Involvement of Rho-kinase in collar-induced vasoconstriction and vascular hypersensitivity to serotonin in rat carotid

Abstract Background Vasoconstriction and vascular hypersensitivity to serotonin has been described previously in animal models of adventitia injury. The present study was undertaken to investigate the contribution of the RhoA/Rho-kinase pathway to the collar-induced the change of vascular contractil...

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Veröffentlicht in:	International journal of cardiology 2011-04, Vol.148 (2), p.168-173
Hauptverfasser:	Xie, Lianna, Zeng, Dingyin, Zhang, Haishan, Sun, Danmeng, Pang, Xuefeng, Guan, Qigang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Adventitia Angiotensin II Angiotensin II type 1 receptor Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Biological and medical sciences Cardiology. Vascular system Cardiovascular Carotid Artery Diseases - drug therapy Carotid Artery Diseases - metabolism Carotid Artery Diseases - physiopathology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Disease Models, Animal Male Medical sciences Protein Kinase Inhibitors - pharmacology Rats Rats, Inbred WKY Receptor, Angiotensin, Type 1 - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Rho-kinase rhoA GTP-Binding Protein - metabolism Serotonin Serotonin - pharmacology Silicone collar Silicones Tetrazoles - pharmacology Valine - analogs & derivatives Valine - pharmacology Valsartan Vasoconstriction Vasoconstriction - drug effects Vasoconstriction - physiology
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