Safe and Efficient Tetrazole Synthesis in a Continuous-Flow Microreactor
Safer flow: The synthesis of 5‐substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near‐equimolar amount of NaN3, yet nonetheless displays a broad substrate scope. The hazards associated with HN3 are essentially eliminated, shock‐sensitive...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2011-04, Vol.50 (15), p.3525-3528 |
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| container_end_page | 3528 |
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| container_issue | 15 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Palde, Prakash B. Jamison, Timothy F. |
| description | Safer flow: The synthesis of 5‐substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near‐equimolar amount of NaN3, yet nonetheless displays a broad substrate scope. The hazards associated with HN3 are essentially eliminated, shock‐sensitive metal azides such as Zn(N3)2 are avoided, and residual NaN3 is quenched in‐line with NaNO2. |
| doi_str_mv | 10.1002/anie.201006272 |
| format | Article |
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| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | azides Bioreactors continuous-flow synthesis Microchemistry microreactors synthetic methods tetrazoles Tetrazoles - chemical synthesis Tetrazoles - chemistry |
| title | Safe and Efficient Tetrazole Synthesis in a Continuous-Flow Microreactor |
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