Long‐Term Response of the Left Ventricle to Cardiac Resynchronization Therapy: Insights From Standard and Strain Echocardiography
Congest Heart Fail. 2011;17:70–78. ©2011 Wiley Periodicals, Inc. Left ventricular (LV) response to cardiac resynchronization therapy (CRT) has typically been studied over 3‐ to 12‐month periods. Longer‐term data are unclear and response of strain parameters has not been reported. The authors evaluat...
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| creator | Kalogeropoulos, Andreas Savoye, Louise P. Georgiopoulou, Vasiliki Raj, Leah Lloyd, Michael S. Chiladakis, John Lerakis, Stamatios Alexopoulos, Dimitrios Butler, Javed |
| description | Congest Heart Fail. 2011;17:70–78. ©2011 Wiley Periodicals, Inc.
Left ventricular (LV) response to cardiac resynchronization therapy (CRT) has typically been studied over 3‐ to 12‐month periods. Longer‐term data are unclear and response of strain parameters has not been reported. The authors evaluated long‐term response with standard and strain echocardiography in 57 patients (52±15 years; 40 male; 30 white; 15 with ischemic etiology) who received a CRT‐defibrillator between January 2004 and December 2005. Median ejection fraction (EF) at baseline was 22% (17%–25%). Global longitudinal, radial, and circumferential strain were −6.5% (−5.0% to −8.4%), 10.4% (6.9%–15.1%), and −7.6% (−5.5% to −10.8%), respectively. After a median of 42 months, EF increased by 5% (−1% to 15%; P |
| doi_str_mv | 10.1111/j.1751-7133.2011.00212.x |
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Left ventricular (LV) response to cardiac resynchronization therapy (CRT) has typically been studied over 3‐ to 12‐month periods. Longer‐term data are unclear and response of strain parameters has not been reported. The authors evaluated long‐term response with standard and strain echocardiography in 57 patients (52±15 years; 40 male; 30 white; 15 with ischemic etiology) who received a CRT‐defibrillator between January 2004 and December 2005. Median ejection fraction (EF) at baseline was 22% (17%–25%). Global longitudinal, radial, and circumferential strain were −6.5% (−5.0% to −8.4%), 10.4% (6.9%–15.1%), and −7.6% (−5.5% to −10.8%), respectively. After a median of 42 months, EF increased by 5% (−1% to 15%; P<.001), with improvements in circumferential (−3.2% [−5.2% to 1.5%]; P=.001), longitudinal (−0.5% [−3.4% to 1.2%]; P=.035), and radial (1.4% [−1.1% to 9.2%]; P=.035) strain. Changes in volumes were nonsignificant. EF improvement ≥5% was observed in 29 patients (50.9%). Relative improvement ≥15% in longitudinal, radial, and circumferential strain was observed in 26 (45.6%), 29 (50.9%), and 37 (64.9%) patients, respectively. Improvement in longitudinal strain and EF was strongly associated with lower rates of heart failure–related and all‐cause readmissions. A wide range of long‐term LV responses to CRT was observed, with approximately 50% of patients showing favorable responses.</description><identifier>ISSN: 1527-5299</identifier><identifier>EISSN: 1751-7133</identifier><identifier>DOI: 10.1111/j.1751-7133.2011.00212.x</identifier><identifier>PMID: 21449995</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Cardiac Resynchronization Therapy - methods ; Echocardiography - methods ; Female ; Follow-Up Studies ; Heart Failure - diagnostic imaging ; Heart Failure - physiopathology ; Heart Failure - therapy ; Heart Ventricles - diagnostic imaging ; Humans ; Male ; Middle Aged ; Treatment Outcome</subject><ispartof>Congestive heart failure (Greenwich, Conn.), 2011-03, Vol.17 (2), p.70-78</ispartof><rights>2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2832-526ee9561511dd24838d8ace01701367d5f529276233410ae7f18104f4ad8833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1751-7133.2011.00212.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1751-7133.2011.00212.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21449995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalogeropoulos, Andreas</creatorcontrib><creatorcontrib>Savoye, Louise P.</creatorcontrib><creatorcontrib>Georgiopoulou, Vasiliki</creatorcontrib><creatorcontrib>Raj, Leah</creatorcontrib><creatorcontrib>Lloyd, Michael S.</creatorcontrib><creatorcontrib>Chiladakis, John</creatorcontrib><creatorcontrib>Lerakis, Stamatios</creatorcontrib><creatorcontrib>Alexopoulos, Dimitrios</creatorcontrib><creatorcontrib>Butler, Javed</creatorcontrib><title>Long‐Term Response of the Left Ventricle to Cardiac Resynchronization Therapy: Insights From Standard and Strain Echocardiography</title><title>Congestive heart failure (Greenwich, Conn.)</title><addtitle>Congest Heart Fail</addtitle><description>Congest Heart Fail. 2011;17:70–78. ©2011 Wiley Periodicals, Inc.
Left ventricular (LV) response to cardiac resynchronization therapy (CRT) has typically been studied over 3‐ to 12‐month periods. Longer‐term data are unclear and response of strain parameters has not been reported. The authors evaluated long‐term response with standard and strain echocardiography in 57 patients (52±15 years; 40 male; 30 white; 15 with ischemic etiology) who received a CRT‐defibrillator between January 2004 and December 2005. Median ejection fraction (EF) at baseline was 22% (17%–25%). Global longitudinal, radial, and circumferential strain were −6.5% (−5.0% to −8.4%), 10.4% (6.9%–15.1%), and −7.6% (−5.5% to −10.8%), respectively. After a median of 42 months, EF increased by 5% (−1% to 15%; P<.001), with improvements in circumferential (−3.2% [−5.2% to 1.5%]; P=.001), longitudinal (−0.5% [−3.4% to 1.2%]; P=.035), and radial (1.4% [−1.1% to 9.2%]; P=.035) strain. Changes in volumes were nonsignificant. EF improvement ≥5% was observed in 29 patients (50.9%). Relative improvement ≥15% in longitudinal, radial, and circumferential strain was observed in 26 (45.6%), 29 (50.9%), and 37 (64.9%) patients, respectively. Improvement in longitudinal strain and EF was strongly associated with lower rates of heart failure–related and all‐cause readmissions. A wide range of long‐term LV responses to CRT was observed, with approximately 50% of patients showing favorable responses.</description><subject>Cardiac Resynchronization Therapy - methods</subject><subject>Echocardiography - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Treatment Outcome</subject><issn>1527-5299</issn><issn>1751-7133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kcFO3DAQQC1UBBT4BeRbT5t67HjjVL1UKxaQVqoEK66WSSYbrxJ7a2cF6akSP9Bv7JfgAMWXmdG8GWn8CKHAMkjv6zaDQsKsACEyzgAyxjjw7OmAnHw0PqVc8mImeVkek88xbhmTQqjyiBxzyPOyLOUJeV55t_n35-8aQ09vMe68i0h9Q4cW6Qqbgd6jG4KtOqSDpwsTamuqiRxd1Qbv7G8zWO_ousVgduM3euOi3bRDpMvge3o3GFenIZpCKoKxjl5Wra-mRX6TRtrxjBw2pot4_h5PyXp5uV5cz1Y_r24WP1aziivB0yFzxFLOQQLUNc-VULUyFTIoGIh5Ucsm3cqLORciB2awaEABy5vc1EoJcUq-vK3dBf9rj3HQvY0Vdp1x6PdRK1kWOWdSJfLindw_9FjrXbC9CaP-_20J-P4GPNoOx48-MD3p0Vs9WdCTBT3p0a969JNeXC9TIl4Aay6D9Q</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Kalogeropoulos, Andreas</creator><creator>Savoye, Louise P.</creator><creator>Georgiopoulou, Vasiliki</creator><creator>Raj, Leah</creator><creator>Lloyd, Michael S.</creator><creator>Chiladakis, John</creator><creator>Lerakis, Stamatios</creator><creator>Alexopoulos, Dimitrios</creator><creator>Butler, Javed</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Long‐Term Response of the Left Ventricle to Cardiac Resynchronization Therapy: Insights From Standard and Strain Echocardiography</title><author>Kalogeropoulos, Andreas ; Savoye, Louise P. ; Georgiopoulou, Vasiliki ; Raj, Leah ; Lloyd, Michael S. ; Chiladakis, John ; Lerakis, Stamatios ; Alexopoulos, Dimitrios ; Butler, Javed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2832-526ee9561511dd24838d8ace01701367d5f529276233410ae7f18104f4ad8833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Cardiac Resynchronization Therapy - methods</topic><topic>Echocardiography - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalogeropoulos, Andreas</creatorcontrib><creatorcontrib>Savoye, Louise P.</creatorcontrib><creatorcontrib>Georgiopoulou, Vasiliki</creatorcontrib><creatorcontrib>Raj, Leah</creatorcontrib><creatorcontrib>Lloyd, Michael S.</creatorcontrib><creatorcontrib>Chiladakis, John</creatorcontrib><creatorcontrib>Lerakis, Stamatios</creatorcontrib><creatorcontrib>Alexopoulos, Dimitrios</creatorcontrib><creatorcontrib>Butler, Javed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Congestive heart failure (Greenwich, Conn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalogeropoulos, Andreas</au><au>Savoye, Louise P.</au><au>Georgiopoulou, Vasiliki</au><au>Raj, Leah</au><au>Lloyd, Michael S.</au><au>Chiladakis, John</au><au>Lerakis, Stamatios</au><au>Alexopoulos, Dimitrios</au><au>Butler, Javed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐Term Response of the Left Ventricle to Cardiac Resynchronization Therapy: Insights From Standard and Strain Echocardiography</atitle><jtitle>Congestive heart failure (Greenwich, Conn.)</jtitle><addtitle>Congest Heart Fail</addtitle><date>2011-03</date><risdate>2011</risdate><volume>17</volume><issue>2</issue><spage>70</spage><epage>78</epage><pages>70-78</pages><issn>1527-5299</issn><eissn>1751-7133</eissn><abstract>Congest Heart Fail. 2011;17:70–78. ©2011 Wiley Periodicals, Inc.
Left ventricular (LV) response to cardiac resynchronization therapy (CRT) has typically been studied over 3‐ to 12‐month periods. Longer‐term data are unclear and response of strain parameters has not been reported. The authors evaluated long‐term response with standard and strain echocardiography in 57 patients (52±15 years; 40 male; 30 white; 15 with ischemic etiology) who received a CRT‐defibrillator between January 2004 and December 2005. Median ejection fraction (EF) at baseline was 22% (17%–25%). Global longitudinal, radial, and circumferential strain were −6.5% (−5.0% to −8.4%), 10.4% (6.9%–15.1%), and −7.6% (−5.5% to −10.8%), respectively. After a median of 42 months, EF increased by 5% (−1% to 15%; P<.001), with improvements in circumferential (−3.2% [−5.2% to 1.5%]; P=.001), longitudinal (−0.5% [−3.4% to 1.2%]; P=.035), and radial (1.4% [−1.1% to 9.2%]; P=.035) strain. Changes in volumes were nonsignificant. EF improvement ≥5% was observed in 29 patients (50.9%). Relative improvement ≥15% in longitudinal, radial, and circumferential strain was observed in 26 (45.6%), 29 (50.9%), and 37 (64.9%) patients, respectively. Improvement in longitudinal strain and EF was strongly associated with lower rates of heart failure–related and all‐cause readmissions. A wide range of long‐term LV responses to CRT was observed, with approximately 50% of patients showing favorable responses.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21449995</pmid><doi>10.1111/j.1751-7133.2011.00212.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiac Resynchronization Therapy - methods Echocardiography - methods Female Follow-Up Studies Heart Failure - diagnostic imaging Heart Failure - physiopathology Heart Failure - therapy Heart Ventricles - diagnostic imaging Humans Male Middle Aged Treatment Outcome |
| title | Long‐Term Response of the Left Ventricle to Cardiac Resynchronization Therapy: Insights From Standard and Strain Echocardiography |
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