Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis

As renal lipotoxicity can lead to chronic kidney disease (CKD), we examined the role of peroxisome proliferator-activated receptor (PPAR)-α, a positive regulator of renal lipolysis. Feeding mice a high-fat diet induced glomerular injury, and treating them with fenofibrate, a PPARα agonist, increased...

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Veröffentlicht in:	Kidney international 2011-04, Vol.79 (8), p.871-882
Hauptverfasser:	Tanaka, Yuki, Kume, Shinji, Araki, Shin-ichi, Isshiki, Keiji, Chin-Kanasaki, Masami, Sakaguchi, Masayoshi, Sugimoto, Toshiro, Koya, Daisuke, Haneda, Masakazu, Kashiwagi, Atsunori, Maegawa, Hiroshi, Uzu, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Base Sequence Biological and medical sciences Cells, Cultured Chemokine CCL2 - metabolism chronic kidney disease Dietary Fats - administration & dosage Disease Models, Animal DNA Primers - genetics Fenofibrate - pharmacology Kidney - drug effects Kidney - metabolism Kidneys Lipolysis - drug effects Lipolysis - physiology lipolytic enzymes Male Medical sciences Mice Mice, Inbred C57BL Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Oxidative Stress - drug effects pathophysiology PPAR alpha - agonists PPAR alpha - metabolism Renal failure Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - metabolism renal lipotoxicity RNA, Messenger - genetics RNA, Messenger - metabolism Serpin E2 - genetics Serpin E2 - metabolism Serum Albumin, Bovine - administration & dosage Urinary system involvement in other diseases. Miscellaneous
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