Synthesis and antiviral activity of N⁹-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N⁶-substituted adenines and 2,6-diaminopurines

An efficient method for the synthesis of N⁹-[3-fluoro-2-(phosphonomethoxy)propyl] (FPMP) derivatives of purine bases has been developed. Both (R)- and (S)-enantiomers of the N⁶-substituted FPMP derivatives of adenine and 2,6-diaminopurine were prepared and their anti-human immunodeficiency virus (HI...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2011-04, Vol.19 (7), p.2114-2124
Hauptverfasser:	Baszczyňski, Ondřej, Jansa, Petr, Dračínský, Martin, Klepetářová, Blanka, Holý, Antonín, Votruba, Ivan, Clercq, Erik de, Balzarini, Jan, Janeba, Zlatko
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - analogs & derivatives 2-Aminopurine - chemical synthesis 2-Aminopurine - chemistry 2-Aminopurine - pharmacology 3T3 Cells adenine Adenine - analogs & derivatives Adenine - chemical synthesis Adenine - chemistry Adenine - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents antiretroviral agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology antiviral properties Biological and medical sciences Cells, Cultured chemistry Crystallography, X-Ray Dose-Response Relationship, Drug HIV-1 - drug effects HIV-2 - drug effects Humans immunosuppression (physiological) Medical sciences Mice Mice, Inbred C3H Moloney murine sarcoma virus - drug effects Organophosphonates - chemical synthesis Organophosphonates - chemistry Organophosphonates - pharmacology Pharmacology. Drug treatments Purines - chemical synthesis Purines - chemistry Purines - pharmacology sarcoma Structure-Activity Relationship viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!