Role of Chemistry versus Substrate Binding in Recruiting Promiscuous Enzyme Functions

Two different scenarios for the recruitment of evolutionary starting points and their subsequent divergence to give new enzymes have been described. The coincidental, promiscuous starting activity may regard the same reaction chemistry on a new substrate (substrate ambiguity). Alternatively, substra...

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Veröffentlicht in:	Biochemistry (Easton) 2011-04, Vol.50 (13), p.2683-2690
Hauptverfasser:	Khersonsky, Olga, Malitsky, Sergey, Rogachev, Ilana, Tawfik, Dan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Escherichia coli K12 - enzymology Escherichia coli K12 - genetics Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Evolution, Molecular Proteome - metabolism Substrate Specificity Xenobiotics - chemistry Xenobiotics - metabolism
Online-Zugang:	Volltext
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