils - pathology Recruitment Rodents
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