Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats

Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties, which makes BNP an attractive agent for attenuating th...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2011-03, Vol.123 (12), p.1297-1305
Hauptverfasser:	CATALIOTTI, Alessandro, TONNE, Jason M, BURNETT, John C, IKEDA, Yasuhiro, BELLAVIA, Diego, MARTIN, Fernando L, OEHLER, Elise A, HARDERS, Gerald E, CAMPBELL, Jarryd M, PENG, Kaw-Whye, RUSSELL, Stephen J, MALATINO, Lorenzo S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Biological and medical sciences Blood and lymphatic vessels Blood Pressure - genetics Brain-Derived Neurotrophic Factor - genetics Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Echocardiography Genetic Therapy - methods Heart Failure - diagnostic imaging Heart Failure - genetics Heart Failure - prevention & control Hypertension - genetics Hypertension - therapy Medical sciences Plasmids - genetics Protein Precursors - genetics Rats Rats, Inbred SHR Rats, Wistar Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Ventricular Remodeling - genetics
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